| Full name: collagen type VI alpha 5 chain | Alias Symbol: FLJ35880|VWA4 | ||
| Type: protein-coding gene | Cytoband: 3q22.1 | ||
| Entrez ID: 256076 | HGNC ID: HGNC:26674 | Ensembl Gene: ENSG00000172752 | OMIM ID: 611916 |
| Drug and gene relationship at DGIdb | |||
COL6A5 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04151 | PI3K-Akt signaling pathway | |
| hsa04510 | Focal adhesion |
Expression of COL6A5:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | COL6A5 | 256076 | 1553835_a_at | -0.9301 | 0.1812 | |
| GSE26886 | COL6A5 | 256076 | 1553835_a_at | -0.3284 | 0.0177 | |
| GSE45670 | COL6A5 | 256076 | 1553835_a_at | -0.2892 | 0.2810 | |
| GSE53622 | COL6A5 | 256076 | 32195 | -1.6195 | 0.0000 | |
| GSE53624 | COL6A5 | 256076 | 32195 | -2.2728 | 0.0000 | |
| GSE63941 | COL6A5 | 256076 | 1553835_a_at | 0.0578 | 0.8448 | |
| GSE77861 | COL6A5 | 256076 | 1553835_a_at | -0.0570 | 0.5495 | |
| GSE97050 | COL6A5 | 256076 | A_23_P404698 | -0.3666 | 0.1616 | |
| SRP133303 | COL6A5 | 256076 | RNAseq | -2.1819 | 0.0003 | |
| SRP159526 | COL6A5 | 256076 | RNAseq | -1.4083 | 0.2025 |
Upregulated datasets: 0; Downregulated datasets: 3.
Survival by COL6A5 expression:
 |  |
| GSE53622 | GSE53624 |
Note: Click image to view full size file.
Copy number change of COL6A5:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | COL6A5 | 256076 | 17 | 0 | 13 | |
| GSE20123 | COL6A5 | 256076 | 17 | 0 | 13 | |
| GSE43470 | COL6A5 | 256076 | 19 | 0 | 24 | |
| GSE46452 | COL6A5 | 256076 | 15 | 4 | 40 | |
| GSE47630 | COL6A5 | 256076 | 18 | 3 | 19 | |
| GSE54993 | COL6A5 | 256076 | 2 | 8 | 60 | |
| GSE54994 | COL6A5 | 256076 | 32 | 3 | 18 | |
| GSE60625 | COL6A5 | 256076 | 0 | 6 | 5 | |
| GSE74703 | COL6A5 | 256076 | 17 | 0 | 19 | |
| GSE74704 | COL6A5 | 256076 | 13 | 0 | 7 | |
| TCGA | COL6A5 | 256076 | 59 | 5 | 32 |
Total number of gains: 209; Total number of losses: 29; Total Number of normals: 250.
Somatic mutations of COL6A5:
Generating mutation plots.
Highly correlated genes for COL6A5:
Showing top 20/422 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| COL6A5 | IL34 | 0.678739 | 3 | 0 | 3 |
| COL6A5 | THSD4 | 0.665943 | 6 | 0 | 6 |
| COL6A5 | CCDC178 | 0.653925 | 4 | 0 | 4 |
| COL6A5 | LUZP2 | 0.651604 | 3 | 0 | 3 |
| COL6A5 | ROBO2 | 0.648178 | 4 | 0 | 4 |
| COL6A5 | CCDC160 | 0.647034 | 3 | 0 | 3 |
| COL6A5 | CLIC3 | 0.642655 | 4 | 0 | 3 |
| COL6A5 | FCER1A | 0.640678 | 6 | 0 | 5 |
| COL6A5 | SERPINB3 | 0.636522 | 3 | 0 | 3 |
| COL6A5 | CA13 | 0.631014 | 3 | 0 | 3 |
| COL6A5 | APOBEC1 | 0.629548 | 3 | 0 | 3 |
| COL6A5 | MMRN1 | 0.629545 | 6 | 0 | 6 |
| COL6A5 | DNASE1L3 | 0.62848 | 6 | 0 | 5 |
| COL6A5 | ZNF536 | 0.621472 | 4 | 0 | 4 |
| COL6A5 | FMO3 | 0.618538 | 5 | 0 | 5 |
| COL6A5 | FUT2 | 0.618267 | 4 | 0 | 3 |
| COL6A5 | ADH1B | 0.617796 | 6 | 0 | 5 |
| COL6A5 | ASAH1 | 0.616087 | 6 | 0 | 4 |
| COL6A5 | SLC6A14 | 0.613835 | 3 | 0 | 3 |
| COL6A5 | RNF208 | 0.610403 | 3 | 0 | 3 |
For details and further investigation, click here
