| Full name: SLIT-ROBO Rho GTPase activating protein 2 | Alias Symbol: KIAA0456|ARHGAP34|SRGAP2A | ||
| Type: protein-coding gene | Cytoband: 1q32.1 | ||
| Entrez ID: 23380 | HGNC ID: HGNC:19751 | Ensembl Gene: ENSG00000266028 | OMIM ID: 606524 |
| Drug and gene relationship at DGIdb | |||
SRGAP2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04360 | Axon guidance |
Expression of SRGAP2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SRGAP2 | 23380 | 1556203_a_at | -0.7235 | 0.2874 | |
| GSE26886 | SRGAP2 | 23380 | 1556202_at | -0.0969 | 0.5512 | |
| GSE45670 | SRGAP2 | 23380 | 1556203_a_at | -0.4472 | 0.0014 | |
| GSE53622 | SRGAP2 | 23380 | 78787 | -0.7186 | 0.0000 | |
| GSE53624 | SRGAP2 | 23380 | 48838 | 0.2991 | 0.0000 | |
| GSE63941 | SRGAP2 | 23380 | 1556203_a_at | 0.6178 | 0.1891 | |
| GSE77861 | SRGAP2 | 23380 | 1556202_at | 0.1729 | 0.2493 | |
| GSE97050 | SRGAP2 | 23380 | A_32_P50123 | 0.2861 | 0.1872 | |
| SRP007169 | SRGAP2 | 23380 | RNAseq | 1.2932 | 0.0108 | |
| SRP008496 | SRGAP2 | 23380 | RNAseq | 1.7998 | 0.0000 | |
| SRP064894 | SRGAP2 | 23380 | RNAseq | 0.4905 | 0.0039 | |
| SRP133303 | SRGAP2 | 23380 | RNAseq | 0.1684 | 0.3123 | |
| SRP159526 | SRGAP2 | 23380 | RNAseq | 0.1514 | 0.5840 | |
| SRP193095 | SRGAP2 | 23380 | RNAseq | 0.4343 | 0.0007 | |
| SRP219564 | SRGAP2 | 23380 | RNAseq | 0.3406 | 0.3927 | |
| TCGA | SRGAP2 | 23380 | RNAseq | 0.1793 | 0.0006 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by SRGAP2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SRGAP2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SRGAP2 | 23380 | 11 | 0 | 19 | |
| GSE20123 | SRGAP2 | 23380 | 11 | 0 | 19 | |
| GSE43470 | SRGAP2 | 23380 | 7 | 0 | 36 | |
| GSE46452 | SRGAP2 | 23380 | 3 | 1 | 55 | |
| GSE47630 | SRGAP2 | 23380 | 14 | 0 | 26 | |
| GSE54993 | SRGAP2 | 23380 | 0 | 6 | 64 | |
| GSE54994 | SRGAP2 | 23380 | 14 | 0 | 39 | |
| GSE60625 | SRGAP2 | 23380 | 0 | 0 | 11 | |
| GSE74703 | SRGAP2 | 23380 | 7 | 0 | 29 | |
| GSE74704 | SRGAP2 | 23380 | 5 | 0 | 15 | |
| TCGA | SRGAP2 | 23380 | 44 | 6 | 46 |
Total number of gains: 116; Total number of losses: 13; Total Number of normals: 359.
Somatic mutations of SRGAP2:
Generating mutation plots.
Highly correlated genes for SRGAP2:
Showing top 20/128 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SRGAP2 | TMEM220 | 0.778556 | 3 | 0 | 3 |
| SRGAP2 | CSNK1A1 | 0.734752 | 3 | 0 | 3 |
| SRGAP2 | ZZEF1 | 0.722112 | 4 | 0 | 3 |
| SRGAP2 | LMNA | 0.707103 | 3 | 0 | 3 |
| SRGAP2 | TSC22D2 | 0.706719 | 3 | 0 | 3 |
| SRGAP2 | XPC | 0.697211 | 3 | 0 | 3 |
| SRGAP2 | KIAA0753 | 0.695514 | 3 | 0 | 3 |
| SRGAP2 | TOM1 | 0.691119 | 3 | 0 | 3 |
| SRGAP2 | RBPJ | 0.685027 | 3 | 0 | 3 |
| SRGAP2 | FAM50A | 0.682327 | 3 | 0 | 3 |
| SRGAP2 | ZSWIM6 | 0.677509 | 4 | 0 | 3 |
| SRGAP2 | ZMIZ1 | 0.677065 | 3 | 0 | 3 |
| SRGAP2 | PRDM5 | 0.676506 | 3 | 0 | 3 |
| SRGAP2 | NENF | 0.671691 | 3 | 0 | 3 |
| SRGAP2 | RUFY3 | 0.668817 | 4 | 0 | 3 |
| SRGAP2 | CTF1 | 0.667575 | 3 | 0 | 3 |
| SRGAP2 | ACADVL | 0.667021 | 4 | 0 | 3 |
| SRGAP2 | FKBP8 | 0.664514 | 3 | 0 | 3 |
| SRGAP2 | CRTC2 | 0.66049 | 3 | 0 | 3 |
| SRGAP2 | LYVE1 | 0.65881 | 3 | 0 | 3 |
For details and further investigation, click here
