| Full name: serine peptidase inhibitor, Kazal type 1 | Alias Symbol: Spink3|PCTT|PSTI|TATI | ||
| Type: protein-coding gene | Cytoband: 5q32 | ||
| Entrez ID: 6690 | HGNC ID: HGNC:11244 | Ensembl Gene: ENSG00000164266 | OMIM ID: 167790 |
| Drug and gene relationship at DGIdb | |||
Expression of SPINK1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SPINK1 | 6690 | 206239_s_at | 0.0590 | 0.8948 | |
| GSE20347 | SPINK1 | 6690 | 206239_s_at | 0.0191 | 0.9142 | |
| GSE23400 | SPINK1 | 6690 | 206239_s_at | -0.1727 | 0.1609 | |
| GSE26886 | SPINK1 | 6690 | 206239_s_at | 0.6333 | 0.0040 | |
| GSE29001 | SPINK1 | 6690 | 206239_s_at | 0.2424 | 0.1700 | |
| GSE38129 | SPINK1 | 6690 | 206239_s_at | -0.5926 | 0.2155 | |
| GSE45670 | SPINK1 | 6690 | 206239_s_at | 0.1956 | 0.1455 | |
| GSE53622 | SPINK1 | 6690 | 132888 | 1.1468 | 0.0021 | |
| GSE53624 | SPINK1 | 6690 | 132888 | 1.1412 | 0.0002 | |
| GSE63941 | SPINK1 | 6690 | 206239_s_at | -0.3719 | 0.2422 | |
| GSE77861 | SPINK1 | 6690 | 206239_s_at | 0.2111 | 0.2367 | |
| SRP133303 | SPINK1 | 6690 | RNAseq | 0.7517 | 0.0327 | |
| TCGA | SPINK1 | 6690 | RNAseq | -3.8193 | 0.0000 |
Upregulated datasets: 2; Downregulated datasets: 1.
Survival by SPINK1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SPINK1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SPINK1 | 6690 | 1 | 12 | 17 | |
| GSE20123 | SPINK1 | 6690 | 1 | 12 | 17 | |
| GSE43470 | SPINK1 | 6690 | 2 | 9 | 32 | |
| GSE46452 | SPINK1 | 6690 | 0 | 27 | 32 | |
| GSE47630 | SPINK1 | 6690 | 0 | 20 | 20 | |
| GSE54993 | SPINK1 | 6690 | 9 | 1 | 60 | |
| GSE54994 | SPINK1 | 6690 | 2 | 15 | 36 | |
| GSE60625 | SPINK1 | 6690 | 0 | 0 | 11 | |
| GSE74703 | SPINK1 | 6690 | 2 | 7 | 27 | |
| GSE74704 | SPINK1 | 6690 | 1 | 7 | 12 | |
| TCGA | SPINK1 | 6690 | 5 | 38 | 53 |
Total number of gains: 23; Total number of losses: 148; Total Number of normals: 317.
Somatic mutations of SPINK1:
Generating mutation plots.
Highly correlated genes for SPINK1:
Showing top 20/39 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SPINK1 | GKN1 | 0.772076 | 5 | 0 | 5 |
| SPINK1 | LIPF | 0.761724 | 6 | 0 | 6 |
| SPINK1 | CTSE | 0.713828 | 5 | 0 | 4 |
| SPINK1 | SEC62 | 0.700776 | 3 | 0 | 3 |
| SPINK1 | REG1A | 0.689292 | 5 | 0 | 5 |
| SPINK1 | LGALS4 | 0.678619 | 5 | 0 | 4 |
| SPINK1 | MUC6 | 0.677037 | 5 | 0 | 4 |
| SPINK1 | B3GNT5 | 0.656757 | 3 | 0 | 3 |
| SPINK1 | TFF2 | 0.651015 | 5 | 0 | 3 |
| SPINK1 | GC | 0.634885 | 4 | 0 | 3 |
| SPINK1 | GRM3 | 0.628751 | 3 | 0 | 3 |
| SPINK1 | MRPL47 | 0.626702 | 3 | 0 | 3 |
| SPINK1 | MTX1 | 0.621186 | 3 | 0 | 3 |
| SPINK1 | IGFN1 | 0.619107 | 3 | 0 | 3 |
| SPINK1 | PLA2G1B | 0.610631 | 4 | 0 | 3 |
| SPINK1 | KCTD13 | 0.608251 | 4 | 0 | 3 |
| SPINK1 | ALDOB | 0.602944 | 3 | 0 | 3 |
| SPINK1 | DGKD | 0.60058 | 5 | 0 | 3 |
| SPINK1 | ATP4A | 0.600326 | 6 | 0 | 4 |
| SPINK1 | CHIA | 0.599742 | 6 | 0 | 4 |
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