TMCO1

 

Full name: transmembrane and coiled-coil domains 1 Alias Symbol: HP10122
Type: protein-coding gene Cytoband: 1q24.1
Entrez ID: 54499 HGNC ID: HGNC:18188 Ensembl Gene: ENSG00000143183 OMIM ID: 614123
Drug and gene relationship at DGIdb

 

Expression of TMCO1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 TMCO1 54499 208716_s_at 0.2512 0.4399
GSE20347 TMCO1 54499 208716_s_at -0.0206 0.9489
GSE23400 TMCO1 54499 208716_s_at 0.2307 0.0004
GSE26886 TMCO1 54499 208716_s_at -0.1952 0.2941
GSE29001 TMCO1 54499 208716_s_at 0.0997 0.7600
GSE38129 TMCO1 54499 208716_s_at 0.3478 0.0730
GSE45670 TMCO1 54499 208716_s_at 0.3898 0.0003
GSE53622 TMCO1 54499 2849 0.2830 0.0000
GSE53624 TMCO1 54499 2849 0.3697 0.0000
GSE63941 TMCO1 54499 208716_s_at -0.3231 0.3237
GSE77861 TMCO1 54499 208716_s_at 0.1294 0.5101
GSE97050 TMCO1 54499 A_23_P355067 0.5220 0.1239
SRP007169 TMCO1 54499 RNAseq -0.8683 0.0186
SRP008496 TMCO1 54499 RNAseq -0.4545 0.0591
SRP064894 TMCO1 54499 RNAseq 0.0786 0.5867
SRP133303 TMCO1 54499 RNAseq 0.2443 0.0907
SRP159526 TMCO1 54499 RNAseq 0.3555 0.1196
SRP193095 TMCO1 54499 RNAseq -0.2529 0.0534
SRP219564 TMCO1 54499 RNAseq 0.4451 0.2065
TCGA TMCO1 54499 RNAseq 0.0635 0.1916

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by TMCO1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of TMCO1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 TMCO1 54499 10 2 18
GSE20123 TMCO1 54499 10 2 18
GSE43470 TMCO1 54499 7 2 34
GSE46452 TMCO1 54499 2 1 56
GSE47630 TMCO1 54499 14 0 26
GSE54993 TMCO1 54499 0 5 65
GSE54994 TMCO1 54499 16 0 37
GSE60625 TMCO1 54499 0 0 11
GSE74703 TMCO1 54499 7 2 27
GSE74704 TMCO1 54499 4 1 15
TCGA TMCO1 54499 44 3 49

Total number of gains: 114; Total number of losses: 18; Total Number of normals: 356.  

 

Somatic mutations of TMCO1:

 

Generating mutation plots.

 

Highly correlated genes for TMCO1:

 

Showing top 20/424 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
TMCO1EAPP0.716887303
TMCO1BZW10.676075503
TMCO1SLC31A10.669826504
TMCO1LRIG30.667696303
TMCO1USP380.663619303
TMCO1STEAP1B0.660989404
TMCO1CCT6A0.657192403
TMCO1TMEM179B0.653841303
TMCO1UBR50.648206403
TMCO1FAM83A0.646081303
TMCO1ZNF3170.644597303
TMCO1EIF3H0.638145404
TMCO1VAV10.637115303
TMCO1PDSS20.636224404
TMCO1ZBTB90.635774404
TMCO1TPM30.630209605
TMCO1CDK5R10.628956303
TMCO1TTC39C0.62131404
TMCO1RAD170.61576403
TMCO1ATF60.615674303

For details and further investigation, click here