| Full name: DEAD-box helicase 6 | Alias Symbol: RCK | ||
| Type: protein-coding gene | Cytoband: 11q23.3 | ||
| Entrez ID: 1656 | HGNC ID: HGNC:2747 | Ensembl Gene: ENSG00000110367 | OMIM ID: 600326 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of DDX6:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DDX6 | 1656 | 225549_at | 0.0710 | 0.8819 | |
| GSE20347 | DDX6 | 1656 | 204909_at | 0.0097 | 0.9326 | |
| GSE23400 | DDX6 | 1656 | 204909_at | 0.0066 | 0.8644 | |
| GSE26886 | DDX6 | 1656 | 225549_at | 0.0749 | 0.7911 | |
| GSE29001 | DDX6 | 1656 | 204909_at | -0.1588 | 0.5135 | |
| GSE38129 | DDX6 | 1656 | 204909_at | -0.0031 | 0.9851 | |
| GSE45670 | DDX6 | 1656 | 225549_at | -0.0539 | 0.6823 | |
| GSE53622 | DDX6 | 1656 | 27082 | -0.3896 | 0.0000 | |
| GSE53624 | DDX6 | 1656 | 27082 | -0.3367 | 0.0000 | |
| GSE63941 | DDX6 | 1656 | 225549_at | -0.9357 | 0.1642 | |
| GSE77861 | DDX6 | 1656 | 225549_at | 0.2974 | 0.5211 | |
| GSE97050 | DDX6 | 1656 | A_24_P215407 | -0.2730 | 0.3112 | |
| SRP007169 | DDX6 | 1656 | RNAseq | -0.2759 | 0.3567 | |
| SRP008496 | DDX6 | 1656 | RNAseq | -0.0331 | 0.8245 | |
| SRP064894 | DDX6 | 1656 | RNAseq | -0.7053 | 0.0000 | |
| SRP133303 | DDX6 | 1656 | RNAseq | -0.1317 | 0.1522 | |
| SRP159526 | DDX6 | 1656 | RNAseq | -0.3831 | 0.0676 | |
| SRP193095 | DDX6 | 1656 | RNAseq | -0.5508 | 0.0000 | |
| SRP219564 | DDX6 | 1656 | RNAseq | -0.5359 | 0.0909 | |
| TCGA | DDX6 | 1656 | RNAseq | -0.0834 | 0.0434 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by DDX6 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DDX6:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DDX6 | 1656 | 2 | 11 | 17 | |
| GSE20123 | DDX6 | 1656 | 2 | 11 | 17 | |
| GSE43470 | DDX6 | 1656 | 2 | 9 | 32 | |
| GSE46452 | DDX6 | 1656 | 3 | 26 | 30 | |
| GSE47630 | DDX6 | 1656 | 2 | 19 | 19 | |
| GSE54993 | DDX6 | 1656 | 10 | 0 | 60 | |
| GSE54994 | DDX6 | 1656 | 5 | 19 | 29 | |
| GSE60625 | DDX6 | 1656 | 0 | 3 | 8 | |
| GSE74703 | DDX6 | 1656 | 1 | 6 | 29 | |
| GSE74704 | DDX6 | 1656 | 1 | 7 | 12 | |
| TCGA | DDX6 | 1656 | 4 | 51 | 41 |
Total number of gains: 32; Total number of losses: 162; Total Number of normals: 294.
Somatic mutations of DDX6:
Generating mutation plots.
Highly correlated genes for DDX6:
Showing top 20/158 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DDX6 | EVI5L | 0.779441 | 3 | 0 | 3 |
| DDX6 | HNRNPAB | 0.778239 | 3 | 0 | 3 |
| DDX6 | DCAF16 | 0.746205 | 3 | 0 | 3 |
| DDX6 | SUGP1 | 0.74307 | 3 | 0 | 3 |
| DDX6 | TJP1 | 0.740702 | 3 | 0 | 3 |
| DDX6 | WIZ | 0.7397 | 3 | 0 | 3 |
| DDX6 | LARP1 | 0.739087 | 3 | 0 | 3 |
| DDX6 | ZNF518A | 0.731839 | 3 | 0 | 3 |
| DDX6 | GYS1 | 0.724969 | 3 | 0 | 3 |
| DDX6 | HGS | 0.722984 | 3 | 0 | 3 |
| DDX6 | ELFN1 | 0.719805 | 3 | 0 | 3 |
| DDX6 | ZNF121 | 0.71875 | 3 | 0 | 3 |
| DDX6 | RUFY3 | 0.716994 | 3 | 0 | 3 |
| DDX6 | SUGP2 | 0.715738 | 3 | 0 | 3 |
| DDX6 | PRR12 | 0.714182 | 3 | 0 | 3 |
| DDX6 | ERGIC1 | 0.709904 | 3 | 0 | 3 |
| DDX6 | RFX1 | 0.709536 | 3 | 0 | 3 |
| DDX6 | DAZAP1 | 0.696008 | 3 | 0 | 3 |
| DDX6 | CBFA2T2 | 0.694367 | 3 | 0 | 3 |
| DDX6 | DSTYK | 0.69172 | 4 | 0 | 3 |
For details and further investigation, click here
