DBR1

 

Full name: debranching RNA lariats 1 Alias Symbol: 
Type: protein-coding gene Cytoband: 3q22.3
Entrez ID: 51163 HGNC ID: HGNC:15594 Ensembl Gene: ENSG00000138231 OMIM ID: 607024
Drug and gene relationship at DGIdb

 

Expression of DBR1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 DBR1 51163 234295_at 1.1313 0.0346
GSE20347 DBR1 51163 219149_x_at 0.3872 0.0000
GSE23400 DBR1 51163 219149_x_at 0.3433 0.0000
GSE26886 DBR1 51163 234295_at 0.6703 0.0099
GSE29001 DBR1 51163 219149_x_at 0.2746 0.1875
GSE38129 DBR1 51163 219149_x_at 0.5259 0.0000
GSE45670 DBR1 51163 219149_x_at 0.4938 0.0000
GSE63941 DBR1 51163 234295_at 0.3733 0.3471
GSE77861 DBR1 51163 234295_at 0.9677 0.0118
GSE97050 DBR1 51163 A_23_P69452 0.1716 0.5102
SRP007169 DBR1 51163 RNAseq 1.7183 0.0010
SRP008496 DBR1 51163 RNAseq 1.4818 0.0000
SRP064894 DBR1 51163 RNAseq 0.7265 0.0009
SRP133303 DBR1 51163 RNAseq 0.8074 0.0000
SRP159526 DBR1 51163 RNAseq 0.9506 0.0027
SRP193095 DBR1 51163 RNAseq 0.5871 0.0000
SRP219564 DBR1 51163 RNAseq 0.5416 0.0498
TCGA DBR1 51163 RNAseq 0.1843 0.0018

Upregulated datasets: 3; Downregulated datasets: 0.  

 

Survival by DBR1 expression:

 

TCGA

 

Note: Click image to view full size file.  

Copy number change of DBR1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 DBR1 51163 17 0 13
GSE20123 DBR1 51163 17 0 13
GSE43470 DBR1 51163 21 0 22
GSE46452 DBR1 51163 15 4 40
GSE47630 DBR1 51163 18 3 19
GSE54993 DBR1 51163 2 8 60
GSE54994 DBR1 51163 31 2 20
GSE60625 DBR1 51163 0 6 5
GSE74703 DBR1 51163 18 0 18
GSE74704 DBR1 51163 11 0 9
TCGA DBR1 51163 61 4 31

Total number of gains: 211; Total number of losses: 27; Total Number of normals: 250.  

 

Somatic mutations of DBR1:

 

Generating mutation plots.

 

Highly correlated genes for DBR1:

 

Showing top 20/1230 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
DBR1DNAJB110.731244404
DBR1PNPT10.720093404
DBR1NUF20.704297505
DBR1LINC011160.701827303
DBR1TDRD50.696172303
DBR1PRPF40A0.695223504
DBR1BPNT10.69144303
DBR1ZFP410.688207303
DBR1MRPL470.686927505
DBR1ITGA60.686459808
DBR1ZFHX30.685654303
DBR1PIGX0.682031404
DBR1TBC1D320.681218303
DBR1TOPBP10.68109611011
DBR1BEND30.680034404
DBR1NEDD10.679366505
DBR1AP3D10.679286303
DBR1BUB10.678603706
DBR1ACBD60.67621403
DBR1GFM10.676205605

For details and further investigation, click here