TMEM177

 

Full name: transmembrane protein 177 Alias Symbol: MGC10993
Type: protein-coding gene Cytoband: 2q14.2
Entrez ID: 80775 HGNC ID: HGNC:28143 Ensembl Gene: ENSG00000144120 OMIM ID: 
Drug and gene relationship at DGIdb

 

Expression of TMEM177:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 TMEM177 80775 218897_at 1.5626 0.0126
GSE20347 TMEM177 80775 218897_at 0.7831 0.0000
GSE23400 TMEM177 80775 218897_at 0.4130 0.0000
GSE26886 TMEM177 80775 218897_at 1.4178 0.0001
GSE29001 TMEM177 80775 218897_at 0.7179 0.0113
GSE38129 TMEM177 80775 218897_at 1.1262 0.0000
GSE45670 TMEM177 80775 218897_at 0.9652 0.0000
GSE53622 TMEM177 80775 164766 0.8476 0.0000
GSE53624 TMEM177 80775 164766 1.1407 0.0000
GSE63941 TMEM177 80775 218897_at 1.2012 0.0169
GSE77861 TMEM177 80775 237506_at -0.0982 0.5157
GSE97050 TMEM177 80775 A_23_P5339 0.5120 0.1344
SRP007169 TMEM177 80775 RNAseq 0.9035 0.0637
SRP008496 TMEM177 80775 RNAseq 1.3091 0.0003
SRP064894 TMEM177 80775 RNAseq 0.5519 0.0334
SRP133303 TMEM177 80775 RNAseq 0.3398 0.0834
SRP159526 TMEM177 80775 RNAseq 0.9789 0.0000
SRP193095 TMEM177 80775 RNAseq 0.4326 0.0033
SRP219564 TMEM177 80775 RNAseq 0.4411 0.2163
TCGA TMEM177 80775 RNAseq 0.3792 0.0000

Upregulated datasets: 6; Downregulated datasets: 0.  

 

Survival by TMEM177 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of TMEM177:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 TMEM177 80775 6 2 22
GSE20123 TMEM177 80775 6 2 22
GSE43470 TMEM177 80775 3 1 39
GSE46452 TMEM177 80775 1 4 54
GSE47630 TMEM177 80775 6 0 34
GSE54993 TMEM177 80775 0 6 64
GSE54994 TMEM177 80775 12 0 41
GSE60625 TMEM177 80775 0 3 8
GSE74703 TMEM177 80775 3 1 32
GSE74704 TMEM177 80775 3 1 16
TCGA TMEM177 80775 32 6 58

Total number of gains: 72; Total number of losses: 26; Total Number of normals: 390.  

 

Somatic mutations of TMEM177:

 

Generating mutation plots.

 

Highly correlated genes for TMEM177:

 

Showing top 20/1117 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
TMEM177DNAJB110.745081505
TMEM177MYBL20.7314811011
TMEM177TOP1MT0.730094606
TMEM177RUVBL10.73006911010
TMEM177TMEM185B0.7272112012
TMEM177ACLY0.72297710010
TMEM177MTBP0.714214606
TMEM177CTU20.714033606
TMEM177NUDT10.70951811011
TMEM177C8orf820.708842303
TMEM177CCT30.70859811010
TMEM177MRPL470.704467606
TMEM177MTHFD1L0.704087303
TMEM177ERCC6L0.703537909
TMEM177SLC45A40.700212505
TMEM177GFM10.700116605
TMEM177SHISA20.698797404
TMEM177SIX40.69784706
TMEM177DOCK60.697173303
TMEM177B3GALT60.695121605

For details and further investigation, click here