| Full name: SH2 domain containing 3A | Alias Symbol: NSP1 | ||
| Type: protein-coding gene | Cytoband: 19p13.3 | ||
| Entrez ID: 10045 | HGNC ID: HGNC:16885 | Ensembl Gene: ENSG00000125731 | OMIM ID: 604721 |
| Drug and gene relationship at DGIdb | |||
Expression of SH2D3A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SH2D3A | 10045 | 219513_s_at | -0.1024 | 0.9274 | |
| GSE20347 | SH2D3A | 10045 | 219513_s_at | -0.6045 | 0.0012 | |
| GSE23400 | SH2D3A | 10045 | 219513_s_at | -0.2261 | 0.0194 | |
| GSE26886 | SH2D3A | 10045 | 219513_s_at | -0.0331 | 0.9270 | |
| GSE29001 | SH2D3A | 10045 | 219513_s_at | -0.4717 | 0.1130 | |
| GSE38129 | SH2D3A | 10045 | 219513_s_at | -0.0395 | 0.8967 | |
| GSE45670 | SH2D3A | 10045 | 219513_s_at | 0.1453 | 0.5899 | |
| GSE53622 | SH2D3A | 10045 | 50091 | -0.1467 | 0.4635 | |
| GSE53624 | SH2D3A | 10045 | 50091 | -0.3556 | 0.0000 | |
| GSE63941 | SH2D3A | 10045 | 222169_x_at | 0.5295 | 0.0035 | |
| GSE77861 | SH2D3A | 10045 | 222169_x_at | 0.1436 | 0.5019 | |
| GSE97050 | SH2D3A | 10045 | A_33_P3254320 | 0.6127 | 0.4210 | |
| SRP007169 | SH2D3A | 10045 | RNAseq | -1.8974 | 0.0000 | |
| SRP008496 | SH2D3A | 10045 | RNAseq | -1.9456 | 0.0000 | |
| SRP064894 | SH2D3A | 10045 | RNAseq | -0.9237 | 0.0062 | |
| SRP133303 | SH2D3A | 10045 | RNAseq | -0.6425 | 0.0012 | |
| SRP159526 | SH2D3A | 10045 | RNAseq | -0.9945 | 0.0003 | |
| SRP193095 | SH2D3A | 10045 | RNAseq | -0.6388 | 0.0001 | |
| SRP219564 | SH2D3A | 10045 | RNAseq | -0.4747 | 0.5477 | |
| TCGA | SH2D3A | 10045 | RNAseq | 0.3255 | 0.0054 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by SH2D3A expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SH2D3A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SH2D3A | 10045 | 5 | 3 | 22 | |
| GSE20123 | SH2D3A | 10045 | 4 | 2 | 24 | |
| GSE43470 | SH2D3A | 10045 | 2 | 6 | 35 | |
| GSE46452 | SH2D3A | 10045 | 47 | 1 | 11 | |
| GSE47630 | SH2D3A | 10045 | 5 | 7 | 28 | |
| GSE54993 | SH2D3A | 10045 | 16 | 3 | 51 | |
| GSE54994 | SH2D3A | 10045 | 6 | 14 | 33 | |
| GSE60625 | SH2D3A | 10045 | 9 | 0 | 2 | |
| GSE74703 | SH2D3A | 10045 | 2 | 4 | 30 | |
| GSE74704 | SH2D3A | 10045 | 1 | 2 | 17 | |
| TCGA | SH2D3A | 10045 | 9 | 19 | 68 |
Total number of gains: 106; Total number of losses: 61; Total Number of normals: 321.
Somatic mutations of SH2D3A:
Generating mutation plots.
Highly correlated genes for SH2D3A:
Showing top 20/382 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SH2D3A | KIF21A | 0.784834 | 3 | 0 | 3 |
| SH2D3A | RAPGEFL1 | 0.752435 | 4 | 0 | 4 |
| SH2D3A | CHMP4C | 0.745845 | 5 | 0 | 4 |
| SH2D3A | TMEM30B | 0.712942 | 6 | 0 | 5 |
| SH2D3A | SLC7A5 | 0.711772 | 3 | 0 | 3 |
| SH2D3A | ARNTL2 | 0.710626 | 8 | 0 | 7 |
| SH2D3A | NIPAL1 | 0.704879 | 3 | 0 | 3 |
| SH2D3A | AP1S3 | 0.691414 | 5 | 0 | 4 |
| SH2D3A | ELOVL1 | 0.683608 | 4 | 0 | 3 |
| SH2D3A | GRHL2 | 0.6821 | 5 | 0 | 5 |
| SH2D3A | ZNF57 | 0.68193 | 4 | 0 | 4 |
| SH2D3A | ZNF808 | 0.675834 | 3 | 0 | 3 |
| SH2D3A | JAG1 | 0.669861 | 3 | 0 | 3 |
| SH2D3A | RNF6 | 0.668096 | 4 | 0 | 4 |
| SH2D3A | PTBP3 | 0.667992 | 8 | 0 | 6 |
| SH2D3A | EPS15 | 0.660553 | 3 | 0 | 3 |
| SH2D3A | CNKSR1 | 0.657855 | 10 | 0 | 8 |
| SH2D3A | SH3RF2 | 0.654426 | 4 | 0 | 4 |
| SH2D3A | NAT1 | 0.654188 | 3 | 0 | 3 |
| SH2D3A | LPCAT2 | 0.651739 | 3 | 0 | 3 |
For details and further investigation, click here
