| Full name: ADP ribosylation factor like GTPase 1 | Alias Symbol: ARFL1 | ||
| Type: protein-coding gene | Cytoband: 12q23.2 | ||
| Entrez ID: 400 | HGNC ID: HGNC:692 | Ensembl Gene: ENSG00000120805 | OMIM ID: 603425 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of ARL1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ARL1 | 400 | 201658_at | -0.5855 | 0.1511 | |
| GSE20347 | ARL1 | 400 | 201658_at | -0.7429 | 0.0000 | |
| GSE23400 | ARL1 | 400 | 201658_at | -0.4633 | 0.0000 | |
| GSE26886 | ARL1 | 400 | 201658_at | -0.7182 | 0.0005 | |
| GSE29001 | ARL1 | 400 | 201658_at | -0.4062 | 0.0186 | |
| GSE38129 | ARL1 | 400 | 201658_at | -0.7329 | 0.0000 | |
| GSE45670 | ARL1 | 400 | 201659_s_at | -0.2000 | 0.1746 | |
| GSE53622 | ARL1 | 400 | 9097 | -0.8265 | 0.0000 | |
| GSE53624 | ARL1 | 400 | 9097 | -0.6723 | 0.0000 | |
| GSE63941 | ARL1 | 400 | 201659_s_at | -0.1794 | 0.5144 | |
| GSE77861 | ARL1 | 400 | 201659_s_at | -0.5391 | 0.0114 | |
| GSE97050 | ARL1 | 400 | A_24_P338648 | -0.8813 | 0.0620 | |
| SRP007169 | ARL1 | 400 | RNAseq | -1.0871 | 0.0010 | |
| SRP008496 | ARL1 | 400 | RNAseq | -0.8096 | 0.0000 | |
| SRP064894 | ARL1 | 400 | RNAseq | -0.5220 | 0.0000 | |
| SRP133303 | ARL1 | 400 | RNAseq | -0.1238 | 0.3066 | |
| SRP159526 | ARL1 | 400 | RNAseq | -0.4763 | 0.0348 | |
| SRP193095 | ARL1 | 400 | RNAseq | -0.7387 | 0.0000 | |
| SRP219564 | ARL1 | 400 | RNAseq | -0.5215 | 0.0720 | |
| TCGA | ARL1 | 400 | RNAseq | -0.1763 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by ARL1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ARL1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ARL1 | 400 | 2 | 2 | 26 | |
| GSE20123 | ARL1 | 400 | 2 | 2 | 26 | |
| GSE43470 | ARL1 | 400 | 2 | 0 | 41 | |
| GSE46452 | ARL1 | 400 | 9 | 1 | 49 | |
| GSE47630 | ARL1 | 400 | 9 | 1 | 30 | |
| GSE54993 | ARL1 | 400 | 0 | 5 | 65 | |
| GSE54994 | ARL1 | 400 | 4 | 2 | 47 | |
| GSE60625 | ARL1 | 400 | 0 | 0 | 11 | |
| GSE74703 | ARL1 | 400 | 2 | 0 | 34 | |
| GSE74704 | ARL1 | 400 | 1 | 2 | 17 | |
| TCGA | ARL1 | 400 | 19 | 10 | 67 |
Total number of gains: 50; Total number of losses: 25; Total Number of normals: 413.
Somatic mutations of ARL1:
Generating mutation plots.
Highly correlated genes for ARL1:
Showing top 20/1582 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ARL1 | ANGPTL1 | 0.815512 | 4 | 0 | 4 |
| ARL1 | AKIRIN1 | 0.808176 | 3 | 0 | 3 |
| ARL1 | CLEC3B | 0.786441 | 3 | 0 | 3 |
| ARL1 | EXD3 | 0.777766 | 3 | 0 | 3 |
| ARL1 | HLF | 0.768959 | 10 | 0 | 10 |
| ARL1 | EEPD1 | 0.766907 | 3 | 0 | 3 |
| ARL1 | CYP21A2 | 0.753246 | 3 | 0 | 3 |
| ARL1 | UBE3A | 0.748354 | 3 | 0 | 3 |
| ARL1 | CGNL1 | 0.746488 | 7 | 0 | 7 |
| ARL1 | BLOC1S2 | 0.736658 | 3 | 0 | 3 |
| ARL1 | PLCXD3 | 0.730619 | 3 | 0 | 3 |
| ARL1 | RERG | 0.729571 | 4 | 0 | 4 |
| ARL1 | SORBS1 | 0.72696 | 5 | 0 | 4 |
| ARL1 | PDK2 | 0.724755 | 3 | 0 | 3 |
| ARL1 | NR2F1 | 0.724725 | 3 | 0 | 3 |
| ARL1 | HPGD | 0.724628 | 11 | 0 | 11 |
| ARL1 | SHROOM3 | 0.722515 | 7 | 0 | 6 |
| ARL1 | C1QTNF7 | 0.719289 | 5 | 0 | 4 |
| ARL1 | TGFBR3 | 0.718337 | 8 | 0 | 8 |
| ARL1 | CTTNBP2 | 0.717995 | 6 | 0 | 6 |
For details and further investigation, click here
