| Full name: claudin 16 | Alias Symbol: PCLN1|HOMG3 | ||
| Type: protein-coding gene | Cytoband: 3q28 | ||
| Entrez ID: 10686 | HGNC ID: HGNC:2037 | Ensembl Gene: ENSG00000113946 | OMIM ID: 603959 |
| Drug and gene relationship at DGIdb | |||
CLDN16 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04530 | Tight junction |
Expression of CLDN16:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CLDN16 | 10686 | 220332_at | 0.0211 | 0.9471 | |
| GSE20347 | CLDN16 | 10686 | 220332_at | 0.2311 | 0.0181 | |
| GSE23400 | CLDN16 | 10686 | 220332_at | 0.0366 | 0.4479 | |
| GSE26886 | CLDN16 | 10686 | 220332_at | -0.0275 | 0.8093 | |
| GSE29001 | CLDN16 | 10686 | 220332_at | 0.0197 | 0.9122 | |
| GSE38129 | CLDN16 | 10686 | 220332_at | 0.1762 | 0.0269 | |
| GSE45670 | CLDN16 | 10686 | 220332_at | 0.2317 | 0.0048 | |
| GSE53622 | CLDN16 | 10686 | 141538 | 1.4827 | 0.0000 | |
| GSE53624 | CLDN16 | 10686 | 141538 | 0.6854 | 0.0000 | |
| GSE63941 | CLDN16 | 10686 | 220332_at | 0.2868 | 0.4028 | |
| GSE77861 | CLDN16 | 10686 | 220332_at | -0.0429 | 0.7461 | |
| GSE97050 | CLDN16 | 10686 | A_33_P3314401 | 0.2608 | 0.3495 | |
| SRP133303 | CLDN16 | 10686 | RNAseq | 0.5152 | 0.0477 | |
| SRP159526 | CLDN16 | 10686 | RNAseq | 0.6011 | 0.2248 | |
| SRP219564 | CLDN16 | 10686 | RNAseq | 1.3559 | 0.0527 | |
| TCGA | CLDN16 | 10686 | RNAseq | 2.8460 | 0.0000 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by CLDN16 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CLDN16:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CLDN16 | 10686 | 25 | 0 | 5 | |
| GSE20123 | CLDN16 | 10686 | 25 | 0 | 5 | |
| GSE43470 | CLDN16 | 10686 | 23 | 0 | 20 | |
| GSE46452 | CLDN16 | 10686 | 19 | 1 | 39 | |
| GSE47630 | CLDN16 | 10686 | 27 | 2 | 11 | |
| GSE54993 | CLDN16 | 10686 | 1 | 19 | 50 | |
| GSE54994 | CLDN16 | 10686 | 39 | 0 | 14 | |
| GSE60625 | CLDN16 | 10686 | 0 | 6 | 5 | |
| GSE74703 | CLDN16 | 10686 | 20 | 0 | 16 | |
| GSE74704 | CLDN16 | 10686 | 17 | 0 | 3 | |
| TCGA | CLDN16 | 10686 | 76 | 0 | 20 |
Total number of gains: 272; Total number of losses: 28; Total Number of normals: 188.
Somatic mutations of CLDN16:
Generating mutation plots.
Highly correlated genes for CLDN16:
Showing top 20/394 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CLDN16 | KIR3DL3 | 0.71709 | 5 | 0 | 5 |
| CLDN16 | ODF1 | 0.677413 | 5 | 0 | 4 |
| CLDN16 | NEUROD2 | 0.661512 | 5 | 0 | 4 |
| CLDN16 | ERN1 | 0.656678 | 4 | 0 | 4 |
| CLDN16 | ADAM7 | 0.654759 | 5 | 0 | 5 |
| CLDN16 | RFPL2 | 0.652462 | 6 | 0 | 4 |
| CLDN16 | INE1 | 0.651687 | 4 | 0 | 3 |
| CLDN16 | PATE1 | 0.650646 | 3 | 0 | 3 |
| CLDN16 | KCNA1 | 0.650635 | 5 | 0 | 4 |
| CLDN16 | GAD2 | 0.650135 | 5 | 0 | 4 |
| CLDN16 | CCR8 | 0.648368 | 6 | 0 | 5 |
| CLDN16 | ABCA4 | 0.647579 | 4 | 0 | 4 |
| CLDN16 | PRAMEF12 | 0.646812 | 6 | 0 | 4 |
| CLDN16 | C4BPA | 0.643868 | 7 | 0 | 5 |
| CLDN16 | FAM66D | 0.64355 | 5 | 0 | 4 |
| CLDN16 | PAPPA2 | 0.642064 | 6 | 0 | 6 |
| CLDN16 | SIRPB1 | 0.64138 | 3 | 0 | 3 |
| CLDN16 | PROZ | 0.635623 | 5 | 0 | 4 |
| CLDN16 | FGG | 0.633989 | 5 | 0 | 4 |
| CLDN16 | GLIS3-AS1 | 0.632673 | 3 | 0 | 3 |
For details and further investigation, click here
