| Full name: cytokine dependent hematopoietic cell linker | Alias Symbol: MIST | ||
| Type: protein-coding gene | Cytoband: 4p16.1 | ||
| Entrez ID: 116449 | HGNC ID: HGNC:17438 | Ensembl Gene: ENSG00000109684 | OMIM ID: 611434 |
| Drug and gene relationship at DGIdb | |||
Expression of CLNK:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CLNK | 116449 | 1570239_a_at | -0.1219 | 0.6423 | |
| GSE26886 | CLNK | 116449 | 1570239_a_at | 0.0651 | 0.6875 | |
| GSE45670 | CLNK | 116449 | 1562587_at | 0.0367 | 0.8373 | |
| GSE53622 | CLNK | 116449 | 99835 | -0.4883 | 0.0076 | |
| GSE53624 | CLNK | 116449 | 99835 | -0.7038 | 0.0001 | |
| GSE63941 | CLNK | 116449 | 1570239_a_at | 0.1947 | 0.0572 | |
| GSE77861 | CLNK | 116449 | 1570239_a_at | -0.1448 | 0.1934 | |
| SRP133303 | CLNK | 116449 | RNAseq | -0.5540 | 0.0294 | |
| TCGA | CLNK | 116449 | RNAseq | 0.1416 | 0.8785 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by CLNK expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CLNK:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CLNK | 116449 | 0 | 18 | 12 | |
| GSE20123 | CLNK | 116449 | 0 | 18 | 12 | |
| GSE43470 | CLNK | 116449 | 1 | 15 | 27 | |
| GSE46452 | CLNK | 116449 | 1 | 36 | 22 | |
| GSE47630 | CLNK | 116449 | 1 | 19 | 20 | |
| GSE54993 | CLNK | 116449 | 10 | 0 | 60 | |
| GSE54994 | CLNK | 116449 | 4 | 12 | 37 | |
| GSE60625 | CLNK | 116449 | 0 | 0 | 11 | |
| GSE74703 | CLNK | 116449 | 1 | 13 | 22 | |
| GSE74704 | CLNK | 116449 | 0 | 11 | 9 | |
| TCGA | CLNK | 116449 | 9 | 47 | 40 |
Total number of gains: 27; Total number of losses: 189; Total Number of normals: 272.
Somatic mutations of CLNK:
Generating mutation plots.
Highly correlated genes for CLNK:
Showing top 20/60 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CLNK | TRAT1 | 0.669313 | 3 | 0 | 3 |
| CLNK | CD96 | 0.659448 | 3 | 0 | 3 |
| CLNK | STAP1 | 0.655289 | 3 | 0 | 3 |
| CLNK | ZAP70 | 0.651536 | 3 | 0 | 3 |
| CLNK | PKD1L2 | 0.648787 | 3 | 0 | 3 |
| CLNK | PIK3R6 | 0.641337 | 3 | 0 | 3 |
| CLNK | MROH8 | 0.640716 | 3 | 0 | 3 |
| CLNK | EBI3 | 0.632288 | 3 | 0 | 3 |
| CLNK | LDLRAD4 | 0.627974 | 3 | 0 | 3 |
| CLNK | DEFB118 | 0.622132 | 4 | 0 | 4 |
| CLNK | CNGA4 | 0.619891 | 3 | 0 | 3 |
| CLNK | NAAA | 0.613535 | 3 | 0 | 3 |
| CLNK | LGALS2 | 0.611236 | 3 | 0 | 3 |
| CLNK | MFNG | 0.610041 | 3 | 0 | 3 |
| CLNK | TAGAP | 0.607618 | 4 | 0 | 3 |
| CLNK | LYL1 | 0.604857 | 3 | 0 | 3 |
| CLNK | INPP5D | 0.602298 | 4 | 0 | 3 |
| CLNK | GRPR | 0.594861 | 4 | 0 | 4 |
| CLNK | CYSLTR1 | 0.592367 | 3 | 0 | 3 |
| CLNK | GRAP2 | 0.592192 | 4 | 0 | 3 |
For details and further investigation, click here
