| Full name: G protein subunit alpha L | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 18p11.21 | ||
| Entrez ID: 2774 | HGNC ID: HGNC:4388 | Ensembl Gene: ENSG00000141404 | OMIM ID: 139312 |
| Drug and gene relationship at DGIdb | |||
GNAL involved pathways:
Expression of GNAL:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GNAL | 2774 | 213924_at | -0.0227 | 0.9906 | |
| GSE20347 | GNAL | 2774 | 213924_at | -0.2581 | 0.3534 | |
| GSE23400 | GNAL | 2774 | 213924_at | -0.0600 | 0.4970 | |
| GSE26886 | GNAL | 2774 | 213924_at | -0.1248 | 0.8162 | |
| GSE29001 | GNAL | 2774 | 213924_at | -0.5048 | 0.3641 | |
| GSE38129 | GNAL | 2774 | 213924_at | -0.5272 | 0.1158 | |
| GSE45670 | GNAL | 2774 | 213924_at | -0.3964 | 0.4149 | |
| GSE53622 | GNAL | 2774 | 153737 | -0.9676 | 0.0000 | |
| GSE53624 | GNAL | 2774 | 153737 | -0.8695 | 0.0000 | |
| GSE63941 | GNAL | 2774 | 213924_at | -0.5141 | 0.5825 | |
| GSE77861 | GNAL | 2774 | 213924_at | 0.4472 | 0.1868 | |
| GSE97050 | GNAL | 2774 | A_33_P3337415 | -0.1567 | 0.4551 | |
| SRP007169 | GNAL | 2774 | RNAseq | 0.1565 | 0.7836 | |
| SRP008496 | GNAL | 2774 | RNAseq | 0.5498 | 0.1694 | |
| SRP064894 | GNAL | 2774 | RNAseq | 0.4914 | 0.0578 | |
| SRP133303 | GNAL | 2774 | RNAseq | -0.0163 | 0.9606 | |
| SRP159526 | GNAL | 2774 | RNAseq | -0.0262 | 0.9422 | |
| SRP193095 | GNAL | 2774 | RNAseq | 0.0697 | 0.6612 | |
| SRP219564 | GNAL | 2774 | RNAseq | -0.2567 | 0.7080 | |
| TCGA | GNAL | 2774 | RNAseq | -0.3200 | 0.1007 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by GNAL expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GNAL:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GNAL | 2774 | 5 | 3 | 22 | |
| GSE20123 | GNAL | 2774 | 5 | 3 | 22 | |
| GSE43470 | GNAL | 2774 | 1 | 6 | 36 | |
| GSE46452 | GNAL | 2774 | 3 | 21 | 35 | |
| GSE47630 | GNAL | 2774 | 7 | 17 | 16 | |
| GSE54993 | GNAL | 2774 | 6 | 2 | 62 | |
| GSE54994 | GNAL | 2774 | 8 | 8 | 37 | |
| GSE60625 | GNAL | 2774 | 0 | 4 | 7 | |
| GSE74703 | GNAL | 2774 | 1 | 4 | 31 | |
| GSE74704 | GNAL | 2774 | 3 | 2 | 15 | |
| TCGA | GNAL | 2774 | 29 | 23 | 44 |
Total number of gains: 68; Total number of losses: 93; Total Number of normals: 327.
Somatic mutations of GNAL:
Generating mutation plots.
Highly correlated genes for GNAL:
Showing top 20/65 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GNAL | FAM181B | 0.711057 | 4 | 0 | 3 |
| GNAL | RASSF6 | 0.688117 | 3 | 0 | 3 |
| GNAL | ZNF639 | 0.667926 | 4 | 0 | 3 |
| GNAL | PIGQ | 0.663636 | 3 | 0 | 3 |
| GNAL | ATOH8 | 0.658256 | 4 | 0 | 4 |
| GNAL | SCLY | 0.648423 | 4 | 0 | 3 |
| GNAL | ZNF569 | 0.646854 | 4 | 0 | 3 |
| GNAL | SYBU | 0.644185 | 4 | 0 | 3 |
| GNAL | PPP1R12C | 0.642312 | 3 | 0 | 3 |
| GNAL | CLCN6 | 0.639021 | 4 | 0 | 3 |
| GNAL | PIEZO2 | 0.629981 | 4 | 0 | 3 |
| GNAL | GSTM5 | 0.623931 | 4 | 0 | 3 |
| GNAL | ACTR3B | 0.620932 | 4 | 0 | 3 |
| GNAL | FAM189B | 0.612663 | 4 | 0 | 3 |
| GNAL | DCLK1 | 0.610954 | 6 | 0 | 5 |
| GNAL | SCN7A | 0.609532 | 4 | 0 | 4 |
| GNAL | VIPR2 | 0.606674 | 5 | 0 | 4 |
| GNAL | ATP7B | 0.60114 | 5 | 0 | 3 |
| GNAL | ALDH1L1 | 0.600595 | 4 | 0 | 3 |
| GNAL | CSRNP3 | 0.598086 | 4 | 0 | 3 |
For details and further investigation, click here
