Full name: CREB binding protein	Alias Symbol: RTS|CBP|KAT3A
Type: protein-coding gene	Cytoband: 16p13.3
Entrez ID: 1387	HGNC ID: HGNC:2348	Ensembl Gene: ENSG00000005339	OMIM ID: 600140
Drug and gene relationship at DGIdb
Screen Evidence: Knocking out of this gene by CRIPR/Cas9 screen found 10/325 cell lines had fitness change in Project Score. This gene has been idenfitied as a common driver in this paper. Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

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CREBBP involved pathways:

KEGG pathway	Description	View
hsa04024	cAMP signaling pathway	View
hsa04066	HIF-1 signaling pathway	View
hsa04110	Cell cycle	View
hsa04310	Wnt signaling pathway	View
hsa04330	Notch signaling pathway	View
hsa04350	TGF-beta signaling pathway	View
hsa04630	Jak-STAT signaling pathway	View
hsa04720	Long-term potentiation	View
hsa04916	Melanogenesis	View
hsa04922	Glucagon signaling pathway	View
hsa05161	Hepatitis B	View
hsa05166	HTLV-I infection	View
hsa05200	Pathways in cancer	View
hsa05211	Renal cell carcinoma	View
hsa05215	Prostate cancer	View

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Expression of CREBBP:

 

Dataset	Gene	EntrezID	Probe	Log2FC	Adj.pValue	Expression
GSE17351	CREBBP	1387	202160_at	-0.0335	0.9602	Show
GSE20347	CREBBP	1387	202160_at	0.1670	0.0449	Show
GSE23400	CREBBP	1387	202160_at	0.2132	0.0061	Show
GSE26886	CREBBP	1387	202160_at	0.1508	0.5089	Show
GSE29001	CREBBP	1387	202160_at	0.3219	0.0462	Show
GSE38129	CREBBP	1387	202160_at	0.0445	0.5890	Show
GSE45670	CREBBP	1387	202160_at	-0.0052	0.9795	Show
GSE53622	CREBBP	1387	84460	-0.2519	0.0104	Show
GSE53624	CREBBP	1387	84460	0.0006	0.9954	Show
GSE63941	CREBBP	1387	202160_at	0.4307	0.2376	Show
GSE77861	CREBBP	1387	202160_at	-0.0526	0.8959	Show
GSE97050	CREBBP	1387	A_33_P3240229	-0.1765	0.4395	Show
SRP007169	CREBBP	1387	RNAseq	1.0639	0.0030	Show
SRP008496	CREBBP	1387	RNAseq	1.0608	0.0000	Show
SRP064894	CREBBP	1387	RNAseq	-0.1293	0.4462	Show
SRP133303	CREBBP	1387	RNAseq	0.2560	0.1033	Show
SRP159526	CREBBP	1387	RNAseq	0.2102	0.4310	Show
SRP193095	CREBBP	1387	RNAseq	0.2011	0.0443	Show
SRP219564	CREBBP	1387	RNAseq	-0.0058	0.9789	Show
TCGA	CREBBP	1387	RNAseq	-0.0220	0.5846	Show

Upregulated datasets: 2; Downregulated datasets: 0.  Download Data

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Survival by CREBBP expression:

 

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Copy number change of CREBBP:

 

Dataset	Gene	EntrezID	Gain	Loss	Normal	Detail
GSE15526	CREBBP	1387	5	6	19	Show
GSE20123	CREBBP	1387	5	4	21	Show
GSE43470	CREBBP	1387	5	6	32	Show
GSE46452	CREBBP	1387	38	1	20	Show
GSE47630	CREBBP	1387	13	6	21	Show
GSE54993	CREBBP	1387	3	5	62	Show
GSE54994	CREBBP	1387	5	9	39	Show
GSE60625	CREBBP	1387	4	0	7	Show
GSE74703	CREBBP	1387	5	4	27	Show
GSE74704	CREBBP	1387	3	3	14	Show
TCGA	CREBBP	1387	19	15	62	Show

Total number of gains: 105; Total number of losses: 59; Total Number of normals: 324.  Download Data

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Somatic mutations of CREBBP:

 

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Highly correlated genes for CREBBP:

 

Showing top 20/271 corelated genes with mean PCC>0.5.

Gene1	Gene2	Mean PCC	Num. Datasets	Num. PCC<0	Num. PCC>0.5
CREBBP	SLC25A40	0.798202	3	0	3
CREBBP	PCTP	0.787414	3	0	3
CREBBP	COG1	0.783789	3	0	3
CREBBP	C21orf91	0.75309	4	0	4
CREBBP	NDN	0.751761	3	0	3
CREBBP	ARMCX6	0.746572	3	0	3
CREBBP	TCEANC2	0.745277	3	0	3
CREBBP	EEA1	0.737893	3	0	3
CREBBP	TRAPPC8	0.735151	3	0	3
CREBBP	SAE1	0.732258	3	0	3
CREBBP	INSIG1	0.729834	3	0	3
CREBBP	KMT2C	0.728573	3	0	3
CREBBP	PPCS	0.728129	3	0	3
CREBBP	ZYG11B	0.725967	4	0	4
CREBBP	TXNDC16	0.724138	3	0	3
CREBBP	CNOT10	0.716384	3	0	3
CREBBP	PRPF38A	0.706728	4	0	3
CREBBP	MED1	0.701321	3	0	3
CREBBP	USP34	0.699359	4	0	3
CREBBP	IFT52	0.696996	4	0	4

For details and further investigation, click here