| Full name: polo like kinase 2 | Alias Symbol: SNK | ||
| Type: protein-coding gene | Cytoband: 5q11.2 | ||
| Entrez ID: 10769 | HGNC ID: HGNC:19699 | Ensembl Gene: ENSG00000145632 | OMIM ID: 607023 |
| Related drugs: BI-2536, NMS-1286937... [more] | |||
PLK2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04068 | FoxO signaling pathway |
Expression of PLK2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PLK2 | 10769 | 201939_at | -0.8811 | 0.5251 | |
| GSE20347 | PLK2 | 10769 | 201939_at | -0.8280 | 0.0099 | |
| GSE23400 | PLK2 | 10769 | 201939_at | -0.0077 | 0.9668 | |
| GSE26886 | PLK2 | 10769 | 201939_at | -1.2870 | 0.0012 | |
| GSE29001 | PLK2 | 10769 | 201939_at | -0.7654 | 0.0659 | |
| GSE38129 | PLK2 | 10769 | 201939_at | -0.3149 | 0.3128 | |
| GSE45670 | PLK2 | 10769 | 201939_at | 0.1064 | 0.7706 | |
| GSE53622 | PLK2 | 10769 | 35197 | -0.1690 | 0.2998 | |
| GSE53624 | PLK2 | 10769 | 35197 | -0.2900 | 0.0025 | |
| GSE63941 | PLK2 | 10769 | 201939_at | -0.8552 | 0.5158 | |
| GSE77861 | PLK2 | 10769 | 201939_at | -0.5187 | 0.2904 | |
| GSE97050 | PLK2 | 10769 | A_23_P30254 | 0.6513 | 0.2057 | |
| SRP007169 | PLK2 | 10769 | RNAseq | -1.5125 | 0.0008 | |
| SRP008496 | PLK2 | 10769 | RNAseq | -1.5258 | 0.0000 | |
| SRP064894 | PLK2 | 10769 | RNAseq | -0.4373 | 0.0545 | |
| SRP133303 | PLK2 | 10769 | RNAseq | -0.1358 | 0.6294 | |
| SRP159526 | PLK2 | 10769 | RNAseq | 0.0468 | 0.9128 | |
| SRP193095 | PLK2 | 10769 | RNAseq | -0.4528 | 0.1082 | |
| SRP219564 | PLK2 | 10769 | RNAseq | -0.6209 | 0.2922 | |
| TCGA | PLK2 | 10769 | RNAseq | 0.3657 | 0.0007 |
Upregulated datasets: 0; Downregulated datasets: 3.
Survival by PLK2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PLK2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PLK2 | 10769 | 0 | 13 | 17 | |
| GSE20123 | PLK2 | 10769 | 0 | 13 | 17 | |
| GSE43470 | PLK2 | 10769 | 1 | 12 | 30 | |
| GSE46452 | PLK2 | 10769 | 0 | 28 | 31 | |
| GSE47630 | PLK2 | 10769 | 2 | 16 | 22 | |
| GSE54993 | PLK2 | 10769 | 8 | 1 | 61 | |
| GSE54994 | PLK2 | 10769 | 2 | 19 | 32 | |
| GSE60625 | PLK2 | 10769 | 0 | 0 | 11 | |
| GSE74703 | PLK2 | 10769 | 1 | 9 | 26 | |
| GSE74704 | PLK2 | 10769 | 0 | 6 | 14 | |
| TCGA | PLK2 | 10769 | 7 | 46 | 43 |
Total number of gains: 21; Total number of losses: 163; Total Number of normals: 304.
Somatic mutations of PLK2:
Generating mutation plots.
Highly correlated genes for PLK2:
Showing top 20/400 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PLK2 | BDP1 | 0.734081 | 3 | 0 | 3 |
| PLK2 | SNX14 | 0.726468 | 3 | 0 | 3 |
| PLK2 | CHMP1B | 0.7252 | 3 | 0 | 3 |
| PLK2 | TGFB2 | 0.72486 | 3 | 0 | 3 |
| PLK2 | SBF2 | 0.709316 | 3 | 0 | 3 |
| PLK2 | GABPA | 0.706154 | 3 | 0 | 3 |
| PLK2 | PHYHIPL | 0.695734 | 3 | 0 | 3 |
| PLK2 | THAP2 | 0.693958 | 3 | 0 | 3 |
| PLK2 | S100A13 | 0.677811 | 4 | 0 | 3 |
| PLK2 | SGPP1 | 0.674192 | 5 | 0 | 4 |
| PLK2 | VPS29 | 0.669083 | 3 | 0 | 3 |
| PLK2 | STYX | 0.667528 | 3 | 0 | 3 |
| PLK2 | ENKUR | 0.664286 | 3 | 0 | 3 |
| PLK2 | SAMD8 | 0.662979 | 3 | 0 | 3 |
| PLK2 | COG5 | 0.659536 | 3 | 0 | 3 |
| PLK2 | RTN3 | 0.658013 | 4 | 0 | 3 |
| PLK2 | SKAP2 | 0.656845 | 4 | 0 | 3 |
| PLK2 | FRMD6 | 0.650042 | 4 | 0 | 3 |
| PLK2 | PDHB | 0.649244 | 5 | 0 | 5 |
| PLK2 | CCDC126 | 0.648995 | 3 | 0 | 3 |
For details and further investigation, click here
