| Full name: protein tyrosine kinase 7 (inactive) | Alias Symbol: CCK4 | ||
| Type: protein-coding gene | Cytoband: 6p21.1 | ||
| Entrez ID: 5754 | HGNC ID: HGNC:9618 | Ensembl Gene: ENSG00000112655 | OMIM ID: 601890 |
| Drug and gene relationship at DGIdb | |||
Expression of PTK7:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PTK7 | 5754 | 207011_s_at | 1.7990 | 0.0057 | |
| GSE20347 | PTK7 | 5754 | 207011_s_at | 0.6196 | 0.0001 | |
| GSE23400 | PTK7 | 5754 | 207011_s_at | 1.0442 | 0.0000 | |
| GSE26886 | PTK7 | 5754 | 207011_s_at | 0.6710 | 0.0000 | |
| GSE29001 | PTK7 | 5754 | 207011_s_at | 0.6822 | 0.0085 | |
| GSE38129 | PTK7 | 5754 | 207011_s_at | 1.1181 | 0.0000 | |
| GSE45670 | PTK7 | 5754 | 207011_s_at | 1.2564 | 0.0001 | |
| GSE53622 | PTK7 | 5754 | 80041 | 1.8940 | 0.0000 | |
| GSE53624 | PTK7 | 5754 | 80041 | 1.8992 | 0.0000 | |
| GSE63941 | PTK7 | 5754 | 207011_s_at | -0.4930 | 0.3668 | |
| GSE77861 | PTK7 | 5754 | 207011_s_at | 0.5860 | 0.0765 | |
| GSE97050 | PTK7 | 5754 | A_24_P320545 | 1.0194 | 0.1404 | |
| SRP007169 | PTK7 | 5754 | RNAseq | 1.4459 | 0.0000 | |
| SRP008496 | PTK7 | 5754 | RNAseq | 1.8330 | 0.0000 | |
| SRP064894 | PTK7 | 5754 | RNAseq | 2.0678 | 0.0000 | |
| SRP133303 | PTK7 | 5754 | RNAseq | 1.8203 | 0.0000 | |
| SRP159526 | PTK7 | 5754 | RNAseq | 1.4140 | 0.0000 | |
| SRP193095 | PTK7 | 5754 | RNAseq | 1.7549 | 0.0000 | |
| SRP219564 | PTK7 | 5754 | RNAseq | 1.4835 | 0.0033 | |
| TCGA | PTK7 | 5754 | RNAseq | 0.6224 | 0.0000 |
Upregulated datasets: 13; Downregulated datasets: 0.
Survival by PTK7 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PTK7:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PTK7 | 5754 | 7 | 0 | 23 | |
| GSE20123 | PTK7 | 5754 | 7 | 0 | 23 | |
| GSE43470 | PTK7 | 5754 | 6 | 0 | 37 | |
| GSE46452 | PTK7 | 5754 | 2 | 9 | 48 | |
| GSE47630 | PTK7 | 5754 | 8 | 4 | 28 | |
| GSE54993 | PTK7 | 5754 | 3 | 2 | 65 | |
| GSE54994 | PTK7 | 5754 | 11 | 4 | 38 | |
| GSE60625 | PTK7 | 5754 | 0 | 1 | 10 | |
| GSE74703 | PTK7 | 5754 | 6 | 0 | 30 | |
| GSE74704 | PTK7 | 5754 | 3 | 0 | 17 | |
| TCGA | PTK7 | 5754 | 21 | 13 | 62 |
Total number of gains: 74; Total number of losses: 33; Total Number of normals: 381.
Somatic mutations of PTK7:
Generating mutation plots.
Highly correlated genes for PTK7:
Showing top 20/2006 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PTK7 | LAMB3 | 0.793126 | 11 | 0 | 11 |
| PTK7 | ITGB4 | 0.783352 | 11 | 0 | 11 |
| PTK7 | UBE2C | 0.78204 | 11 | 0 | 11 |
| PTK7 | AGRN | 0.780543 | 11 | 0 | 11 |
| PTK7 | DCAF13 | 0.775076 | 6 | 0 | 6 |
| PTK7 | SALL4 | 0.774615 | 6 | 0 | 6 |
| PTK7 | PLAU | 0.773394 | 12 | 0 | 11 |
| PTK7 | XPR1 | 0.773342 | 7 | 0 | 7 |
| PTK7 | RTKN | 0.771705 | 7 | 0 | 7 |
| PTK7 | FSCN1 | 0.7714 | 11 | 0 | 10 |
| PTK7 | TTYH3 | 0.77036 | 8 | 0 | 7 |
| PTK7 | GMNN | 0.766772 | 9 | 0 | 9 |
| PTK7 | DCBLD1 | 0.765719 | 7 | 0 | 7 |
| PTK7 | WDR66 | 0.764375 | 7 | 0 | 7 |
| PTK7 | C1QTNF6 | 0.762567 | 5 | 0 | 5 |
| PTK7 | ATAD2 | 0.76191 | 9 | 0 | 9 |
| PTK7 | DNAJB11 | 0.761879 | 5 | 0 | 5 |
| PTK7 | COL27A1 | 0.761089 | 6 | 0 | 6 |
| PTK7 | MFAP2 | 0.760728 | 13 | 0 | 11 |
| PTK7 | COL7A1 | 0.757138 | 11 | 0 | 11 |
For details and further investigation, click here
