| Full name: FLII actin remodeling protein | Alias Symbol: FLI|FLIL|Fli1|MGC39265 | ||
| Type: protein-coding gene | Cytoband: 17p11.2 | ||
| Entrez ID: 2314 | HGNC ID: HGNC:3750 | Ensembl Gene: ENSG00000177731 | OMIM ID: 600362 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of FLII:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | FLII | 2314 | 212024_x_at | -0.2433 | 0.2006 | |
| GSE20347 | FLII | 2314 | 212024_x_at | -0.6618 | 0.0000 | |
| GSE23400 | FLII | 2314 | 212024_x_at | -0.3164 | 0.0000 | |
| GSE26886 | FLII | 2314 | 212024_x_at | -0.0927 | 0.5384 | |
| GSE29001 | FLII | 2314 | 212024_x_at | -0.7887 | 0.0020 | |
| GSE38129 | FLII | 2314 | 212024_x_at | -0.5511 | 0.0000 | |
| GSE45670 | FLII | 2314 | 212024_x_at | -0.4295 | 0.0007 | |
| GSE53622 | FLII | 2314 | 6519 | -0.6588 | 0.0000 | |
| GSE53624 | FLII | 2314 | 6519 | -0.8037 | 0.0000 | |
| GSE63941 | FLII | 2314 | 212024_x_at | -0.0635 | 0.9378 | |
| GSE77861 | FLII | 2314 | 212024_x_at | -0.2338 | 0.3282 | |
| GSE97050 | FLII | 2314 | A_23_P4425 | -0.4397 | 0.1764 | |
| SRP007169 | FLII | 2314 | RNAseq | -0.9548 | 0.0113 | |
| SRP008496 | FLII | 2314 | RNAseq | -0.7532 | 0.0016 | |
| SRP064894 | FLII | 2314 | RNAseq | 0.0438 | 0.8569 | |
| SRP133303 | FLII | 2314 | RNAseq | -0.4558 | 0.0026 | |
| SRP159526 | FLII | 2314 | RNAseq | -0.4650 | 0.0106 | |
| SRP193095 | FLII | 2314 | RNAseq | -0.4504 | 0.0000 | |
| SRP219564 | FLII | 2314 | RNAseq | -0.1471 | 0.6585 | |
| TCGA | FLII | 2314 | RNAseq | -0.0537 | 0.2099 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by FLII expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of FLII:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | FLII | 2314 | 3 | 3 | 24 | |
| GSE20123 | FLII | 2314 | 3 | 4 | 23 | |
| GSE43470 | FLII | 2314 | 1 | 5 | 37 | |
| GSE46452 | FLII | 2314 | 34 | 1 | 24 | |
| GSE47630 | FLII | 2314 | 7 | 1 | 32 | |
| GSE54993 | FLII | 2314 | 3 | 3 | 64 | |
| GSE54994 | FLII | 2314 | 6 | 6 | 41 | |
| GSE60625 | FLII | 2314 | 4 | 0 | 7 | |
| GSE74703 | FLII | 2314 | 1 | 2 | 33 | |
| GSE74704 | FLII | 2314 | 2 | 1 | 17 | |
| TCGA | FLII | 2314 | 19 | 23 | 54 |
Total number of gains: 83; Total number of losses: 49; Total Number of normals: 356.
Somatic mutations of FLII:
Generating mutation plots.
Highly correlated genes for FLII:
Showing top 20/1252 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| FLII | GMPPB | 0.735018 | 3 | 0 | 3 |
| FLII | ACADVL | 0.7318 | 9 | 0 | 9 |
| FLII | MIEF2 | 0.727318 | 5 | 0 | 5 |
| FLII | UBE2F | 0.723851 | 3 | 0 | 3 |
| FLII | NLRX1 | 0.719996 | 8 | 0 | 8 |
| FLII | CCDC159 | 0.714333 | 3 | 0 | 3 |
| FLII | FCHO2 | 0.71363 | 5 | 0 | 5 |
| FLII | NSRP1 | 0.712771 | 3 | 0 | 3 |
| FLII | GH2 | 0.71102 | 3 | 0 | 3 |
| FLII | NAGK | 0.710677 | 9 | 0 | 9 |
| FLII | ANO10 | 0.70868 | 10 | 0 | 10 |
| FLII | SGPL1 | 0.705918 | 3 | 0 | 3 |
| FLII | SH3GLB1 | 0.70421 | 9 | 0 | 9 |
| FLII | ABHD14B | 0.703999 | 4 | 0 | 3 |
| FLII | TRIM6 | 0.703598 | 5 | 0 | 4 |
| FLII | RRAD | 0.70246 | 8 | 0 | 7 |
| FLII | CTTNBP2NL | 0.700228 | 5 | 0 | 5 |
| FLII | PINK1 | 0.698753 | 9 | 0 | 7 |
| FLII | C12orf29 | 0.692775 | 7 | 0 | 6 |
| FLII | DHRS1 | 0.690579 | 8 | 0 | 7 |
For details and further investigation, click here
