NFKB2

 

Full name: nuclear factor kappa B subunit 2 Alias Symbol: LYT-10|p52|p105|NF-kB2|p49/p100
Type: protein-coding gene Cytoband: 10q24.32
Entrez ID: 4791 HGNC ID: HGNC:7795 Ensembl Gene: ENSG00000077150 OMIM ID: 164012
Drug and gene relationship at DGIdb

 

NFKB2 involved pathways:

KEGG pathway Description View
hsa04010MAPK signaling pathway
hsa04064NF-kappa B signaling pathway
hsa04380Osteoclast differentiation
hsa05166HTLV-I infection
hsa05169Epstein-Barr virus infection
hsa05200Pathways in cancer

 

Expression of NFKB2:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 NFKB2 4791 207535_s_at 0.5388 0.0739
GSE20347 NFKB2 4791 207535_s_at 0.1606 0.1061
GSE23400 NFKB2 4791 207535_s_at 0.1384 0.0243
GSE26886 NFKB2 4791 209636_at 0.4348 0.0086
GSE29001 NFKB2 4791 207535_s_at 0.3910 0.2196
GSE38129 NFKB2 4791 207535_s_at 0.1410 0.3176
GSE45670 NFKB2 4791 207535_s_at -0.1200 0.4433
GSE53622 NFKB2 4791 136168 0.7406 0.0000
GSE53624 NFKB2 4791 136168 0.6674 0.0000
GSE63941 NFKB2 4791 207535_s_at 0.9885 0.0042
GSE77861 NFKB2 4791 207535_s_at 0.1839 0.2943
GSE97050 NFKB2 4791 A_23_P202156 0.5675 0.1156
SRP007169 NFKB2 4791 RNAseq 0.6552 0.1827
SRP008496 NFKB2 4791 RNAseq 0.4494 0.1812
SRP064894 NFKB2 4791 RNAseq 0.5546 0.0097
SRP133303 NFKB2 4791 RNAseq 0.5439 0.0030
SRP159526 NFKB2 4791 RNAseq 0.6806 0.1241
SRP193095 NFKB2 4791 RNAseq 1.1480 0.0000
SRP219564 NFKB2 4791 RNAseq 0.5759 0.1240
TCGA NFKB2 4791 RNAseq 0.1458 0.0261

Upregulated datasets: 1; Downregulated datasets: 0.  

 

Survival by NFKB2 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of NFKB2:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 NFKB2 4791 2 9 19
GSE20123 NFKB2 4791 2 8 20
GSE43470 NFKB2 4791 0 8 35
GSE46452 NFKB2 4791 0 11 48
GSE47630 NFKB2 4791 2 14 24
GSE54993 NFKB2 4791 8 0 62
GSE54994 NFKB2 4791 1 11 41
GSE60625 NFKB2 4791 0 0 11
GSE74703 NFKB2 4791 0 5 31
GSE74704 NFKB2 4791 1 4 15
TCGA NFKB2 4791 6 28 62

Total number of gains: 22; Total number of losses: 98; Total Number of normals: 368.  

 

Somatic mutations of NFKB2:

 

Generating mutation plots.

 

Highly correlated genes for NFKB2:

 

Showing top 20/809 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
NFKB2FZD60.775715303
NFKB2ADAM170.768312303
NFKB2TMEM690.739821303
NFKB2NIPA20.737523303
NFKB2CCDC1270.735827303
NFKB2SLC46A10.72523303
NFKB2MRPL360.723936505
NFKB2FAU0.722346303
NFKB2GART0.718182303
NFKB2MRPS300.717015403
NFKB2MPV170.715712403
NFKB2SORL10.714964303
NFKB2SFXN40.714053303
NFKB2MRPS50.713989303
NFKB2ROMO10.711527303
NFKB2SIK10.709321303
NFKB2NDUFS60.707658403
NFKB2MTRR0.705701404
NFKB2XPNPEP10.704052303
NFKB2BCORL10.702812303

For details and further investigation, click here