CDC20

 

Full name: cell division cycle 20 Alias Symbol: p55CDC|CDC20A
Type: protein-coding gene Cytoband: 1p34.2
Entrez ID: 991 HGNC ID: HGNC:1723 Ensembl Gene: ENSG00000117399 OMIM ID: 603618
Drug and gene relationship at DGIdb

 

CDC20 involved pathways:

KEGG pathway Description View
hsa04110Cell cycle
hsa04114Oocyte meiosis
hsa05166HTLV-I infection

 

Expression of CDC20:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 CDC20 991 202870_s_at 1.6375 0.0099
GSE20347 CDC20 991 202870_s_at 1.5895 0.0000
GSE23400 CDC20 991 202870_s_at 1.6981 0.0000
GSE26886 CDC20 991 202870_s_at 0.6002 0.1421
GSE29001 CDC20 991 202870_s_at 1.4336 0.0004
GSE38129 CDC20 991 202870_s_at 2.1633 0.0000
GSE45670 CDC20 991 202870_s_at 1.7302 0.0000
GSE53622 CDC20 991 48961 1.2870 0.0000
GSE53624 CDC20 991 48961 1.7273 0.0000
GSE63941 CDC20 991 202870_s_at 3.7929 0.0000
GSE77861 CDC20 991 202870_s_at 0.9426 0.0610
GSE97050 CDC20 991 A_23_P149200 1.0802 0.2204
SRP007169 CDC20 991 RNAseq 1.9237 0.0000
SRP008496 CDC20 991 RNAseq 1.1910 0.0003
SRP064894 CDC20 991 RNAseq 2.2555 0.0000
SRP133303 CDC20 991 RNAseq 1.9154 0.0000
SRP159526 CDC20 991 RNAseq 2.4478 0.0012
SRP193095 CDC20 991 RNAseq 1.3540 0.0000
SRP219564 CDC20 991 RNAseq 2.0302 0.0120
TCGA CDC20 991 RNAseq 1.3011 0.0000

Upregulated datasets: 17; Downregulated datasets: 0.  

 

Survival by CDC20 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of CDC20:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 CDC20 991 4 3 23
GSE20123 CDC20 991 4 2 24
GSE43470 CDC20 991 7 2 34
GSE46452 CDC20 991 3 1 55
GSE47630 CDC20 991 9 2 29
GSE54993 CDC20 991 0 2 68
GSE54994 CDC20 991 13 2 38
GSE60625 CDC20 991 0 0 11
GSE74703 CDC20 991 6 1 29
GSE74704 CDC20 991 2 0 18
TCGA CDC20 991 13 16 67

Total number of gains: 61; Total number of losses: 31; Total Number of normals: 396.  

 

Somatic mutations of CDC20:

 

Generating mutation plots.

 

Highly correlated genes for CDC20:

 

Showing top 20/1025 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
CDC20BUB1B0.87963410010
CDC20KIF4A0.87419812012
CDC20DLGAP50.86051413012
CDC20UBE2C0.85888812012
CDC20KIF2C0.85887513012
CDC20TPX20.84927912011
CDC20CDCA80.84831413013
CDC20CDKN30.84382712011
CDC20NCAPH0.841786909
CDC20KIF20A0.83997912012
CDC20MELK0.83778411011
CDC20NUF20.833252707
CDC20CEP550.83050112011
CDC20CENPN0.82950611011
CDC20RAD510.82716512012
CDC20GINS20.82308512012
CDC20CDC60.82175310010
CDC20HMMR0.82043412011
CDC20OIP50.818862909
CDC20NEK20.81818112011

For details and further investigation, click here