| Full name: LIF interleukin 6 family cytokine | Alias Symbol: CDF|DIA|HILDA | ||
| Type: protein-coding gene | Cytoband: 22q12.2 | ||
| Entrez ID: 3976 | HGNC ID: HGNC:6596 | Ensembl Gene: ENSG00000128342 | OMIM ID: 159540 |
| Drug and gene relationship at DGIdb | |||
LIF involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04550 | Signaling pathways regulating pluripotency of stem cells | |
| hsa04630 | Jak-STAT signaling pathway |
Expression of LIF:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | LIF | 3976 | 205266_at | 0.2699 | 0.6958 | |
| GSE20347 | LIF | 3976 | 205266_at | 0.1541 | 0.2510 | |
| GSE23400 | LIF | 3976 | 205266_at | 0.1183 | 0.1118 | |
| GSE26886 | LIF | 3976 | 205266_at | 1.0071 | 0.0024 | |
| GSE29001 | LIF | 3976 | 205266_at | 0.3132 | 0.3939 | |
| GSE38129 | LIF | 3976 | 205266_at | 0.2147 | 0.1859 | |
| GSE45670 | LIF | 3976 | 205266_at | 0.1524 | 0.6033 | |
| GSE53622 | LIF | 3976 | 72125 | 0.5387 | 0.0127 | |
| GSE53624 | LIF | 3976 | 72125 | 0.6418 | 0.0004 | |
| GSE63941 | LIF | 3976 | 205266_at | -2.6145 | 0.0085 | |
| GSE77861 | LIF | 3976 | 205266_at | 0.4773 | 0.2389 | |
| GSE97050 | LIF | 3976 | A_24_P233488 | 0.2338 | 0.3879 | |
| SRP007169 | LIF | 3976 | RNAseq | 2.0431 | 0.0112 | |
| SRP008496 | LIF | 3976 | RNAseq | 3.0316 | 0.0000 | |
| SRP064894 | LIF | 3976 | RNAseq | 0.5125 | 0.3263 | |
| SRP133303 | LIF | 3976 | RNAseq | 0.0312 | 0.9225 | |
| SRP159526 | LIF | 3976 | RNAseq | 1.2809 | 0.0000 | |
| SRP193095 | LIF | 3976 | RNAseq | 2.2390 | 0.0000 | |
| SRP219564 | LIF | 3976 | RNAseq | 1.7271 | 0.0056 | |
| TCGA | LIF | 3976 | RNAseq | 0.3482 | 0.0570 |
Upregulated datasets: 6; Downregulated datasets: 1.
Survival by LIF expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of LIF:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | LIF | 3976 | 5 | 5 | 20 | |
| GSE20123 | LIF | 3976 | 5 | 4 | 21 | |
| GSE43470 | LIF | 3976 | 4 | 6 | 33 | |
| GSE46452 | LIF | 3976 | 31 | 1 | 27 | |
| GSE47630 | LIF | 3976 | 8 | 5 | 27 | |
| GSE54993 | LIF | 3976 | 3 | 6 | 61 | |
| GSE54994 | LIF | 3976 | 11 | 8 | 34 | |
| GSE60625 | LIF | 3976 | 5 | 0 | 6 | |
| GSE74703 | LIF | 3976 | 4 | 5 | 27 | |
| GSE74704 | LIF | 3976 | 2 | 1 | 17 | |
| TCGA | LIF | 3976 | 27 | 15 | 54 |
Total number of gains: 105; Total number of losses: 56; Total Number of normals: 327.
Somatic mutations of LIF:
Generating mutation plots.
Highly correlated genes for LIF:
Showing top 20/130 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| LIF | TCTE3 | 0.73899 | 3 | 0 | 3 |
| LIF | IRAK1 | 0.734352 | 3 | 0 | 3 |
| LIF | CFC1 | 0.727161 | 3 | 0 | 3 |
| LIF | FAM186B | 0.725646 | 3 | 0 | 3 |
| LIF | SEZ6L2 | 0.718819 | 4 | 0 | 4 |
| LIF | TTBK1 | 0.713626 | 3 | 0 | 3 |
| LIF | LINC00475 | 0.711579 | 3 | 0 | 3 |
| LIF | GDF15 | 0.705864 | 4 | 0 | 4 |
| LIF | ANO7 | 0.705316 | 4 | 0 | 4 |
| LIF | PICK1 | 0.689453 | 3 | 0 | 3 |
| LIF | HDAC10 | 0.689181 | 3 | 0 | 3 |
| LIF | LINC-PINT | 0.683349 | 3 | 0 | 3 |
| LIF | PHF1 | 0.682902 | 3 | 0 | 3 |
| LIF | ATP8B3 | 0.680188 | 3 | 0 | 3 |
| LIF | ANXA10 | 0.67459 | 4 | 0 | 3 |
| LIF | RASGRF2 | 0.673451 | 4 | 0 | 3 |
| LIF | FAM189B | 0.673049 | 4 | 0 | 4 |
| LIF | ZNF197 | 0.66347 | 3 | 0 | 3 |
| LIF | NLRP5 | 0.6623 | 4 | 0 | 3 |
| LIF | PIP5KL1 | 0.660156 | 4 | 0 | 3 |
For details and further investigation, click here
