| Full name: immunoglobulin superfamily containing leucine rich repeat | Alias Symbol: HsT17563 | ||
| Type: protein-coding gene | Cytoband: 15q24.1 | ||
| Entrez ID: 3671 | HGNC ID: HGNC:6133 | Ensembl Gene: ENSG00000129009 | OMIM ID: 602059 |
| Drug and gene relationship at DGIdb | |||
Expression of ISLR:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ISLR | 3671 | 207191_s_at | 0.5293 | 0.6846 | |
| GSE20347 | ISLR | 3671 | 207191_s_at | 1.3166 | 0.0000 | |
| GSE23400 | ISLR | 3671 | 207191_s_at | 0.6599 | 0.0001 | |
| GSE26886 | ISLR | 3671 | 207191_s_at | 1.0716 | 0.0000 | |
| GSE29001 | ISLR | 3671 | 207191_s_at | 0.4948 | 0.1905 | |
| GSE38129 | ISLR | 3671 | 207191_s_at | 1.0312 | 0.0149 | |
| GSE45670 | ISLR | 3671 | 207191_s_at | -0.4673 | 0.1936 | |
| GSE53622 | ISLR | 3671 | 71913 | 0.9274 | 0.0000 | |
| GSE53624 | ISLR | 3671 | 71913 | 1.3092 | 0.0000 | |
| GSE63941 | ISLR | 3671 | 207191_s_at | -2.7580 | 0.0005 | |
| GSE77861 | ISLR | 3671 | 207191_s_at | 0.3210 | 0.3133 | |
| GSE97050 | ISLR | 3671 | A_23_P3312 | 0.1633 | 0.5423 | |
| SRP007169 | ISLR | 3671 | RNAseq | 4.6489 | 0.0000 | |
| SRP008496 | ISLR | 3671 | RNAseq | 5.5177 | 0.0000 | |
| SRP064894 | ISLR | 3671 | RNAseq | 2.0069 | 0.0001 | |
| SRP133303 | ISLR | 3671 | RNAseq | 1.8116 | 0.0000 | |
| SRP159526 | ISLR | 3671 | RNAseq | 1.0490 | 0.0112 | |
| SRP193095 | ISLR | 3671 | RNAseq | 3.2233 | 0.0000 | |
| SRP219564 | ISLR | 3671 | RNAseq | 0.9102 | 0.3425 | |
| TCGA | ISLR | 3671 | RNAseq | 0.2029 | 0.1551 |
Upregulated datasets: 10; Downregulated datasets: 1.
Survival by ISLR expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ISLR:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ISLR | 3671 | 9 | 0 | 21 | |
| GSE20123 | ISLR | 3671 | 9 | 0 | 21 | |
| GSE43470 | ISLR | 3671 | 4 | 6 | 33 | |
| GSE46452 | ISLR | 3671 | 3 | 7 | 49 | |
| GSE47630 | ISLR | 3671 | 8 | 10 | 22 | |
| GSE54993 | ISLR | 3671 | 5 | 6 | 59 | |
| GSE54994 | ISLR | 3671 | 5 | 7 | 41 | |
| GSE60625 | ISLR | 3671 | 4 | 0 | 7 | |
| GSE74703 | ISLR | 3671 | 4 | 3 | 29 | |
| GSE74704 | ISLR | 3671 | 5 | 0 | 15 | |
| TCGA | ISLR | 3671 | 13 | 15 | 68 |
Total number of gains: 69; Total number of losses: 54; Total Number of normals: 365.
Somatic mutations of ISLR:
Generating mutation plots.
Highly correlated genes for ISLR:
Showing top 20/1101 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ISLR | AEBP1 | 0.816899 | 13 | 0 | 13 |
| ISLR | PCOLCE | 0.814118 | 13 | 0 | 13 |
| ISLR | COL6A2 | 0.81202 | 13 | 0 | 13 |
| ISLR | DNM3OS | 0.809841 | 3 | 0 | 3 |
| ISLR | MXRA8 | 0.807602 | 13 | 0 | 13 |
| ISLR | COL8A1 | 0.805255 | 10 | 0 | 10 |
| ISLR | COL6A1 | 0.804856 | 13 | 0 | 13 |
| ISLR | HTRA1 | 0.786645 | 12 | 0 | 12 |
| ISLR | EFEMP2 | 0.783885 | 13 | 0 | 13 |
| ISLR | SPARC | 0.782617 | 13 | 0 | 13 |
| ISLR | CTSK | 0.781055 | 13 | 0 | 12 |
| ISLR | LRRC17 | 0.773684 | 12 | 0 | 12 |
| ISLR | RARRES2 | 0.773081 | 13 | 0 | 13 |
| ISLR | VCAN | 0.773039 | 13 | 0 | 13 |
| ISLR | SULF1 | 0.772353 | 12 | 0 | 11 |
| ISLR | ANGPTL2 | 0.771268 | 13 | 0 | 13 |
| ISLR | COL6A3 | 0.756857 | 13 | 0 | 13 |
| ISLR | CHN1 | 0.754084 | 13 | 0 | 13 |
| ISLR | PDGFRB | 0.750622 | 13 | 0 | 11 |
| ISLR | FKBP7 | 0.743812 | 7 | 0 | 7 |
For details and further investigation, click here
