| Full name: DIRAS family GTPase 3 | Alias Symbol: NOEY2 | ||
| Type: protein-coding gene | Cytoband: 1p31.3 | ||
| Entrez ID: 9077 | HGNC ID: HGNC:687 | Ensembl Gene: ENSG00000162595 | OMIM ID: 605193 |
| Drug and gene relationship at DGIdb | |||
Expression of DIRAS3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DIRAS3 | 9077 | 215506_s_at | -0.9185 | 0.3736 | |
| GSE20347 | DIRAS3 | 9077 | 215506_s_at | 0.1273 | 0.6649 | |
| GSE23400 | DIRAS3 | 9077 | 215506_s_at | -0.2223 | 0.0000 | |
| GSE26886 | DIRAS3 | 9077 | 215506_s_at | 0.1906 | 0.5705 | |
| GSE29001 | DIRAS3 | 9077 | 215506_s_at | -0.1717 | 0.2747 | |
| GSE38129 | DIRAS3 | 9077 | 215506_s_at | -0.1821 | 0.5483 | |
| GSE45670 | DIRAS3 | 9077 | 215506_s_at | -1.4165 | 0.0000 | |
| GSE53622 | DIRAS3 | 9077 | 28783 | -1.2924 | 0.0000 | |
| GSE53624 | DIRAS3 | 9077 | 28783 | -0.9304 | 0.0000 | |
| GSE63941 | DIRAS3 | 9077 | 215506_s_at | -2.7822 | 0.0026 | |
| GSE77861 | DIRAS3 | 9077 | 215506_s_at | 0.4037 | 0.5428 | |
| SRP064894 | DIRAS3 | 9077 | RNAseq | 0.0089 | 0.9791 | |
| SRP133303 | DIRAS3 | 9077 | RNAseq | -0.1032 | 0.8243 | |
| SRP159526 | DIRAS3 | 9077 | RNAseq | -0.3921 | 0.5398 | |
| SRP219564 | DIRAS3 | 9077 | RNAseq | -0.0735 | 0.9107 | |
| TCGA | DIRAS3 | 9077 | RNAseq | -0.8770 | 0.0002 |
Upregulated datasets: 0; Downregulated datasets: 3.
Survival by DIRAS3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DIRAS3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DIRAS3 | 9077 | 1 | 6 | 23 | |
| GSE20123 | DIRAS3 | 9077 | 1 | 5 | 24 | |
| GSE43470 | DIRAS3 | 9077 | 4 | 2 | 37 | |
| GSE46452 | DIRAS3 | 9077 | 0 | 1 | 58 | |
| GSE47630 | DIRAS3 | 9077 | 7 | 6 | 27 | |
| GSE54993 | DIRAS3 | 9077 | 0 | 0 | 70 | |
| GSE54994 | DIRAS3 | 9077 | 6 | 4 | 43 | |
| GSE60625 | DIRAS3 | 9077 | 0 | 0 | 11 | |
| GSE74703 | DIRAS3 | 9077 | 3 | 2 | 31 | |
| GSE74704 | DIRAS3 | 9077 | 1 | 2 | 17 | |
| TCGA | DIRAS3 | 9077 | 8 | 22 | 66 |
Total number of gains: 31; Total number of losses: 50; Total Number of normals: 407.
Somatic mutations of DIRAS3:
Generating mutation plots.
Highly correlated genes for DIRAS3:
Showing top 20/455 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DIRAS3 | TRPV2 | 0.700437 | 4 | 0 | 3 |
| DIRAS3 | CNRIP1 | 0.697427 | 5 | 0 | 5 |
| DIRAS3 | MAGI2-AS3 | 0.693796 | 5 | 0 | 5 |
| DIRAS3 | EBF1 | 0.690303 | 5 | 0 | 5 |
| DIRAS3 | NPR2 | 0.684707 | 3 | 0 | 3 |
| DIRAS3 | TNFRSF19 | 0.675717 | 5 | 0 | 4 |
| DIRAS3 | CLIP3 | 0.675103 | 6 | 0 | 6 |
| DIRAS3 | ST6GALNAC3 | 0.663561 | 5 | 0 | 5 |
| DIRAS3 | NEXN | 0.661516 | 4 | 0 | 4 |
| DIRAS3 | RCAN2 | 0.656443 | 7 | 0 | 7 |
| DIRAS3 | HGF | 0.655225 | 3 | 0 | 3 |
| DIRAS3 | ATOH8 | 0.654784 | 4 | 0 | 3 |
| DIRAS3 | FAM162B | 0.650113 | 4 | 0 | 3 |
| DIRAS3 | CSGALNACT1 | 0.647675 | 7 | 0 | 6 |
| DIRAS3 | FBXL7 | 0.647286 | 7 | 0 | 6 |
| DIRAS3 | ELOVL5 | 0.646994 | 3 | 0 | 3 |
| DIRAS3 | CXCL5 | 0.64422 | 4 | 0 | 4 |
| DIRAS3 | GFRA1 | 0.642792 | 6 | 0 | 5 |
| DIRAS3 | ANK2 | 0.64182 | 5 | 0 | 4 |
| DIRAS3 | WFS1 | 0.639309 | 5 | 0 | 4 |
For details and further investigation, click here
