| Full name: cartilage oligomeric matrix protein | Alias Symbol: MED|THBS5 | ||
| Type: protein-coding gene | Cytoband: 19p13.11 | ||
| Entrez ID: 1311 | HGNC ID: HGNC:2227 | Ensembl Gene: ENSG00000105664 | OMIM ID: 600310 |
| Drug and gene relationship at DGIdb | |||
COMP involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04151 | PI3K-Akt signaling pathway | |
| hsa04510 | Focal adhesion |
Expression of COMP:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | COMP | 1311 | 205713_s_at | -0.0236 | 0.9905 | |
| GSE20347 | COMP | 1311 | 205713_s_at | -0.1050 | 0.5998 | |
| GSE23400 | COMP | 1311 | 205713_s_at | 0.2123 | 0.0729 | |
| GSE26886 | COMP | 1311 | 205713_s_at | 0.9295 | 0.0204 | |
| GSE29001 | COMP | 1311 | 205713_s_at | 0.0978 | 0.8834 | |
| GSE38129 | COMP | 1311 | 205713_s_at | 0.3032 | 0.2588 | |
| GSE45670 | COMP | 1311 | 205713_s_at | -0.8320 | 0.0023 | |
| GSE53622 | COMP | 1311 | 132905 | 0.5430 | 0.0694 | |
| GSE53624 | COMP | 1311 | 132905 | 0.5790 | 0.0083 | |
| GSE63941 | COMP | 1311 | 205713_s_at | -1.7917 | 0.0117 | |
| GSE77861 | COMP | 1311 | 205713_s_at | -0.0813 | 0.5141 | |
| GSE97050 | COMP | 1311 | A_24_P264943 | 0.6244 | 0.1816 | |
| SRP133303 | COMP | 1311 | RNAseq | 0.8852 | 0.1418 | |
| SRP159526 | COMP | 1311 | RNAseq | 2.5626 | 0.0017 | |
| TCGA | COMP | 1311 | RNAseq | 0.7464 | 0.1528 |
Upregulated datasets: 1; Downregulated datasets: 1.
Survival by COMP expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of COMP:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | COMP | 1311 | 4 | 5 | 21 | |
| GSE20123 | COMP | 1311 | 3 | 3 | 24 | |
| GSE43470 | COMP | 1311 | 2 | 5 | 36 | |
| GSE46452 | COMP | 1311 | 47 | 1 | 11 | |
| GSE47630 | COMP | 1311 | 5 | 8 | 27 | |
| GSE54993 | COMP | 1311 | 16 | 4 | 50 | |
| GSE54994 | COMP | 1311 | 6 | 13 | 34 | |
| GSE60625 | COMP | 1311 | 9 | 0 | 2 | |
| GSE74703 | COMP | 1311 | 2 | 3 | 31 | |
| GSE74704 | COMP | 1311 | 0 | 3 | 17 | |
| TCGA | COMP | 1311 | 16 | 10 | 70 |
Total number of gains: 110; Total number of losses: 55; Total Number of normals: 323.
Somatic mutations of COMP:
Generating mutation plots.
Highly correlated genes for COMP:
Showing top 20/122 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| COMP | COL5A3 | 0.707066 | 3 | 0 | 3 |
| COMP | ADH1B | 0.673314 | 3 | 0 | 3 |
| COMP | ABCA8 | 0.65806 | 3 | 0 | 3 |
| COMP | LIMD2 | 0.646479 | 3 | 0 | 3 |
| COMP | FCN1 | 0.644113 | 4 | 0 | 4 |
| COMP | GDF11 | 0.635782 | 4 | 0 | 4 |
| COMP | TMEM51-AS1 | 0.63357 | 3 | 0 | 3 |
| COMP | ORM1 | 0.630199 | 3 | 0 | 3 |
| COMP | LAT | 0.625003 | 3 | 0 | 3 |
| COMP | HMCN2 | 0.61351 | 3 | 0 | 3 |
| COMP | CLDN5 | 0.61297 | 4 | 0 | 4 |
| COMP | F10 | 0.606032 | 4 | 0 | 3 |
| COMP | SIGLEC1 | 0.601438 | 6 | 0 | 4 |
| COMP | RSPO1 | 0.601068 | 4 | 0 | 4 |
| COMP | LGI2 | 0.598466 | 5 | 0 | 5 |
| COMP | BATF | 0.593946 | 3 | 0 | 3 |
| COMP | C11orf96 | 0.58971 | 4 | 0 | 3 |
| COMP | PRDM8 | 0.588562 | 4 | 0 | 3 |
| COMP | SLIT3 | 0.58566 | 5 | 0 | 4 |
| COMP | SFRP2 | 0.585243 | 7 | 0 | 6 |
For details and further investigation, click here
