| Full name: DExH-box helicase 58 | Alias Symbol: LGP2|D11LGP2 | ||
| Type: protein-coding gene | Cytoband: 17q21.2 | ||
| Entrez ID: 79132 | HGNC ID: HGNC:29517 | Ensembl Gene: ENSG00000108771 | OMIM ID: 608588 |
| Drug and gene relationship at DGIdb | |||
DHX58 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04622 | RIG-I-like receptor signaling pathway |
Expression of DHX58:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DHX58 | 79132 | 219364_at | 0.0890 | 0.8089 | |
| GSE20347 | DHX58 | 79132 | 219364_at | 0.0821 | 0.4504 | |
| GSE23400 | DHX58 | 79132 | 219364_at | -0.0020 | 0.9662 | |
| GSE26886 | DHX58 | 79132 | 219364_at | 0.6825 | 0.0016 | |
| GSE29001 | DHX58 | 79132 | 219364_at | 0.3660 | 0.0081 | |
| GSE38129 | DHX58 | 79132 | 219364_at | 0.0791 | 0.4107 | |
| GSE45670 | DHX58 | 79132 | 219364_at | 0.4596 | 0.0133 | |
| GSE53622 | DHX58 | 79132 | 95510 | 0.3660 | 0.0057 | |
| GSE53624 | DHX58 | 79132 | 95510 | 0.5416 | 0.0000 | |
| GSE63941 | DHX58 | 79132 | 219364_at | -0.2063 | 0.7019 | |
| GSE77861 | DHX58 | 79132 | 219364_at | -0.0397 | 0.8666 | |
| GSE97050 | DHX58 | 79132 | A_23_P38346 | 0.2800 | 0.4848 | |
| SRP007169 | DHX58 | 79132 | RNAseq | 0.9764 | 0.1005 | |
| SRP008496 | DHX58 | 79132 | RNAseq | 0.9595 | 0.0315 | |
| SRP064894 | DHX58 | 79132 | RNAseq | 1.2485 | 0.0000 | |
| SRP133303 | DHX58 | 79132 | RNAseq | 0.5739 | 0.0178 | |
| SRP159526 | DHX58 | 79132 | RNAseq | -0.1986 | 0.6235 | |
| SRP193095 | DHX58 | 79132 | RNAseq | 0.6255 | 0.0001 | |
| SRP219564 | DHX58 | 79132 | RNAseq | 0.3154 | 0.4635 | |
| TCGA | DHX58 | 79132 | RNAseq | 0.0832 | 0.3894 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by DHX58 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DHX58:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DHX58 | 79132 | 6 | 2 | 22 | |
| GSE20123 | DHX58 | 79132 | 6 | 2 | 22 | |
| GSE43470 | DHX58 | 79132 | 1 | 2 | 40 | |
| GSE46452 | DHX58 | 79132 | 34 | 0 | 25 | |
| GSE47630 | DHX58 | 79132 | 8 | 1 | 31 | |
| GSE54993 | DHX58 | 79132 | 3 | 4 | 63 | |
| GSE54994 | DHX58 | 79132 | 8 | 5 | 40 | |
| GSE60625 | DHX58 | 79132 | 4 | 0 | 7 | |
| GSE74703 | DHX58 | 79132 | 1 | 1 | 34 | |
| GSE74704 | DHX58 | 79132 | 4 | 1 | 15 | |
| TCGA | DHX58 | 79132 | 23 | 6 | 67 |
Total number of gains: 98; Total number of losses: 24; Total Number of normals: 366.
Somatic mutations of DHX58:
Generating mutation plots.
Highly correlated genes for DHX58:
Showing top 20/529 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DHX58 | CMPK2 | 0.73527 | 7 | 0 | 6 |
| DHX58 | LSG1 | 0.731244 | 3 | 0 | 3 |
| DHX58 | GMPS | 0.729011 | 3 | 0 | 3 |
| DHX58 | DNAJC2 | 0.724357 | 3 | 0 | 3 |
| DHX58 | GDF9 | 0.710221 | 3 | 0 | 3 |
| DHX58 | FXR1 | 0.710042 | 3 | 0 | 3 |
| DHX58 | ADCY3 | 0.706728 | 3 | 0 | 3 |
| DHX58 | LRCH3 | 0.706441 | 3 | 0 | 3 |
| DHX58 | NLRC5 | 0.701808 | 4 | 0 | 4 |
| DHX58 | IFI35 | 0.701053 | 12 | 0 | 11 |
| DHX58 | SAFB2 | 0.696263 | 3 | 0 | 3 |
| DHX58 | LRRK1 | 0.692465 | 3 | 0 | 3 |
| DHX58 | IFI44L | 0.69046 | 12 | 0 | 11 |
| DHX58 | MEA1 | 0.688883 | 3 | 0 | 3 |
| DHX58 | PTPN1 | 0.68607 | 3 | 0 | 3 |
| DHX58 | C1orf35 | 0.683952 | 3 | 0 | 3 |
| DHX58 | ACTL6A | 0.682949 | 3 | 0 | 3 |
| DHX58 | USP41 | 0.68157 | 3 | 0 | 3 |
| DHX58 | EPSTI1 | 0.6799 | 7 | 0 | 6 |
| DHX58 | TLN2 | 0.678426 | 3 | 0 | 3 |
For details and further investigation, click here
