| Full name: cytochrome P450 family 7 subfamily A member 1 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 8q12.1 | ||
| Entrez ID: 1581 | HGNC ID: HGNC:2651 | Ensembl Gene: ENSG00000167910 | OMIM ID: 118455 |
| Drug and gene relationship at DGIdb | |||
CYP7A1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa03320 | PPAR signaling pathway | |
| hsa04976 | Bile secretion |
Expression of CYP7A1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CYP7A1 | 1581 | 207406_at | 0.1558 | 0.4368 | |
| GSE20347 | CYP7A1 | 1581 | 207406_at | 0.0074 | 0.8812 | |
| GSE23400 | CYP7A1 | 1581 | 207406_at | 0.0081 | 0.6427 | |
| GSE26886 | CYP7A1 | 1581 | 207406_at | 0.0349 | 0.6752 | |
| GSE29001 | CYP7A1 | 1581 | 207406_at | 0.0482 | 0.7743 | |
| GSE38129 | CYP7A1 | 1581 | 207406_at | -0.0348 | 0.4404 | |
| GSE45670 | CYP7A1 | 1581 | 207406_at | 0.0392 | 0.5357 | |
| GSE53622 | CYP7A1 | 1581 | 21362 | 0.1221 | 0.2499 | |
| GSE53624 | CYP7A1 | 1581 | 21362 | -0.0172 | 0.8500 | |
| GSE63941 | CYP7A1 | 1581 | 207406_at | -0.1138 | 0.3449 | |
| GSE77861 | CYP7A1 | 1581 | 207406_at | 0.0258 | 0.7008 | |
| TCGA | CYP7A1 | 1581 | RNAseq | -0.1208 | 0.9012 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by CYP7A1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CYP7A1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CYP7A1 | 1581 | 13 | 1 | 16 | |
| GSE20123 | CYP7A1 | 1581 | 13 | 1 | 16 | |
| GSE43470 | CYP7A1 | 1581 | 14 | 3 | 26 | |
| GSE46452 | CYP7A1 | 1581 | 20 | 3 | 36 | |
| GSE47630 | CYP7A1 | 1581 | 23 | 1 | 16 | |
| GSE54993 | CYP7A1 | 1581 | 1 | 17 | 52 | |
| GSE54994 | CYP7A1 | 1581 | 30 | 0 | 23 | |
| GSE60625 | CYP7A1 | 1581 | 0 | 4 | 7 | |
| GSE74703 | CYP7A1 | 1581 | 12 | 2 | 22 | |
| GSE74704 | CYP7A1 | 1581 | 9 | 0 | 11 | |
| TCGA | CYP7A1 | 1581 | 44 | 6 | 46 |
Total number of gains: 179; Total number of losses: 38; Total Number of normals: 271.
Somatic mutations of CYP7A1:
Generating mutation plots.
Highly correlated genes for CYP7A1:
Showing top 20/30 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CYP7A1 | SLC6A6 | 0.704393 | 3 | 0 | 3 |
| CYP7A1 | CD80 | 0.670882 | 3 | 0 | 3 |
| CYP7A1 | SPO11 | 0.665333 | 3 | 0 | 3 |
| CYP7A1 | FPR2 | 0.652673 | 3 | 0 | 3 |
| CYP7A1 | KERA | 0.645615 | 3 | 0 | 3 |
| CYP7A1 | CDH10 | 0.641382 | 3 | 0 | 3 |
| CYP7A1 | SPTA1 | 0.616622 | 4 | 0 | 3 |
| CYP7A1 | SLC22A2 | 0.605441 | 3 | 0 | 3 |
| CYP7A1 | PDE6C | 0.59832 | 5 | 0 | 5 |
| CYP7A1 | SLC5A4 | 0.596286 | 4 | 0 | 4 |
| CYP7A1 | BMP15 | 0.593338 | 3 | 0 | 3 |
| CYP7A1 | AOC2 | 0.592722 | 5 | 0 | 3 |
| CYP7A1 | C6 | 0.587906 | 3 | 0 | 3 |
| CYP7A1 | KRTAP9-9 | 0.581107 | 4 | 0 | 4 |
| CYP7A1 | IFNB1 | 0.576307 | 3 | 0 | 3 |
| CYP7A1 | SLC23A2 | 0.571741 | 3 | 0 | 3 |
| CYP7A1 | GYPA | 0.570808 | 4 | 0 | 3 |
| CYP7A1 | LMAN1 | 0.569133 | 5 | 0 | 3 |
| CYP7A1 | FABP7 | 0.561307 | 5 | 0 | 3 |
| CYP7A1 | KCNN1 | 0.557666 | 3 | 0 | 3 |
For details and further investigation, click here
