| Full name: dihydropyrimidinase | Alias Symbol: DHPase | ||
| Type: protein-coding gene | Cytoband: 8q22.3 | ||
| Entrez ID: 1807 | HGNC ID: HGNC:3013 | Ensembl Gene: ENSG00000147647 | OMIM ID: 613326 |
| Drug and gene relationship at DGIdb | |||
Expression of DPYS:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DPYS | 1807 | 206065_s_at | 0.1699 | 0.6714 | |
| GSE20347 | DPYS | 1807 | 206065_s_at | 0.0002 | 0.9976 | |
| GSE23400 | DPYS | 1807 | 206065_s_at | -0.0364 | 0.1410 | |
| GSE26886 | DPYS | 1807 | 206065_s_at | -0.0419 | 0.6555 | |
| GSE29001 | DPYS | 1807 | 206065_s_at | 0.0795 | 0.6295 | |
| GSE38129 | DPYS | 1807 | 206065_s_at | -0.0860 | 0.0901 | |
| GSE45670 | DPYS | 1807 | 206065_s_at | -0.0395 | 0.6841 | |
| GSE53622 | DPYS | 1807 | 145833 | 0.2236 | 0.0138 | |
| GSE53624 | DPYS | 1807 | 145833 | 0.2601 | 0.0230 | |
| GSE63941 | DPYS | 1807 | 206065_s_at | 0.0944 | 0.5419 | |
| GSE77861 | DPYS | 1807 | 206065_s_at | -0.1728 | 0.0924 | |
| TCGA | DPYS | 1807 | RNAseq | 2.6120 | 0.0101 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by DPYS expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DPYS:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DPYS | 1807 | 16 | 0 | 14 | |
| GSE20123 | DPYS | 1807 | 17 | 0 | 13 | |
| GSE43470 | DPYS | 1807 | 22 | 0 | 21 | |
| GSE46452 | DPYS | 1807 | 24 | 0 | 35 | |
| GSE47630 | DPYS | 1807 | 24 | 0 | 16 | |
| GSE54993 | DPYS | 1807 | 0 | 20 | 50 | |
| GSE54994 | DPYS | 1807 | 37 | 1 | 15 | |
| GSE60625 | DPYS | 1807 | 0 | 4 | 7 | |
| GSE74703 | DPYS | 1807 | 19 | 0 | 17 | |
| GSE74704 | DPYS | 1807 | 11 | 0 | 9 | |
| TCGA | DPYS | 1807 | 60 | 1 | 35 |
Total number of gains: 230; Total number of losses: 26; Total Number of normals: 232.
Somatic mutations of DPYS:
Generating mutation plots.
Highly correlated genes for DPYS:
Showing top 20/92 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DPYS | C7orf61 | 0.732444 | 3 | 0 | 3 |
| DPYS | PPP3R2 | 0.719896 | 3 | 0 | 3 |
| DPYS | CD247 | 0.66316 | 4 | 0 | 3 |
| DPYS | RIT2 | 0.663019 | 4 | 0 | 3 |
| DPYS | TTN | 0.662266 | 3 | 0 | 3 |
| DPYS | IL2RG | 0.660718 | 3 | 0 | 3 |
| DPYS | VASH1 | 0.660227 | 3 | 0 | 3 |
| DPYS | SMIM2 | 0.644664 | 3 | 0 | 3 |
| DPYS | CCL27 | 0.639099 | 3 | 0 | 3 |
| DPYS | KCNF1 | 0.633551 | 3 | 0 | 3 |
| DPYS | FGF21 | 0.628886 | 3 | 0 | 3 |
| DPYS | TBX21 | 0.627934 | 3 | 0 | 3 |
| DPYS | SIRPD | 0.621642 | 3 | 0 | 3 |
| DPYS | QPCTL | 0.618739 | 3 | 0 | 3 |
| DPYS | PPM1E | 0.617804 | 4 | 0 | 3 |
| DPYS | SH2D1A | 0.606268 | 5 | 0 | 3 |
| DPYS | GPT | 0.602922 | 4 | 0 | 3 |
| DPYS | HLA-DOB | 0.601235 | 3 | 0 | 3 |
| DPYS | IFNA14 | 0.598152 | 3 | 0 | 3 |
| DPYS | DNMT3L | 0.595165 | 4 | 0 | 3 |
For details and further investigation, click here
