| Full name: collagen type II alpha 1 chain | Alias Symbol: STL1 | ||
| Type: protein-coding gene | Cytoband: 12q13.11 | ||
| Entrez ID: 1280 | HGNC ID: HGNC:2200 | Ensembl Gene: ENSG00000139219 | OMIM ID: 120140 |
| Drug and gene relationship at DGIdb | |||
COL2A1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04151 | PI3K-Akt signaling pathway | |
| hsa04510 | Focal adhesion |
Expression of COL2A1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | COL2A1 | 1280 | 213492_at | 1.0018 | 0.3484 | |
| GSE20347 | COL2A1 | 1280 | 217404_s_at | 0.2240 | 0.0002 | |
| GSE23400 | COL2A1 | 1280 | 213492_at | 0.0022 | 0.9557 | |
| GSE26886 | COL2A1 | 1280 | 217404_s_at | 0.3023 | 0.0229 | |
| GSE29001 | COL2A1 | 1280 | 213492_at | 0.3325 | 0.0834 | |
| GSE38129 | COL2A1 | 1280 | 217404_s_at | 0.0623 | 0.6920 | |
| GSE45670 | COL2A1 | 1280 | 217404_s_at | 0.2021 | 0.2245 | |
| GSE53622 | COL2A1 | 1280 | 42915 | 1.5136 | 0.0000 | |
| GSE53624 | COL2A1 | 1280 | 42915 | 2.8534 | 0.0000 | |
| GSE63941 | COL2A1 | 1280 | 217404_s_at | -0.1341 | 0.7676 | |
| GSE77861 | COL2A1 | 1280 | 217404_s_at | -0.0751 | 0.5048 | |
| TCGA | COL2A1 | 1280 | RNAseq | -2.0602 | 0.0004 |
Upregulated datasets: 2; Downregulated datasets: 1.
Survival by COL2A1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of COL2A1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | COL2A1 | 1280 | 7 | 1 | 22 | |
| GSE20123 | COL2A1 | 1280 | 7 | 1 | 22 | |
| GSE43470 | COL2A1 | 1280 | 3 | 1 | 39 | |
| GSE46452 | COL2A1 | 1280 | 8 | 1 | 50 | |
| GSE47630 | COL2A1 | 1280 | 11 | 2 | 27 | |
| GSE54993 | COL2A1 | 1280 | 0 | 5 | 65 | |
| GSE54994 | COL2A1 | 1280 | 6 | 1 | 46 | |
| GSE60625 | COL2A1 | 1280 | 0 | 0 | 11 | |
| GSE74703 | COL2A1 | 1280 | 3 | 1 | 32 | |
| GSE74704 | COL2A1 | 1280 | 4 | 1 | 15 | |
| TCGA | COL2A1 | 1280 | 16 | 12 | 68 |
Total number of gains: 65; Total number of losses: 26; Total Number of normals: 397.
Somatic mutations of COL2A1:
Generating mutation plots.
Highly correlated genes for COL2A1:
Showing top 20/81 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| COL2A1 | CASP14 | 0.682923 | 3 | 0 | 3 |
| COL2A1 | TRPC7 | 0.66134 | 3 | 0 | 3 |
| COL2A1 | SRP19 | 0.651559 | 3 | 0 | 3 |
| COL2A1 | APCDD1L | 0.642013 | 4 | 0 | 3 |
| COL2A1 | SLC5A3 | 0.634765 | 4 | 0 | 3 |
| COL2A1 | RUNX1-IT1 | 0.612669 | 4 | 0 | 3 |
| COL2A1 | SEC14L4 | 0.603139 | 3 | 0 | 3 |
| COL2A1 | MEST | 0.595813 | 4 | 0 | 3 |
| COL2A1 | ARHGAP22 | 0.594922 | 4 | 0 | 3 |
| COL2A1 | NAA11 | 0.593409 | 4 | 0 | 3 |
| COL2A1 | PKLR | 0.590253 | 4 | 0 | 3 |
| COL2A1 | ATF5 | 0.586902 | 4 | 0 | 3 |
| COL2A1 | BICD1 | 0.586533 | 4 | 0 | 3 |
| COL2A1 | PLXNA1 | 0.582604 | 5 | 0 | 5 |
| COL2A1 | PKNOX1 | 0.576513 | 4 | 0 | 3 |
| COL2A1 | GNGT1 | 0.574639 | 6 | 0 | 3 |
| COL2A1 | C14orf119 | 0.569323 | 3 | 0 | 3 |
| COL2A1 | KCNT1 | 0.569136 | 3 | 0 | 3 |
| COL2A1 | SPINK1 | 0.568916 | 4 | 0 | 3 |
| COL2A1 | FANCA | 0.568542 | 5 | 0 | 3 |
For details and further investigation, click here
