ANGPTL2

 

Full name: angiopoietin like 2 Alias Symbol: ARP2|HARP
Type: protein-coding gene Cytoband: 9q33.3
Entrez ID: 23452 HGNC ID: HGNC:490 Ensembl Gene: ENSG00000136859 OMIM ID: 605001
Drug and gene relationship at DGIdb

 

Expression of ANGPTL2:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 ANGPTL2 23452 213001_at -0.1678 0.8912
GSE20347 ANGPTL2 23452 213001_at 0.5473 0.0024
GSE23400 ANGPTL2 23452 213001_at 0.3299 0.0045
GSE26886 ANGPTL2 23452 213001_at 1.0234 0.0266
GSE29001 ANGPTL2 23452 213001_at 0.3764 0.1761
GSE38129 ANGPTL2 23452 213001_at 0.2287 0.5260
GSE45670 ANGPTL2 23452 213001_at -0.6517 0.1714
GSE53622 ANGPTL2 23452 13530 0.8490 0.0000
GSE53624 ANGPTL2 23452 13530 0.7115 0.0000
GSE63941 ANGPTL2 23452 213001_at -6.5230 0.0000
GSE77861 ANGPTL2 23452 213001_at 0.2495 0.1666
GSE97050 ANGPTL2 23452 A_33_P3844650 0.5100 0.2152
SRP007169 ANGPTL2 23452 RNAseq 2.4343 0.0000
SRP008496 ANGPTL2 23452 RNAseq 2.5637 0.0000
SRP064894 ANGPTL2 23452 RNAseq 1.0236 0.0003
SRP133303 ANGPTL2 23452 RNAseq 1.1145 0.0019
SRP159526 ANGPTL2 23452 RNAseq 0.2221 0.6150
SRP193095 ANGPTL2 23452 RNAseq 1.5511 0.0000
SRP219564 ANGPTL2 23452 RNAseq 0.3630 0.6186
TCGA ANGPTL2 23452 RNAseq -0.0657 0.5446

Upregulated datasets: 6; Downregulated datasets: 1.  

 

Survival by ANGPTL2 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of ANGPTL2:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 ANGPTL2 23452 6 9 15
GSE20123 ANGPTL2 23452 6 9 15
GSE43470 ANGPTL2 23452 5 6 32
GSE46452 ANGPTL2 23452 6 13 40
GSE47630 ANGPTL2 23452 3 16 21
GSE54993 ANGPTL2 23452 3 3 64
GSE54994 ANGPTL2 23452 12 8 33
GSE60625 ANGPTL2 23452 0 0 11
GSE74703 ANGPTL2 23452 5 4 27
GSE74704 ANGPTL2 23452 3 7 10
TCGA ANGPTL2 23452 27 25 44

Total number of gains: 76; Total number of losses: 100; Total Number of normals: 312.  

 

Somatic mutations of ANGPTL2:

 

Generating mutation plots.

 

Highly correlated genes for ANGPTL2:

 

Showing top 20/1041 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
ANGPTL2DNM3OS0.815734404
ANGPTL2PDGFRB0.79787313013
ANGPTL2COL6A10.78885813012
ANGPTL2COL6A20.78286413013
ANGPTL2AEBP10.78047813013
ANGPTL2COL8A10.77179910010
ANGPTL2ISLR0.77126813013
ANGPTL2FIBIN0.769865505
ANGPTL2PCOLCE0.76984913013
ANGPTL2KDSR0.76931303
ANGPTL2COL12A10.768861909
ANGPTL2CTSK0.76720813011
ANGPTL2FMOD0.76688111011
ANGPTL2SPATA90.766351303
ANGPTL2IRAK30.764838505
ANGPTL2FBN10.76123311010
ANGPTL2MMP20.75655712010
ANGPTL2ZNF250.752908404
ANGPTL2SPARC0.75220513013
ANGPTL2MXRA80.75069313012

For details and further investigation, click here