CREB3L3

 

Full name: cAMP responsive element binding protein 3 like 3 Alias Symbol: CREB-H|CREBH
Type: protein-coding gene Cytoband: 19p13.3
Entrez ID: 84699 HGNC ID: HGNC:18855 Ensembl Gene: ENSG00000060566 OMIM ID: 611998
Drug and gene relationship at DGIdb
Screen Evidence:
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

CREB3L3 involved pathways:

KEGG pathway Description View
hsa04022cGMP-PKG signaling pathway
hsa04024cAMP signaling pathway
hsa04151PI3K-Akt signaling pathway
hsa04152AMPK signaling pathway
hsa04261Adrenergic signaling in cardiomyocytes
hsa04668TNF signaling pathway
hsa04725Cholinergic synapse
hsa04728Dopaminergic synapse
hsa04911Insulin secretion
hsa04915Estrogen signaling pathway
hsa04916Melanogenesis
hsa04918Thyroid hormone synthesis
hsa04922Glucagon signaling pathway
hsa04925Aldosterone synthesis and secretion
hsa04931Insulin resistance
hsa04962Vasopressin-regulated water reabsorption
hsa05030Cocaine addiction
hsa05031Amphetamine addiction
hsa05034Alcoholism
hsa05161Hepatitis B
hsa05215Prostate cancer

 

Expression of CREB3L3:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 CREB3L3 84699 234361_at -0.0787 0.6995
GSE26886 CREB3L3 84699 234361_at 0.0657 0.6599
GSE45670 CREB3L3 84699 234361_at -0.0773 0.4803
GSE53622 CREB3L3 84699 28885 0.0988 0.4409
GSE53624 CREB3L3 84699 28885 -0.1620 0.3116
GSE63941 CREB3L3 84699 234361_at 0.1040 0.5403
GSE77861 CREB3L3 84699 234361_at 0.0014 0.9895
GSE97050 CREB3L3 84699 A_23_P108082 0.1476 0.4466
TCGA CREB3L3 84699 RNAseq -2.9484 0.0000

Upregulated datasets: 0; Downregulated datasets: 1.  

 

Survival by CREB3L3 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of CREB3L3:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 CREB3L3 84699 5 3 22
GSE20123 CREB3L3 84699 4 2 24
GSE43470 CREB3L3 84699 1 8 34
GSE46452 CREB3L3 84699 47 1 11
GSE47630 CREB3L3 84699 5 7 28
GSE54993 CREB3L3 84699 16 3 51
GSE54994 CREB3L3 84699 6 16 31
GSE60625 CREB3L3 84699 9 0 2
GSE74703 CREB3L3 84699 1 5 30
GSE74704 CREB3L3 84699 1 2 17
TCGA CREB3L3 84699 11 18 67

Total number of gains: 106; Total number of losses: 65; Total Number of normals: 317.  

 

Somatic mutations of CREB3L3:

 

Generating mutation plots.

 

Highly correlated genes for CREB3L3:

 

Showing top 20/246 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
CREB3L3KRTAP10-120.729331303
CREB3L3EFCAB50.71887303
CREB3L3RBAKDN0.714399303
CREB3L3CLTCL10.713402303
CREB3L3POLM0.710651303
CREB3L3LGALS120.708595403
CREB3L3STRC0.708141303
CREB3L3BAALC0.705137303
CREB3L3YY20.702506303
CREB3L3CASC180.697015303
CREB3L3S1PR40.693892303
CREB3L3KRT730.692733303
CREB3L3DCDC10.691736303
CREB3L3PLA2G2C0.685617303
CREB3L3OR10AD10.682974303
CREB3L3LRSAM10.680435303
CREB3L3PAX20.680079404
CREB3L3PGP0.679779303
CREB3L3CASC150.678303
CREB3L3SHANK2-AS30.677756303

For details and further investigation, click here