| Full name: cystatin C | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 20p11.21 | ||
| Entrez ID: 1471 | HGNC ID: HGNC:2475 | Ensembl Gene: ENSG00000101439 | OMIM ID: 604312 |
| Drug and gene relationship at DGIdb | |||
Expression of CST3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CST3 | 1471 | 201360_at | -0.4570 | 0.3093 | |
| GSE20347 | CST3 | 1471 | 201360_at | -0.9425 | 0.0000 | |
| GSE23400 | CST3 | 1471 | 201360_at | -0.6608 | 0.0000 | |
| GSE26886 | CST3 | 1471 | 201360_at | -0.4380 | 0.3119 | |
| GSE29001 | CST3 | 1471 | 201360_at | -0.5334 | 0.2732 | |
| GSE38129 | CST3 | 1471 | 201360_at | -0.9770 | 0.0000 | |
| GSE45670 | CST3 | 1471 | 201360_at | -0.8423 | 0.0011 | |
| GSE53622 | CST3 | 1471 | 59620 | -0.9001 | 0.0000 | |
| GSE53624 | CST3 | 1471 | 59620 | -0.7536 | 0.0000 | |
| GSE63941 | CST3 | 1471 | 201360_at | 0.2920 | 0.7179 | |
| GSE77861 | CST3 | 1471 | 201360_at | -0.4193 | 0.1989 | |
| GSE97050 | CST3 | 1471 | A_33_P3228266 | -0.9037 | 0.0631 | |
| SRP007169 | CST3 | 1471 | RNAseq | -2.2853 | 0.0000 | |
| SRP008496 | CST3 | 1471 | RNAseq | -1.8721 | 0.0000 | |
| SRP064894 | CST3 | 1471 | RNAseq | -0.4113 | 0.4052 | |
| SRP133303 | CST3 | 1471 | RNAseq | -0.8439 | 0.0004 | |
| SRP159526 | CST3 | 1471 | RNAseq | -1.0602 | 0.0000 | |
| SRP193095 | CST3 | 1471 | RNAseq | -0.9586 | 0.0000 | |
| SRP219564 | CST3 | 1471 | RNAseq | -0.3857 | 0.5075 | |
| TCGA | CST3 | 1471 | RNAseq | -0.3140 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 3.
Survival by CST3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CST3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CST3 | 1471 | 12 | 2 | 16 | |
| GSE20123 | CST3 | 1471 | 12 | 2 | 16 | |
| GSE43470 | CST3 | 1471 | 12 | 1 | 30 | |
| GSE46452 | CST3 | 1471 | 27 | 1 | 31 | |
| GSE47630 | CST3 | 1471 | 17 | 4 | 19 | |
| GSE54993 | CST3 | 1471 | 0 | 17 | 53 | |
| GSE54994 | CST3 | 1471 | 26 | 2 | 25 | |
| GSE60625 | CST3 | 1471 | 0 | 0 | 11 | |
| GSE74703 | CST3 | 1471 | 10 | 1 | 25 | |
| GSE74704 | CST3 | 1471 | 7 | 1 | 12 | |
| TCGA | CST3 | 1471 | 43 | 10 | 43 |
Total number of gains: 166; Total number of losses: 41; Total Number of normals: 281.
Somatic mutations of CST3:
Generating mutation plots.
Highly correlated genes for CST3:
Showing top 20/939 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CST3 | CLEC3B | 0.792536 | 3 | 0 | 3 |
| CST3 | CYP21A2 | 0.749357 | 3 | 0 | 3 |
| CST3 | SORCS1 | 0.732397 | 4 | 0 | 4 |
| CST3 | TUB | 0.726457 | 3 | 0 | 3 |
| CST3 | USP33 | 0.71953 | 3 | 0 | 3 |
| CST3 | SH3D19 | 0.715423 | 5 | 0 | 5 |
| CST3 | UGP2 | 0.708367 | 4 | 0 | 4 |
| CST3 | ANGPTL1 | 0.708203 | 6 | 0 | 6 |
| CST3 | NKIRAS1 | 0.703909 | 3 | 0 | 3 |
| CST3 | BVES | 0.697379 | 3 | 0 | 3 |
| CST3 | ANKS1B | 0.696381 | 4 | 0 | 4 |
| CST3 | ESYT2 | 0.693202 | 3 | 0 | 3 |
| CST3 | ARL1 | 0.691924 | 6 | 0 | 5 |
| CST3 | AFF3 | 0.689327 | 3 | 0 | 3 |
| CST3 | SLMAP | 0.688081 | 5 | 0 | 3 |
| CST3 | ADD1 | 0.686201 | 9 | 0 | 8 |
| CST3 | PGRMC2 | 0.682974 | 7 | 0 | 7 |
| CST3 | IL6ST | 0.679483 | 8 | 0 | 7 |
| CST3 | CCDC69 | 0.672314 | 8 | 0 | 7 |
| CST3 | PPP2R5C | 0.67051 | 4 | 0 | 3 |
For details and further investigation, click here
