| Full name: crystallin lambda 1 | Alias Symbol: GDH|lambda-CRY|MGC149525|MGC149526 | ||
| Type: protein-coding gene | Cytoband: 13q12.11 | ||
| Entrez ID: 51084 | HGNC ID: HGNC:18246 | Ensembl Gene: ENSG00000165475 | OMIM ID: 609877 |
| Drug and gene relationship at DGIdb | |||
Expression of CRYL1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CRYL1 | 51084 | 220753_s_at | -1.2622 | 0.0171 | |
| GSE20347 | CRYL1 | 51084 | 220753_s_at | -1.7660 | 0.0000 | |
| GSE23400 | CRYL1 | 51084 | 220753_s_at | -1.0111 | 0.0000 | |
| GSE26886 | CRYL1 | 51084 | 220753_s_at | -1.1650 | 0.0040 | |
| GSE29001 | CRYL1 | 51084 | 220753_s_at | -1.8599 | 0.0000 | |
| GSE38129 | CRYL1 | 51084 | 220753_s_at | -1.6292 | 0.0000 | |
| GSE45670 | CRYL1 | 51084 | 220753_s_at | -0.8771 | 0.0004 | |
| GSE53622 | CRYL1 | 51084 | 29203 | -1.0755 | 0.0000 | |
| GSE53624 | CRYL1 | 51084 | 29203 | -1.5638 | 0.0000 | |
| GSE63941 | CRYL1 | 51084 | 220753_s_at | -0.2361 | 0.6960 | |
| GSE77861 | CRYL1 | 51084 | 220753_s_at | -1.2952 | 0.0002 | |
| GSE97050 | CRYL1 | 51084 | A_23_P162746 | -0.9650 | 0.0772 | |
| SRP007169 | CRYL1 | 51084 | RNAseq | -3.0704 | 0.0000 | |
| SRP008496 | CRYL1 | 51084 | RNAseq | -2.5374 | 0.0000 | |
| SRP064894 | CRYL1 | 51084 | RNAseq | -1.0254 | 0.0000 | |
| SRP133303 | CRYL1 | 51084 | RNAseq | -1.2482 | 0.0000 | |
| SRP159526 | CRYL1 | 51084 | RNAseq | -1.4719 | 0.0126 | |
| SRP193095 | CRYL1 | 51084 | RNAseq | -2.0368 | 0.0000 | |
| SRP219564 | CRYL1 | 51084 | RNAseq | -1.0925 | 0.0147 | |
| TCGA | CRYL1 | 51084 | RNAseq | -0.6673 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 16.
Survival by CRYL1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CRYL1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CRYL1 | 51084 | 1 | 16 | 13 | |
| GSE20123 | CRYL1 | 51084 | 1 | 15 | 14 | |
| GSE43470 | CRYL1 | 51084 | 1 | 13 | 29 | |
| GSE46452 | CRYL1 | 51084 | 0 | 33 | 26 | |
| GSE47630 | CRYL1 | 51084 | 3 | 26 | 11 | |
| GSE54993 | CRYL1 | 51084 | 11 | 2 | 57 | |
| GSE54994 | CRYL1 | 51084 | 1 | 13 | 39 | |
| GSE60625 | CRYL1 | 51084 | 0 | 3 | 8 | |
| GSE74703 | CRYL1 | 51084 | 1 | 10 | 25 | |
| GSE74704 | CRYL1 | 51084 | 0 | 13 | 7 | |
| TCGA | CRYL1 | 51084 | 7 | 42 | 47 |
Total number of gains: 26; Total number of losses: 186; Total Number of normals: 276.
Somatic mutations of CRYL1:
Generating mutation plots.
Highly correlated genes for CRYL1:
Showing top 20/1913 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CRYL1 | PINK1 | 0.852181 | 8 | 0 | 8 |
| CRYL1 | UBL3 | 0.827229 | 10 | 0 | 10 |
| CRYL1 | KAT2B | 0.802762 | 11 | 0 | 11 |
| CRYL1 | GPD1L | 0.794585 | 11 | 0 | 11 |
| CRYL1 | RMND5B | 0.793786 | 11 | 0 | 11 |
| CRYL1 | CLEC3B | 0.790107 | 3 | 0 | 3 |
| CRYL1 | MGLL | 0.783799 | 11 | 0 | 11 |
| CRYL1 | ACOX3 | 0.782335 | 10 | 0 | 10 |
| CRYL1 | DOCK9 | 0.782041 | 11 | 0 | 11 |
| CRYL1 | PRKCE | 0.781294 | 4 | 0 | 4 |
| CRYL1 | SORT1 | 0.77996 | 11 | 0 | 11 |
| CRYL1 | ANO10 | 0.77878 | 10 | 0 | 10 |
| CRYL1 | SASH1 | 0.778419 | 11 | 0 | 11 |
| CRYL1 | ACAA1 | 0.776941 | 8 | 0 | 7 |
| CRYL1 | GALNT12 | 0.776814 | 11 | 0 | 11 |
| CRYL1 | FAM214A | 0.776203 | 6 | 0 | 6 |
| CRYL1 | HPGD | 0.773134 | 11 | 0 | 10 |
| CRYL1 | NUCB2 | 0.772441 | 11 | 0 | 11 |
| CRYL1 | PPP1R3C | 0.771453 | 11 | 0 | 10 |
| CRYL1 | ARHGEF10L | 0.771307 | 10 | 0 | 10 |
For details and further investigation, click here
