DPH2

 

Full name: diphthamide biosynthesis 2 Alias Symbol: 
Type: protein-coding gene Cytoband: 1p34.1
Entrez ID: 1802 HGNC ID: HGNC:3004 Ensembl Gene: ENSG00000132768 OMIM ID: 603456
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of DPH2:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 DPH2 1802 204514_at 0.8466 0.1750
GSE20347 DPH2 1802 204514_at 0.4272 0.0004
GSE23400 DPH2 1802 204514_at 0.2844 0.0000
GSE26886 DPH2 1802 204514_at 0.1955 0.3339
GSE29001 DPH2 1802 204514_at 0.2987 0.0290
GSE38129 DPH2 1802 204514_at 0.4547 0.0000
GSE45670 DPH2 1802 204514_at 0.4457 0.0004
GSE53622 DPH2 1802 118556 0.4169 0.0000
GSE53624 DPH2 1802 118556 0.8435 0.0000
GSE63941 DPH2 1802 204514_at 0.6948 0.1401
GSE77861 DPH2 1802 204514_at 0.1662 0.2524
GSE97050 DPH2 1802 A_24_P393844 0.1822 0.5507
SRP007169 DPH2 1802 RNAseq 1.0771 0.0103
SRP008496 DPH2 1802 RNAseq 0.7906 0.0021
SRP064894 DPH2 1802 RNAseq 0.5562 0.0092
SRP133303 DPH2 1802 RNAseq 0.7256 0.0003
SRP159526 DPH2 1802 RNAseq 0.5645 0.1014
SRP193095 DPH2 1802 RNAseq 0.6070 0.0000
SRP219564 DPH2 1802 RNAseq 0.7549 0.0890
TCGA DPH2 1802 RNAseq 0.2053 0.0003

Upregulated datasets: 1; Downregulated datasets: 0.  

 

Survival by DPH2 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of DPH2:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 DPH2 1802 4 3 23
GSE20123 DPH2 1802 4 2 24
GSE43470 DPH2 1802 7 2 34
GSE46452 DPH2 1802 2 1 56
GSE47630 DPH2 1802 9 3 28
GSE54993 DPH2 1802 0 2 68
GSE54994 DPH2 1802 14 2 37
GSE60625 DPH2 1802 0 0 11
GSE74703 DPH2 1802 6 1 29
GSE74704 DPH2 1802 2 0 18
TCGA DPH2 1802 14 16 66

Total number of gains: 62; Total number of losses: 32; Total Number of normals: 394.  

 

Somatic mutations of DPH2:

 

Generating mutation plots.

 

Highly correlated genes for DPH2:

 

Showing top 20/859 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
DPH2RAD54L0.682019706
DPH2TRIP130.678455808
DPH2CTPS10.67443310010
DPH2NACC10.66267303
DPH2CCNF0.662651909
DPH2U2AF10.662341403
DPH2NDC10.661422808
DPH2CDCA80.660483908
DPH2ZNF740.659169706
DPH2METTL10.653062808
DPH2ATXN7L20.652321303
DPH2AP1M10.64542503
DPH2TMEM161A0.644815807
DPH2RNA45S50.643178303
DPH2BRIX10.641824909
DPH2TMEM63B0.638677303
DPH2ALG30.6384871109
DPH2COA70.638168908
DPH2ATAD3A0.63714605
DPH2UBE2C0.635044908

For details and further investigation, click here