| Full name: fatty acid desaturase 3 | Alias Symbol: CYB5RP | ||
| Type: protein-coding gene | Cytoband: 11q12.2 | ||
| Entrez ID: 3995 | HGNC ID: HGNC:3576 | Ensembl Gene: ENSG00000221968 | OMIM ID: 606150 |
| Drug and gene relationship at DGIdb | |||
Expression of FADS3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | FADS3 | 3995 | 204257_at | 0.6301 | 0.2101 | |
| GSE20347 | FADS3 | 3995 | 204257_at | 1.0782 | 0.0001 | |
| GSE23400 | FADS3 | 3995 | 216080_s_at | 0.3570 | 0.0003 | |
| GSE26886 | FADS3 | 3995 | 204257_at | 1.4628 | 0.0000 | |
| GSE29001 | FADS3 | 3995 | 204257_at | 0.6161 | 0.0084 | |
| GSE38129 | FADS3 | 3995 | 204257_at | 0.6728 | 0.0041 | |
| GSE45670 | FADS3 | 3995 | 204257_at | 0.3153 | 0.2305 | |
| GSE53622 | FADS3 | 3995 | 45997 | 1.0786 | 0.0000 | |
| GSE53624 | FADS3 | 3995 | 45997 | 1.3275 | 0.0000 | |
| GSE63941 | FADS3 | 3995 | 204257_at | 0.0572 | 0.9296 | |
| GSE77861 | FADS3 | 3995 | 204257_at | 0.5010 | 0.0258 | |
| GSE97050 | FADS3 | 3995 | A_23_P64404 | 0.4886 | 0.2144 | |
| SRP007169 | FADS3 | 3995 | RNAseq | 2.3083 | 0.0001 | |
| SRP008496 | FADS3 | 3995 | RNAseq | 2.6012 | 0.0000 | |
| SRP064894 | FADS3 | 3995 | RNAseq | 1.1778 | 0.0000 | |
| SRP133303 | FADS3 | 3995 | RNAseq | 1.1184 | 0.0007 | |
| SRP159526 | FADS3 | 3995 | RNAseq | 0.7123 | 0.0661 | |
| SRP193095 | FADS3 | 3995 | RNAseq | 2.9198 | 0.0000 | |
| SRP219564 | FADS3 | 3995 | RNAseq | 1.0946 | 0.0610 | |
| TCGA | FADS3 | 3995 | RNAseq | 0.2651 | 0.0220 |
Upregulated datasets: 9; Downregulated datasets: 0.
Survival by FADS3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of FADS3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | FADS3 | 3995 | 5 | 5 | 20 | |
| GSE20123 | FADS3 | 3995 | 5 | 5 | 20 | |
| GSE43470 | FADS3 | 3995 | 2 | 6 | 35 | |
| GSE46452 | FADS3 | 3995 | 8 | 4 | 47 | |
| GSE47630 | FADS3 | 3995 | 3 | 7 | 30 | |
| GSE54993 | FADS3 | 3995 | 3 | 0 | 67 | |
| GSE54994 | FADS3 | 3995 | 4 | 5 | 44 | |
| GSE60625 | FADS3 | 3995 | 0 | 3 | 8 | |
| GSE74703 | FADS3 | 3995 | 2 | 3 | 31 | |
| GSE74704 | FADS3 | 3995 | 4 | 3 | 13 | |
| TCGA | FADS3 | 3995 | 14 | 10 | 72 |
Total number of gains: 50; Total number of losses: 51; Total Number of normals: 387.
Somatic mutations of FADS3:
Generating mutation plots.
Highly correlated genes for FADS3:
Showing top 20/1276 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| FADS3 | SIPA1L3 | 0.768145 | 3 | 0 | 3 |
| FADS3 | TP53I13 | 0.747017 | 5 | 0 | 5 |
| FADS3 | CAPN12 | 0.741491 | 3 | 0 | 3 |
| FADS3 | P4HA2 | 0.735601 | 3 | 0 | 3 |
| FADS3 | FMNL2 | 0.733064 | 6 | 0 | 6 |
| FADS3 | GRAMD1A | 0.732551 | 5 | 0 | 5 |
| FADS3 | INHBA | 0.728821 | 11 | 0 | 11 |
| FADS3 | ALKBH6 | 0.720963 | 3 | 0 | 3 |
| FADS3 | SERPINH1 | 0.706613 | 11 | 0 | 11 |
| FADS3 | ENAH | 0.702202 | 10 | 0 | 10 |
| FADS3 | SH3PXD2B | 0.69966 | 6 | 0 | 5 |
| FADS3 | GTDC1 | 0.699239 | 4 | 0 | 4 |
| FADS3 | MSTO1 | 0.698329 | 4 | 0 | 4 |
| FADS3 | KDM6B | 0.696917 | 4 | 0 | 4 |
| FADS3 | FADS2 | 0.696849 | 8 | 0 | 8 |
| FADS3 | SF3A2 | 0.696398 | 4 | 0 | 4 |
| FADS3 | LOXL2 | 0.693384 | 11 | 0 | 10 |
| FADS3 | CHRNA1 | 0.690211 | 3 | 0 | 3 |
| FADS3 | TTYH3 | 0.687265 | 7 | 0 | 6 |
| FADS3 | COL12A1 | 0.68632 | 5 | 0 | 5 |
For details and further investigation, click here
