| Full name: ER membrane protein complex subunit 1 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 1p36.13 | ||
| Entrez ID: 23065 | HGNC ID: HGNC:28957 | Ensembl Gene: ENSG00000127463 | OMIM ID: 616846 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of EMC1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | EMC1 | 23065 | 212396_s_at | 1.0624 | 0.0070 | |
| GSE20347 | EMC1 | 23065 | 212396_s_at | 0.8004 | 0.0000 | |
| GSE23400 | EMC1 | 23065 | 212396_s_at | 0.7332 | 0.0000 | |
| GSE26886 | EMC1 | 23065 | 212395_s_at | 0.1355 | 0.5847 | |
| GSE29001 | EMC1 | 23065 | 212395_s_at | 0.3359 | 0.0663 | |
| GSE38129 | EMC1 | 23065 | 212396_s_at | 0.9459 | 0.0000 | |
| GSE45670 | EMC1 | 23065 | 1556186_s_at | 0.4353 | 0.0109 | |
| GSE53622 | EMC1 | 23065 | 101770 | 0.6773 | 0.0000 | |
| GSE53624 | EMC1 | 23065 | 101770 | 0.9547 | 0.0000 | |
| GSE63941 | EMC1 | 23065 | 212396_s_at | -0.2760 | 0.4870 | |
| GSE77861 | EMC1 | 23065 | 212396_s_at | 0.3234 | 0.2662 | |
| SRP007169 | EMC1 | 23065 | RNAseq | 1.3183 | 0.0093 | |
| SRP008496 | EMC1 | 23065 | RNAseq | 1.3436 | 0.0001 | |
| SRP064894 | EMC1 | 23065 | RNAseq | 0.9307 | 0.0000 | |
| SRP133303 | EMC1 | 23065 | RNAseq | 0.5594 | 0.0000 | |
| SRP159526 | EMC1 | 23065 | RNAseq | 0.9415 | 0.0080 | |
| SRP193095 | EMC1 | 23065 | RNAseq | 0.4990 | 0.0000 | |
| SRP219564 | EMC1 | 23065 | RNAseq | 0.5609 | 0.0194 |
Upregulated datasets: 3; Downregulated datasets: 0.
Survival by EMC1 expression:
 |  |
| GSE53622 | GSE53624 |
Note: Click image to view full size file.
Copy number change of EMC1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | EMC1 | 23065 | 0 | 5 | 25 | |
| GSE20123 | EMC1 | 23065 | 0 | 4 | 26 | |
| GSE43470 | EMC1 | 23065 | 0 | 8 | 35 | |
| GSE46452 | EMC1 | 23065 | 5 | 1 | 53 | |
| GSE47630 | EMC1 | 23065 | 8 | 3 | 29 | |
| GSE54993 | EMC1 | 23065 | 3 | 1 | 66 | |
| GSE54994 | EMC1 | 23065 | 11 | 4 | 38 | |
| GSE60625 | EMC1 | 23065 | 0 | 0 | 11 | |
| GSE74703 | EMC1 | 23065 | 0 | 5 | 31 | |
| GSE74704 | EMC1 | 23065 | 0 | 0 | 20 | |
| TCGA | EMC1 | 23065 | 10 | 22 | 64 |
Total number of gains: 37; Total number of losses: 53; Total Number of normals: 398.
Somatic mutations of EMC1:
Generating mutation plots.
Highly correlated genes for EMC1:
Showing top 20/1392 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| EMC1 | MAD2L2 | 0.764332 | 5 | 0 | 5 |
| EMC1 | UBE2T | 0.740035 | 4 | 0 | 4 |
| EMC1 | DDOST | 0.737032 | 10 | 0 | 10 |
| EMC1 | SNRPC | 0.73548 | 6 | 0 | 6 |
| EMC1 | RPGRIP1L | 0.735125 | 3 | 0 | 3 |
| EMC1 | PLOD1 | 0.730623 | 10 | 0 | 10 |
| EMC1 | SLC39A10 | 0.723926 | 4 | 0 | 3 |
| EMC1 | MCM6 | 0.72361 | 7 | 0 | 7 |
| EMC1 | SIX4 | 0.718837 | 4 | 0 | 4 |
| EMC1 | CTU2 | 0.711682 | 3 | 0 | 3 |
| EMC1 | PTK7 | 0.708176 | 9 | 0 | 8 |
| EMC1 | UBE2S | 0.705745 | 5 | 0 | 5 |
| EMC1 | LAMB3 | 0.704405 | 9 | 0 | 9 |
| EMC1 | RIOK1 | 0.703615 | 3 | 0 | 3 |
| EMC1 | DNMT1 | 0.70168 | 8 | 0 | 8 |
| EMC1 | MAD2L1 | 0.700102 | 8 | 0 | 7 |
| EMC1 | MRGBP | 0.697849 | 8 | 0 | 7 |
| EMC1 | ZNF697 | 0.697485 | 3 | 0 | 3 |
| EMC1 | EFTUD2 | 0.694586 | 4 | 0 | 4 |
| EMC1 | CCDC34 | 0.694583 | 3 | 0 | 3 |
For details and further investigation, click here
