| Full name: complement factor H | Alias Symbol: HUS|FHL1|ARMS1|ARMD4 | ||
| Type: protein-coding gene | Cytoband: 1q31.3 | ||
| Entrez ID: 3075 | HGNC ID: HGNC:4883 | Ensembl Gene: ENSG00000000971 | OMIM ID: 134370 |
| Drug and gene relationship at DGIdb | |||
CFH involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa05150 | Staphylococcus aureus infection |
Expression of CFH:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CFH | 3075 | 213800_at | -1.0734 | 0.1918 | |
| GSE20347 | CFH | 3075 | 213800_at | -0.3040 | 0.4603 | |
| GSE23400 | CFH | 3075 | 213800_at | -0.5932 | 0.0003 | |
| GSE26886 | CFH | 3075 | 213800_at | -0.4132 | 0.5387 | |
| GSE29001 | CFH | 3075 | 213800_at | 0.6909 | 0.1485 | |
| GSE38129 | CFH | 3075 | 213800_at | -0.9145 | 0.0277 | |
| GSE45670 | CFH | 3075 | 213800_at | -1.8433 | 0.0002 | |
| GSE53622 | CFH | 3075 | 30289 | -0.9173 | 0.0000 | |
| GSE53624 | CFH | 3075 | 30289 | -0.9374 | 0.0000 | |
| GSE63941 | CFH | 3075 | 213800_at | -3.2423 | 0.1016 | |
| GSE77861 | CFH | 3075 | 213800_at | -0.1051 | 0.8236 | |
| GSE97050 | CFH | 3075 | A_33_P3318288 | 0.0138 | 0.9818 | |
| SRP007169 | CFH | 3075 | RNAseq | 1.3855 | 0.0064 | |
| SRP008496 | CFH | 3075 | RNAseq | 1.7754 | 0.0000 | |
| SRP064894 | CFH | 3075 | RNAseq | -0.3422 | 0.3414 | |
| SRP133303 | CFH | 3075 | RNAseq | -0.8468 | 0.0053 | |
| SRP159526 | CFH | 3075 | RNAseq | -0.5354 | 0.3020 | |
| SRP193095 | CFH | 3075 | RNAseq | 0.6124 | 0.0309 | |
| SRP219564 | CFH | 3075 | RNAseq | 0.5178 | 0.4611 | |
| TCGA | CFH | 3075 | RNAseq | -0.2331 | 0.0156 |
Upregulated datasets: 2; Downregulated datasets: 1.
Survival by CFH expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CFH:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CFH | 3075 | 6 | 1 | 23 | |
| GSE20123 | CFH | 3075 | 6 | 1 | 23 | |
| GSE43470 | CFH | 3075 | 5 | 1 | 37 | |
| GSE46452 | CFH | 3075 | 3 | 1 | 55 | |
| GSE47630 | CFH | 3075 | 14 | 0 | 26 | |
| GSE54993 | CFH | 3075 | 0 | 6 | 64 | |
| GSE54994 | CFH | 3075 | 16 | 0 | 37 | |
| GSE60625 | CFH | 3075 | 0 | 0 | 11 | |
| GSE74703 | CFH | 3075 | 5 | 1 | 30 | |
| GSE74704 | CFH | 3075 | 2 | 1 | 17 | |
| TCGA | CFH | 3075 | 41 | 6 | 49 |
Total number of gains: 98; Total number of losses: 18; Total Number of normals: 372.
Somatic mutations of CFH:
Generating mutation plots.
Highly correlated genes for CFH:
Showing top 20/757 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CFH | EBF1 | 0.719293 | 5 | 0 | 5 |
| CFH | CDC16 | 0.717751 | 3 | 0 | 3 |
| CFH | SPATS2L | 0.714788 | 3 | 0 | 3 |
| CFH | CILP | 0.706372 | 7 | 0 | 7 |
| CFH | FBLN1 | 0.702802 | 8 | 0 | 7 |
| CFH | SELP | 0.694977 | 5 | 0 | 5 |
| CFH | MACROD2 | 0.682704 | 3 | 0 | 3 |
| CFH | LYVE1 | 0.681169 | 7 | 0 | 7 |
| CFH | TNFSF12 | 0.680618 | 3 | 0 | 3 |
| CFH | CFHR2 | 0.678149 | 9 | 0 | 8 |
| CFH | CACNA2D4 | 0.677928 | 3 | 0 | 3 |
| CFH | TNFSF8 | 0.677379 | 4 | 0 | 3 |
| CFH | P2RY12 | 0.676522 | 5 | 0 | 5 |
| CFH | CLCC1 | 0.676158 | 3 | 0 | 3 |
| CFH | CTSO | 0.674109 | 11 | 0 | 11 |
| CFH | TK2 | 0.670937 | 4 | 0 | 3 |
| CFH | NMT2 | 0.669416 | 4 | 0 | 3 |
| CFH | EFEMP1 | 0.668337 | 8 | 0 | 7 |
| CFH | FAM193A | 0.661323 | 3 | 0 | 3 |
| CFH | GIMAP5 | 0.659458 | 4 | 0 | 3 |
For details and further investigation, click here
