| Full name: low density lipoprotein receptor class A domain containing 4 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 18p11.21 | ||
| Entrez ID: 753 | HGNC ID: HGNC:1224 | Ensembl Gene: ENSG00000168675 | OMIM ID: 606571 |
| Drug and gene relationship at DGIdb | |||
Expression of LDLRAD4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | LDLRAD4 | 753 | 209574_s_at | -0.1375 | 0.8597 | |
| GSE20347 | LDLRAD4 | 753 | 209573_s_at | -0.0154 | 0.8644 | |
| GSE23400 | LDLRAD4 | 753 | 209573_s_at | -0.2633 | 0.0000 | |
| GSE26886 | LDLRAD4 | 753 | 209573_s_at | -0.0510 | 0.8510 | |
| GSE29001 | LDLRAD4 | 753 | 207996_s_at | 1.0026 | 0.0757 | |
| GSE38129 | LDLRAD4 | 753 | 209573_s_at | -0.1180 | 0.2662 | |
| GSE45670 | LDLRAD4 | 753 | 209574_s_at | -0.1874 | 0.5970 | |
| GSE53622 | LDLRAD4 | 753 | 75250 | -0.2310 | 0.2434 | |
| GSE53624 | LDLRAD4 | 753 | 75250 | -0.1391 | 0.3425 | |
| GSE63941 | LDLRAD4 | 753 | 209573_s_at | 0.1819 | 0.3162 | |
| GSE77861 | LDLRAD4 | 753 | 209573_s_at | -0.0217 | 0.8428 | |
| SRP007169 | LDLRAD4 | 753 | RNAseq | 0.9861 | 0.1415 | |
| SRP008496 | LDLRAD4 | 753 | RNAseq | 1.8111 | 0.0009 | |
| SRP064894 | LDLRAD4 | 753 | RNAseq | 0.6695 | 0.0557 | |
| SRP133303 | LDLRAD4 | 753 | RNAseq | 0.4136 | 0.1244 | |
| SRP159526 | LDLRAD4 | 753 | RNAseq | 1.0152 | 0.0534 | |
| SRP193095 | LDLRAD4 | 753 | RNAseq | 0.4727 | 0.0799 | |
| SRP219564 | LDLRAD4 | 753 | RNAseq | 0.1390 | 0.8194 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by LDLRAD4 expression:
 |  |
| GSE53622 | GSE53624 |
Note: Click image to view full size file.
Copy number change of LDLRAD4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | LDLRAD4 | 753 | 5 | 3 | 22 | |
| GSE20123 | LDLRAD4 | 753 | 5 | 3 | 22 | |
| GSE43470 | LDLRAD4 | 753 | 0 | 6 | 37 | |
| GSE46452 | LDLRAD4 | 753 | 3 | 21 | 35 | |
| GSE47630 | LDLRAD4 | 753 | 7 | 17 | 16 | |
| GSE54993 | LDLRAD4 | 753 | 6 | 2 | 62 | |
| GSE54994 | LDLRAD4 | 753 | 8 | 8 | 37 | |
| GSE60625 | LDLRAD4 | 753 | 0 | 4 | 7 | |
| GSE74703 | LDLRAD4 | 753 | 0 | 4 | 32 | |
| GSE74704 | LDLRAD4 | 753 | 3 | 2 | 15 | |
| TCGA | LDLRAD4 | 753 | 28 | 24 | 44 |
Total number of gains: 65; Total number of losses: 94; Total Number of normals: 329.
Somatic mutations of LDLRAD4:
Generating mutation plots.
Highly correlated genes for LDLRAD4:
Showing top 20/227 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| LDLRAD4 | ZFPM2 | 0.754153 | 3 | 0 | 3 |
| LDLRAD4 | GNG2 | 0.675871 | 4 | 0 | 4 |
| LDLRAD4 | PTPRU | 0.655674 | 3 | 0 | 3 |
| LDLRAD4 | LIX1L | 0.647122 | 4 | 0 | 4 |
| LDLRAD4 | JAZF1 | 0.645166 | 3 | 0 | 3 |
| LDLRAD4 | TRIM52-AS1 | 0.641774 | 3 | 0 | 3 |
| LDLRAD4 | RASSF2 | 0.638178 | 4 | 0 | 3 |
| LDLRAD4 | GPR27 | 0.63378 | 3 | 0 | 3 |
| LDLRAD4 | FAM229B | 0.629989 | 3 | 0 | 3 |
| LDLRAD4 | GPR161 | 0.628498 | 3 | 0 | 3 |
| LDLRAD4 | CLNK | 0.627974 | 3 | 0 | 3 |
| LDLRAD4 | KLHL41 | 0.626328 | 3 | 0 | 3 |
| LDLRAD4 | SDC2 | 0.624027 | 3 | 0 | 3 |
| LDLRAD4 | PMP22 | 0.623979 | 5 | 0 | 4 |
| LDLRAD4 | HMCN1 | 0.621949 | 4 | 0 | 3 |
| LDLRAD4 | KLF12 | 0.621632 | 3 | 0 | 3 |
| LDLRAD4 | AXL | 0.62109 | 5 | 0 | 4 |
| LDLRAD4 | RNF130 | 0.619256 | 4 | 0 | 3 |
| LDLRAD4 | TSPAN4 | 0.618724 | 5 | 0 | 3 |
| LDLRAD4 | FRZB | 0.618049 | 6 | 0 | 5 |
For details and further investigation, click here
