| Full name: FA complementation group A | Alias Symbol: FAA|FA-H|FAH | ||
| Type: protein-coding gene | Cytoband: 16q24.3 | ||
| Entrez ID: 2175 | HGNC ID: HGNC:3582 | Ensembl Gene: ENSG00000187741 | OMIM ID: 607139 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
FANCA involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa03460 | Fanconi anemia pathway |
Expression of FANCA:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | FANCA | 2175 | 203805_s_at | 1.0301 | 0.0276 | |
| GSE20347 | FANCA | 2175 | 203805_s_at | 0.7042 | 0.0000 | |
| GSE23400 | FANCA | 2175 | 203805_s_at | 0.3478 | 0.0000 | |
| GSE26886 | FANCA | 2175 | 215530_at | 0.1178 | 0.3382 | |
| GSE29001 | FANCA | 2175 | 203805_s_at | 0.3102 | 0.0504 | |
| GSE38129 | FANCA | 2175 | 203805_s_at | 0.6965 | 0.0000 | |
| GSE45670 | FANCA | 2175 | 203806_s_at | 0.4901 | 0.0000 | |
| GSE53622 | FANCA | 2175 | 95392 | 1.4651 | 0.0000 | |
| GSE53624 | FANCA | 2175 | 155093 | 1.6025 | 0.0000 | |
| GSE63941 | FANCA | 2175 | 203805_s_at | 0.8164 | 0.0117 | |
| GSE77861 | FANCA | 2175 | 215530_at | -0.2346 | 0.0608 | |
| GSE97050 | FANCA | 2175 | A_33_P3386344 | 0.5712 | 0.1449 | |
| SRP007169 | FANCA | 2175 | RNAseq | 2.5142 | 0.0000 | |
| SRP008496 | FANCA | 2175 | RNAseq | 2.1092 | 0.0000 | |
| SRP064894 | FANCA | 2175 | RNAseq | 1.3950 | 0.0000 | |
| SRP133303 | FANCA | 2175 | RNAseq | 1.7935 | 0.0000 | |
| SRP159526 | FANCA | 2175 | RNAseq | 1.9828 | 0.0000 | |
| SRP193095 | FANCA | 2175 | RNAseq | 1.2849 | 0.0000 | |
| SRP219564 | FANCA | 2175 | RNAseq | 1.2810 | 0.0458 | |
| TCGA | FANCA | 2175 | RNAseq | 0.9755 | 0.0000 |
Upregulated datasets: 10; Downregulated datasets: 0.
Survival by FANCA expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of FANCA:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | FANCA | 2175 | 4 | 3 | 23 | |
| GSE20123 | FANCA | 2175 | 4 | 3 | 23 | |
| GSE43470 | FANCA | 2175 | 1 | 13 | 29 | |
| GSE46452 | FANCA | 2175 | 38 | 1 | 20 | |
| GSE47630 | FANCA | 2175 | 11 | 9 | 20 | |
| GSE54993 | FANCA | 2175 | 3 | 4 | 63 | |
| GSE54994 | FANCA | 2175 | 9 | 11 | 33 | |
| GSE60625 | FANCA | 2175 | 4 | 0 | 7 | |
| GSE74703 | FANCA | 2175 | 1 | 9 | 26 | |
| GSE74704 | FANCA | 2175 | 3 | 1 | 16 | |
| TCGA | FANCA | 2175 | 26 | 15 | 55 |
Total number of gains: 104; Total number of losses: 69; Total Number of normals: 315.
Somatic mutations of FANCA:
Generating mutation plots.
Highly correlated genes for FANCA:
Showing top 20/555 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| FANCA | RAD54L | 0.75917 | 8 | 0 | 8 |
| FANCA | MTBP | 0.746556 | 6 | 0 | 6 |
| FANCA | DKC1 | 0.739077 | 3 | 0 | 3 |
| FANCA | MMS22L | 0.72491 | 3 | 0 | 3 |
| FANCA | LRP8 | 0.722942 | 6 | 0 | 6 |
| FANCA | LAIR1 | 0.722418 | 4 | 0 | 4 |
| FANCA | ANKRD36 | 0.714483 | 3 | 0 | 3 |
| FANCA | CENPM | 0.709367 | 11 | 0 | 10 |
| FANCA | SLC19A1 | 0.708887 | 3 | 0 | 3 |
| FANCA | FAM89A | 0.705471 | 3 | 0 | 3 |
| FANCA | CCNF | 0.704201 | 11 | 0 | 10 |
| FANCA | SAPCD2 | 0.703875 | 5 | 0 | 5 |
| FANCA | FANCB | 0.696544 | 6 | 0 | 5 |
| FANCA | PYCR2 | 0.695779 | 3 | 0 | 3 |
| FANCA | CENPW | 0.694974 | 6 | 0 | 5 |
| FANCA | ECEL1 | 0.687813 | 3 | 0 | 3 |
| FANCA | CDC25C | 0.682162 | 7 | 0 | 6 |
| FANCA | SNAP47 | 0.681524 | 3 | 0 | 3 |
| FANCA | CHEK1 | 0.679971 | 10 | 0 | 9 |
| FANCA | ZGRF1 | 0.67544 | 5 | 0 | 4 |
For details and further investigation, click here
