PTK7

 

Full name: protein tyrosine kinase 7 (inactive) Alias Symbol: CCK4
Type: protein-coding gene Cytoband: 6p21.1
Entrez ID: 5754 HGNC ID: HGNC:9618 Ensembl Gene: ENSG00000112655 OMIM ID: 601890
Drug and gene relationship at DGIdb

 

Expression of PTK7:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 PTK7 5754 207011_s_at 1.7990 0.0057
GSE20347 PTK7 5754 207011_s_at 0.6196 0.0001
GSE23400 PTK7 5754 207011_s_at 1.0442 0.0000
GSE26886 PTK7 5754 207011_s_at 0.6710 0.0000
GSE29001 PTK7 5754 207011_s_at 0.6822 0.0085
GSE38129 PTK7 5754 207011_s_at 1.1181 0.0000
GSE45670 PTK7 5754 207011_s_at 1.2564 0.0001
GSE53622 PTK7 5754 80041 1.8940 0.0000
GSE53624 PTK7 5754 80041 1.8992 0.0000
GSE63941 PTK7 5754 207011_s_at -0.4930 0.3668
GSE77861 PTK7 5754 207011_s_at 0.5860 0.0765
GSE97050 PTK7 5754 A_24_P320545 1.0194 0.1404
SRP007169 PTK7 5754 RNAseq 1.4459 0.0000
SRP008496 PTK7 5754 RNAseq 1.8330 0.0000
SRP064894 PTK7 5754 RNAseq 2.0678 0.0000
SRP133303 PTK7 5754 RNAseq 1.8203 0.0000
SRP159526 PTK7 5754 RNAseq 1.4140 0.0000
SRP193095 PTK7 5754 RNAseq 1.7549 0.0000
SRP219564 PTK7 5754 RNAseq 1.4835 0.0033
TCGA PTK7 5754 RNAseq 0.6224 0.0000

Upregulated datasets: 13; Downregulated datasets: 0.  


 

Survival by PTK7 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  


Copy number change of PTK7:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 PTK7 5754 7 0 23
GSE20123 PTK7 5754 7 0 23
GSE43470 PTK7 5754 6 0 37
GSE46452 PTK7 5754 2 9 48
GSE47630 PTK7 5754 8 4 28
GSE54993 PTK7 5754 3 2 65
GSE54994 PTK7 5754 11 4 38
GSE60625 PTK7 5754 0 1 10
GSE74703 PTK7 5754 6 0 30
GSE74704 PTK7 5754 3 0 17
TCGA PTK7 5754 21 13 62

Total number of gains: 74; Total number of losses: 33; Total Number of normals: 381.  


 

Somatic mutations of PTK7:

 

Generating mutation plots.

 

Highly correlated genes for PTK7:

 

Showing top 20/2006 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
PTK7LAMB30.79312611011
PTK7ITGB40.78335211011
PTK7UBE2C0.7820411011
PTK7AGRN0.78054311011
PTK7DCAF130.775076606
PTK7SALL40.774615606
PTK7PLAU0.77339412011
PTK7XPR10.773342707
PTK7RTKN0.771705707
PTK7FSCN10.771411010
PTK7TTYH30.77036807
PTK7GMNN0.766772909
PTK7DCBLD10.765719707
PTK7WDR660.764375707
PTK7C1QTNF60.762567505
PTK7ATAD20.76191909
PTK7DNAJB110.761879505
PTK7COL27A10.761089606
PTK7MFAP20.76072813011
PTK7COL7A10.75713811011

For details and further investigation, click here