| Full name: selenophosphate synthetase 2 | Alias Symbol: SPS2|SPS2b | ||
| Type: protein-coding gene | Cytoband: 16p11.2 | ||
| Entrez ID: 22928 | HGNC ID: HGNC:19686 | Ensembl Gene: ENSG00000179918 | OMIM ID: 606218 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of SEPHS2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SEPHS2 | 22928 | 200961_at | 0.4376 | 0.4265 | |
| GSE20347 | SEPHS2 | 22928 | 200961_at | 0.6173 | 0.0001 | |
| GSE23400 | SEPHS2 | 22928 | 200961_at | 0.5515 | 0.0000 | |
| GSE26886 | SEPHS2 | 22928 | 200961_at | 0.0631 | 0.7995 | |
| GSE29001 | SEPHS2 | 22928 | 200961_at | 0.7220 | 0.0196 | |
| GSE38129 | SEPHS2 | 22928 | 200961_at | 0.5445 | 0.0004 | |
| GSE45670 | SEPHS2 | 22928 | 200961_at | 0.5001 | 0.0033 | |
| GSE53622 | SEPHS2 | 22928 | 14001 | 0.5786 | 0.0000 | |
| GSE53624 | SEPHS2 | 22928 | 14001 | 0.7623 | 0.0000 | |
| GSE63941 | SEPHS2 | 22928 | 200961_at | -0.1138 | 0.8262 | |
| GSE77861 | SEPHS2 | 22928 | 200961_at | 0.4142 | 0.1719 | |
| GSE97050 | SEPHS2 | 22928 | A_23_P146798 | 0.4732 | 0.1325 | |
| SRP007169 | SEPHS2 | 22928 | RNAseq | -0.0605 | 0.8691 | |
| SRP008496 | SEPHS2 | 22928 | RNAseq | 0.0883 | 0.6563 | |
| SRP064894 | SEPHS2 | 22928 | RNAseq | 0.4865 | 0.0025 | |
| SRP133303 | SEPHS2 | 22928 | RNAseq | 0.7941 | 0.0000 | |
| SRP159526 | SEPHS2 | 22928 | RNAseq | 1.1735 | 0.0001 | |
| SRP193095 | SEPHS2 | 22928 | RNAseq | -0.1601 | 0.5411 | |
| SRP219564 | SEPHS2 | 22928 | RNAseq | 0.3805 | 0.3375 | |
| TCGA | SEPHS2 | 22928 | RNAseq | -0.0485 | 0.3234 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by SEPHS2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SEPHS2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SEPHS2 | 22928 | 5 | 5 | 20 | |
| GSE20123 | SEPHS2 | 22928 | 5 | 4 | 21 | |
| GSE43470 | SEPHS2 | 22928 | 3 | 3 | 37 | |
| GSE46452 | SEPHS2 | 22928 | 38 | 1 | 20 | |
| GSE47630 | SEPHS2 | 22928 | 11 | 7 | 22 | |
| GSE54993 | SEPHS2 | 22928 | 2 | 5 | 63 | |
| GSE54994 | SEPHS2 | 22928 | 5 | 9 | 39 | |
| GSE60625 | SEPHS2 | 22928 | 4 | 0 | 7 | |
| GSE74703 | SEPHS2 | 22928 | 3 | 2 | 31 | |
| GSE74704 | SEPHS2 | 22928 | 3 | 2 | 15 | |
| TCGA | SEPHS2 | 22928 | 20 | 10 | 66 |
Total number of gains: 99; Total number of losses: 48; Total Number of normals: 341.
Somatic mutations of SEPHS2:
Generating mutation plots.
Highly correlated genes for SEPHS2:
Showing top 20/943 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SEPHS2 | DCTPP1 | 0.733547 | 10 | 0 | 10 |
| SEPHS2 | PDIA5 | 0.703663 | 3 | 0 | 3 |
| SEPHS2 | TXNDC12 | 0.690827 | 6 | 0 | 5 |
| SEPHS2 | SGMS1 | 0.686687 | 3 | 0 | 3 |
| SEPHS2 | TTYH3 | 0.682198 | 4 | 0 | 4 |
| SEPHS2 | UBE2I | 0.664591 | 9 | 0 | 8 |
| SEPHS2 | APOC1 | 0.663416 | 5 | 0 | 4 |
| SEPHS2 | NOMO1 | 0.661557 | 3 | 0 | 3 |
| SEPHS2 | ALG10 | 0.66099 | 5 | 0 | 5 |
| SEPHS2 | SNX10 | 0.657767 | 8 | 0 | 8 |
| SEPHS2 | RNASEH2A | 0.655221 | 10 | 0 | 9 |
| SEPHS2 | USP39 | 0.65408 | 9 | 0 | 9 |
| SEPHS2 | NAA50 | 0.653137 | 7 | 0 | 6 |
| SEPHS2 | FNDC1 | 0.647866 | 3 | 0 | 3 |
| SEPHS2 | LYPD6B | 0.647756 | 4 | 0 | 3 |
| SEPHS2 | KIF22 | 0.646227 | 10 | 0 | 8 |
| SEPHS2 | RFC4 | 0.645984 | 11 | 0 | 9 |
| SEPHS2 | FNDC3B | 0.644511 | 8 | 0 | 6 |
| SEPHS2 | NUP93 | 0.643321 | 10 | 0 | 8 |
| SEPHS2 | CKS1B | 0.643163 | 10 | 0 | 9 |
For details and further investigation, click here
