| Full name: diacylglycerol kinase iota | Alias Symbol: DGK-IOTA | ||
| Type: protein-coding gene | Cytoband: 7q33 | ||
| Entrez ID: 9162 | HGNC ID: HGNC:2855 | Ensembl Gene: ENSG00000157680 | OMIM ID: 604072 |
| Drug and gene relationship at DGIdb | |||
Expression of DGKI:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DGKI | 9162 | 206806_at | -0.1407 | 0.6623 | |
| GSE20347 | DGKI | 9162 | 206806_at | 0.1462 | 0.1163 | |
| GSE23400 | DGKI | 9162 | 206806_at | 0.0416 | 0.2911 | |
| GSE26886 | DGKI | 9162 | 206806_at | 0.3204 | 0.0807 | |
| GSE29001 | DGKI | 9162 | 206806_at | 0.2683 | 0.2726 | |
| GSE38129 | DGKI | 9162 | 206806_at | 0.1026 | 0.0789 | |
| GSE45670 | DGKI | 9162 | 206806_at | 0.2718 | 0.0277 | |
| GSE53622 | DGKI | 9162 | 30970 | 1.5828 | 0.0000 | |
| GSE53624 | DGKI | 9162 | 30970 | 1.1408 | 0.0000 | |
| GSE63941 | DGKI | 9162 | 206806_at | -2.6359 | 0.0000 | |
| GSE77861 | DGKI | 9162 | 206806_at | 0.0756 | 0.5623 | |
| SRP007169 | DGKI | 9162 | RNAseq | 5.4748 | 0.0001 | |
| SRP133303 | DGKI | 9162 | RNAseq | 2.4657 | 0.0000 | |
| SRP159526 | DGKI | 9162 | RNAseq | 2.5338 | 0.0002 | |
| SRP193095 | DGKI | 9162 | RNAseq | 2.1631 | 0.0000 | |
| SRP219564 | DGKI | 9162 | RNAseq | 1.7134 | 0.0617 | |
| TCGA | DGKI | 9162 | RNAseq | 0.4016 | 0.3879 |
Upregulated datasets: 6; Downregulated datasets: 1.
Survival by DGKI expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DGKI:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DGKI | 9162 | 5 | 2 | 23 | |
| GSE20123 | DGKI | 9162 | 5 | 2 | 23 | |
| GSE43470 | DGKI | 9162 | 2 | 3 | 38 | |
| GSE46452 | DGKI | 9162 | 7 | 2 | 50 | |
| GSE47630 | DGKI | 9162 | 7 | 4 | 29 | |
| GSE54993 | DGKI | 9162 | 3 | 5 | 62 | |
| GSE54994 | DGKI | 9162 | 6 | 8 | 39 | |
| GSE60625 | DGKI | 9162 | 0 | 0 | 11 | |
| GSE74703 | DGKI | 9162 | 2 | 3 | 31 | |
| GSE74704 | DGKI | 9162 | 2 | 2 | 16 | |
| TCGA | DGKI | 9162 | 28 | 23 | 45 |
Total number of gains: 67; Total number of losses: 54; Total Number of normals: 367.
Somatic mutations of DGKI:
Generating mutation plots.
Highly correlated genes for DGKI:
Showing top 20/145 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DGKI | NR4A3 | 0.764711 | 3 | 0 | 3 |
| DGKI | DDR2 | 0.740816 | 3 | 0 | 3 |
| DGKI | CALU | 0.702223 | 4 | 0 | 4 |
| DGKI | WDR63 | 0.70055 | 3 | 0 | 3 |
| DGKI | C11orf96 | 0.699467 | 3 | 0 | 3 |
| DGKI | NOX4 | 0.68506 | 4 | 0 | 4 |
| DGKI | DIXDC1 | 0.680496 | 3 | 0 | 3 |
| DGKI | TMEM170B | 0.669207 | 3 | 0 | 3 |
| DGKI | ARMC9 | 0.666654 | 3 | 0 | 3 |
| DGKI | SCG5 | 0.665305 | 4 | 0 | 4 |
| DGKI | SYPL2 | 0.662144 | 3 | 0 | 3 |
| DGKI | HABP4 | 0.661182 | 3 | 0 | 3 |
| DGKI | POSTN | 0.659908 | 4 | 0 | 4 |
| DGKI | PMP22 | 0.656179 | 3 | 0 | 3 |
| DGKI | CHN1 | 0.651714 | 4 | 0 | 4 |
| DGKI | PXDN | 0.650773 | 4 | 0 | 4 |
| DGKI | FNIP2 | 0.644135 | 3 | 0 | 3 |
| DGKI | GRIK2 | 0.644067 | 4 | 0 | 3 |
| DGKI | CDH11 | 0.643277 | 5 | 0 | 4 |
| DGKI | PCOLCE | 0.643083 | 4 | 0 | 4 |
For details and further investigation, click here
