| Full name: cholinergic receptor nicotinic alpha 1 subunit | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 2q31.1 | ||
| Entrez ID: 1134 | HGNC ID: HGNC:1955 | Ensembl Gene: ENSG00000138435 | OMIM ID: 100690 |
| Related drugs: ATRACURIUM, ATRACURIUM BESYLATE, CISATRACURIUM BESYLATE, DECAMETHONIUM BROMIDE, DOXACURIUM CHLORIDE, GALLAMINE, GALLAMINE TRIETHIODIDE, LOXAPINE, LYSERGIDE, METOCURINE IODIDE... [more] | |||
Expression of CHRNA1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CHRNA1 | 1134 | 206633_at | 0.3830 | 0.1070 | |
| GSE20347 | CHRNA1 | 1134 | 211039_at | 0.1335 | 0.1247 | |
| GSE23400 | CHRNA1 | 1134 | 206633_at | -0.0596 | 0.1410 | |
| GSE26886 | CHRNA1 | 1134 | 211039_at | 0.0001 | 0.9994 | |
| GSE29001 | CHRNA1 | 1134 | 206633_at | -0.1272 | 0.4202 | |
| GSE38129 | CHRNA1 | 1134 | 206633_at | 0.0627 | 0.4482 | |
| GSE45670 | CHRNA1 | 1134 | 206633_at | 0.0472 | 0.7014 | |
| GSE53622 | CHRNA1 | 1134 | 40759 | 2.9228 | 0.0000 | |
| GSE53624 | CHRNA1 | 1134 | 40759 | 2.5877 | 0.0000 | |
| GSE63941 | CHRNA1 | 1134 | 206633_at | -0.0046 | 0.9815 | |
| GSE77861 | CHRNA1 | 1134 | 211039_at | -0.0433 | 0.6843 | |
| GSE97050 | CHRNA1 | 1134 | A_33_P3365305 | 0.6743 | 0.2445 | |
| TCGA | CHRNA1 | 1134 | RNAseq | 4.6514 | 0.0000 |
Upregulated datasets: 3; Downregulated datasets: 0.
Survival by CHRNA1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CHRNA1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CHRNA1 | 1134 | 9 | 0 | 21 | |
| GSE20123 | CHRNA1 | 1134 | 9 | 0 | 21 | |
| GSE43470 | CHRNA1 | 1134 | 6 | 1 | 36 | |
| GSE46452 | CHRNA1 | 1134 | 1 | 4 | 54 | |
| GSE47630 | CHRNA1 | 1134 | 5 | 3 | 32 | |
| GSE54993 | CHRNA1 | 1134 | 0 | 5 | 65 | |
| GSE54994 | CHRNA1 | 1134 | 12 | 3 | 38 | |
| GSE60625 | CHRNA1 | 1134 | 0 | 3 | 8 | |
| GSE74703 | CHRNA1 | 1134 | 5 | 1 | 30 | |
| GSE74704 | CHRNA1 | 1134 | 5 | 0 | 15 | |
| TCGA | CHRNA1 | 1134 | 29 | 5 | 62 |
Total number of gains: 81; Total number of losses: 25; Total Number of normals: 382.
Somatic mutations of CHRNA1:
Generating mutation plots.
Highly correlated genes for CHRNA1:
Showing top 20/486 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CHRNA1 | KIF26B | 0.764458 | 4 | 0 | 4 |
| CHRNA1 | CDC25B | 0.761966 | 3 | 0 | 3 |
| CHRNA1 | MRGBP | 0.743345 | 3 | 0 | 3 |
| CHRNA1 | MMP12 | 0.742433 | 4 | 0 | 4 |
| CHRNA1 | LAMC2 | 0.732639 | 4 | 0 | 4 |
| CHRNA1 | DNMT3B | 0.725277 | 3 | 0 | 3 |
| CHRNA1 | MYBL2 | 0.724631 | 3 | 0 | 3 |
| CHRNA1 | COL5A1 | 0.715493 | 4 | 0 | 4 |
| CHRNA1 | KIF4A | 0.712794 | 3 | 0 | 3 |
| CHRNA1 | FCGR2A | 0.712525 | 3 | 0 | 3 |
| CHRNA1 | HOXD10 | 0.700731 | 3 | 0 | 3 |
| CHRNA1 | FMNL2 | 0.697119 | 4 | 0 | 4 |
| CHRNA1 | C1QTNF6 | 0.696907 | 4 | 0 | 3 |
| CHRNA1 | TRPM3 | 0.696261 | 3 | 0 | 3 |
| CHRNA1 | LPCAT1 | 0.696246 | 4 | 0 | 4 |
| CHRNA1 | PTK7 | 0.693771 | 4 | 0 | 3 |
| CHRNA1 | FADS3 | 0.690211 | 3 | 0 | 3 |
| CHRNA1 | UBE2T | 0.689736 | 3 | 0 | 3 |
| CHRNA1 | XPR1 | 0.688669 | 4 | 0 | 4 |
| CHRNA1 | CMC2 | 0.68846 | 3 | 0 | 3 |
For details and further investigation, click here
