ISLR

 

Full name: immunoglobulin superfamily containing leucine rich repeat Alias Symbol: HsT17563
Type: protein-coding gene Cytoband: 15q24.1
Entrez ID: 3671 HGNC ID: HGNC:6133 Ensembl Gene: ENSG00000129009 OMIM ID: 602059
Drug and gene relationship at DGIdb

 

Expression of ISLR:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 ISLR 3671 207191_s_at 0.5293 0.6846
GSE20347 ISLR 3671 207191_s_at 1.3166 0.0000
GSE23400 ISLR 3671 207191_s_at 0.6599 0.0001
GSE26886 ISLR 3671 207191_s_at 1.0716 0.0000
GSE29001 ISLR 3671 207191_s_at 0.4948 0.1905
GSE38129 ISLR 3671 207191_s_at 1.0312 0.0149
GSE45670 ISLR 3671 207191_s_at -0.4673 0.1936
GSE53622 ISLR 3671 71913 0.9274 0.0000
GSE53624 ISLR 3671 71913 1.3092 0.0000
GSE63941 ISLR 3671 207191_s_at -2.7580 0.0005
GSE77861 ISLR 3671 207191_s_at 0.3210 0.3133
GSE97050 ISLR 3671 A_23_P3312 0.1633 0.5423
SRP007169 ISLR 3671 RNAseq 4.6489 0.0000
SRP008496 ISLR 3671 RNAseq 5.5177 0.0000
SRP064894 ISLR 3671 RNAseq 2.0069 0.0001
SRP133303 ISLR 3671 RNAseq 1.8116 0.0000
SRP159526 ISLR 3671 RNAseq 1.0490 0.0112
SRP193095 ISLR 3671 RNAseq 3.2233 0.0000
SRP219564 ISLR 3671 RNAseq 0.9102 0.3425
TCGA ISLR 3671 RNAseq 0.2029 0.1551

Upregulated datasets: 10; Downregulated datasets: 1.  


 

Survival by ISLR expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  


Copy number change of ISLR:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 ISLR 3671 9 0 21
GSE20123 ISLR 3671 9 0 21
GSE43470 ISLR 3671 4 6 33
GSE46452 ISLR 3671 3 7 49
GSE47630 ISLR 3671 8 10 22
GSE54993 ISLR 3671 5 6 59
GSE54994 ISLR 3671 5 7 41
GSE60625 ISLR 3671 4 0 7
GSE74703 ISLR 3671 4 3 29
GSE74704 ISLR 3671 5 0 15
TCGA ISLR 3671 13 15 68

Total number of gains: 69; Total number of losses: 54; Total Number of normals: 365.  


 

Somatic mutations of ISLR:

 

Generating mutation plots.

 

Highly correlated genes for ISLR:

 

Showing top 20/1101 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
ISLRAEBP10.81689913013
ISLRPCOLCE0.81411813013
ISLRCOL6A20.8120213013
ISLRDNM3OS0.809841303
ISLRMXRA80.80760213013
ISLRCOL8A10.80525510010
ISLRCOL6A10.80485613013
ISLRHTRA10.78664512012
ISLREFEMP20.78388513013
ISLRSPARC0.78261713013
ISLRCTSK0.78105513012
ISLRLRRC170.77368412012
ISLRRARRES20.77308113013
ISLRVCAN0.77303913013
ISLRSULF10.77235312011
ISLRANGPTL20.77126813013
ISLRCOL6A30.75685713013
ISLRCHN10.75408413013
ISLRPDGFRB0.75062213011
ISLRFKBP70.743812707

For details and further investigation, click here