| Full name: methyltransferase like 1 | Alias Symbol: TRM8|TRMT8 | ||
| Type: protein-coding gene | Cytoband: 12q14.1 | ||
| Entrez ID: 4234 | HGNC ID: HGNC:7030 | Ensembl Gene: ENSG00000037897 | OMIM ID: 604466 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of METTL1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | METTL1 | 4234 | 204027_s_at | 0.6366 | 0.1404 | |
| GSE20347 | METTL1 | 4234 | 204027_s_at | 0.6142 | 0.0011 | |
| GSE23400 | METTL1 | 4234 | 204027_s_at | 0.4922 | 0.0000 | |
| GSE26886 | METTL1 | 4234 | 204027_s_at | 1.1213 | 0.0000 | |
| GSE29001 | METTL1 | 4234 | 204027_s_at | 0.4144 | 0.0438 | |
| GSE38129 | METTL1 | 4234 | 204027_s_at | 0.8313 | 0.0000 | |
| GSE45670 | METTL1 | 4234 | 204027_s_at | 0.5332 | 0.0002 | |
| GSE53622 | METTL1 | 4234 | 21253 | 0.7044 | 0.0000 | |
| GSE53624 | METTL1 | 4234 | 21253 | 0.8901 | 0.0000 | |
| GSE63941 | METTL1 | 4234 | 204027_s_at | 0.3254 | 0.3604 | |
| GSE77861 | METTL1 | 4234 | 204027_s_at | 0.2180 | 0.2170 | |
| GSE97050 | METTL1 | 4234 | A_33_P3700794 | 0.1470 | 0.8899 | |
| SRP007169 | METTL1 | 4234 | RNAseq | 1.0261 | 0.0198 | |
| SRP008496 | METTL1 | 4234 | RNAseq | 0.7265 | 0.0207 | |
| SRP064894 | METTL1 | 4234 | RNAseq | 0.8902 | 0.0004 | |
| SRP133303 | METTL1 | 4234 | RNAseq | 1.0341 | 0.0000 | |
| SRP159526 | METTL1 | 4234 | RNAseq | 0.9173 | 0.0108 | |
| SRP193095 | METTL1 | 4234 | RNAseq | 0.5903 | 0.0000 | |
| SRP219564 | METTL1 | 4234 | RNAseq | 0.9607 | 0.0118 | |
| TCGA | METTL1 | 4234 | RNAseq | 0.3652 | 0.0000 |
Upregulated datasets: 3; Downregulated datasets: 0.
Survival by METTL1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of METTL1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | METTL1 | 4234 | 7 | 1 | 22 | |
| GSE20123 | METTL1 | 4234 | 7 | 0 | 23 | |
| GSE43470 | METTL1 | 4234 | 2 | 0 | 41 | |
| GSE46452 | METTL1 | 4234 | 8 | 1 | 50 | |
| GSE47630 | METTL1 | 4234 | 10 | 2 | 28 | |
| GSE54993 | METTL1 | 4234 | 0 | 5 | 65 | |
| GSE54994 | METTL1 | 4234 | 4 | 1 | 48 | |
| GSE60625 | METTL1 | 4234 | 0 | 0 | 11 | |
| GSE74703 | METTL1 | 4234 | 2 | 0 | 34 | |
| GSE74704 | METTL1 | 4234 | 5 | 0 | 15 | |
| TCGA | METTL1 | 4234 | 14 | 10 | 72 |
Total number of gains: 59; Total number of losses: 20; Total Number of normals: 409.
Somatic mutations of METTL1:
Generating mutation plots.
Highly correlated genes for METTL1:
Showing top 20/1374 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| METTL1 | CMSS1 | 0.763209 | 5 | 0 | 5 |
| METTL1 | CHTF18 | 0.754674 | 4 | 0 | 4 |
| METTL1 | PRR12 | 0.744624 | 3 | 0 | 3 |
| METTL1 | MTBP | 0.736363 | 4 | 0 | 4 |
| METTL1 | MRPL47 | 0.735156 | 5 | 0 | 5 |
| METTL1 | FBRSL1 | 0.734562 | 4 | 0 | 4 |
| METTL1 | YDJC | 0.716324 | 7 | 0 | 6 |
| METTL1 | RIOK1 | 0.703135 | 5 | 0 | 4 |
| METTL1 | MTFR2 | 0.702644 | 6 | 0 | 6 |
| METTL1 | NACC1 | 0.70062 | 4 | 0 | 3 |
| METTL1 | RCC2 | 0.699559 | 4 | 0 | 3 |
| METTL1 | ZNF628 | 0.69837 | 4 | 0 | 3 |
| METTL1 | CCNF | 0.69628 | 10 | 0 | 10 |
| METTL1 | ZNF469 | 0.695391 | 4 | 0 | 4 |
| METTL1 | DHX37 | 0.694209 | 6 | 0 | 5 |
| METTL1 | HDAC7 | 0.692885 | 3 | 0 | 3 |
| METTL1 | STMN3 | 0.692618 | 3 | 0 | 3 |
| METTL1 | NIFK | 0.690109 | 6 | 0 | 5 |
| METTL1 | G2E3 | 0.689285 | 4 | 0 | 4 |
| METTL1 | SIX4 | 0.689052 | 6 | 0 | 6 |
For details and further investigation, click here
