PTTG1

 

Full name: PTTG1 regulator of sister chromatid separation, securin Alias Symbol: PTTG|HPTTG|EAP1|securin
Type: protein-coding gene Cytoband: 5q33.3
Entrez ID: 9232 HGNC ID: HGNC:9690 Ensembl Gene: ENSG00000164611 OMIM ID: 604147
Drug and gene relationship at DGIdb
Screen Evidence:

 

PTTG1 involved pathways:

KEGG pathway Description View
hsa04110Cell cycle
hsa04114Oocyte meiosis
hsa05166HTLV-I infection

 

Expression of PTTG1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 PTTG1 9232 203554_x_at 0.6335 0.1717
GSE20347 PTTG1 9232 203554_x_at 0.5751 0.0060
GSE23400 PTTG1 9232 203554_x_at 0.8025 0.0000
GSE26886 PTTG1 9232 203554_x_at 0.6842 0.0003
GSE29001 PTTG1 9232 203554_x_at 0.5533 0.1462
GSE38129 PTTG1 9232 203554_x_at 1.1860 0.0000
GSE45670 PTTG1 9232 203554_x_at 0.7389 0.0007
GSE53622 PTTG1 9232 118962 0.6855 0.0000
GSE53624 PTTG1 9232 118962 1.1024 0.0000
GSE63941 PTTG1 9232 203554_x_at 2.9813 0.0004
GSE77861 PTTG1 9232 203554_x_at 0.4044 0.0627
GSE97050 PTTG1 9232 A_23_P7636 1.2573 0.1456
SRP007169 PTTG1 9232 RNAseq 0.9276 0.1209
SRP064894 PTTG1 9232 RNAseq 0.9940 0.0022
SRP133303 PTTG1 9232 RNAseq 1.0663 0.0007
SRP159526 PTTG1 9232 RNAseq 0.3928 0.1059
SRP193095 PTTG1 9232 RNAseq 0.0787 0.6965
SRP219564 PTTG1 9232 RNAseq 0.4965 0.5402
TCGA PTTG1 9232 RNAseq 1.2140 0.0000

Upregulated datasets: 5; Downregulated datasets: 0.  

 

Survival by PTTG1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of PTTG1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 PTTG1 9232 0 11 19
GSE20123 PTTG1 9232 0 11 19
GSE43470 PTTG1 9232 2 10 31
GSE46452 PTTG1 9232 0 27 32
GSE47630 PTTG1 9232 0 20 20
GSE54993 PTTG1 9232 9 2 59
GSE54994 PTTG1 9232 1 16 36
GSE60625 PTTG1 9232 0 0 11
GSE74703 PTTG1 9232 2 8 26
GSE74704 PTTG1 9232 0 6 14
TCGA PTTG1 9232 5 36 55

Total number of gains: 19; Total number of losses: 147; Total Number of normals: 322.  

 

Somatic mutations of PTTG1:

 

Generating mutation plots.

 

Highly correlated genes for PTTG1:

 

Showing top 20/1186 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
PTTG1HMMR0.75458913013
PTTG1RNASEH2A0.74926511011
PTTG1TPX20.74224212012
PTTG1CCNB20.73164113012
PTTG1KIF20A0.72732113012
PTTG1CENPF0.72687612012
PTTG1KIF4A0.72669311011
PTTG1FANCD20.724859505
PTTG1CENPK0.718221707
PTTG1AURKB0.71792213012
PTTG1UBE2T0.717397808
PTTG1CKS1B0.71670312012
PTTG1CDK10.7145412011
PTTG1PPP1R14C0.714088706
PTTG1NUF20.712312808
PTTG1TOP2A0.7076813011
PTTG1UBE2C0.70637813012
PTTG1MELK0.70245711010
PTTG1CCNB10.70172713010
PTTG1CDKN30.70149913012

For details and further investigation, click here