| Full name: desmoglein 3 | Alias Symbol: CDHF6 | ||
| Type: protein-coding gene | Cytoband: 18q12.1 | ||
| Entrez ID: 1830 | HGNC ID: HGNC:3050 | Ensembl Gene: ENSG00000134757 | OMIM ID: 169615 |
| Drug and gene relationship at DGIdb | |||
Expression of DSG3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DSG3 | 1830 | 235075_at | -0.5909 | 0.5332 | |
| GSE20347 | DSG3 | 1830 | 205595_at | -1.4543 | 0.0001 | |
| GSE23400 | DSG3 | 1830 | 205595_at | -1.1620 | 0.0000 | |
| GSE26886 | DSG3 | 1830 | 235075_at | -1.8925 | 0.0000 | |
| GSE29001 | DSG3 | 1830 | 205595_at | -1.5416 | 0.0040 | |
| GSE38129 | DSG3 | 1830 | 205595_at | -0.4493 | 0.5910 | |
| GSE45670 | DSG3 | 1830 | 235075_at | -0.0019 | 0.9946 | |
| GSE53622 | DSG3 | 1830 | 22762 | -1.2394 | 0.0003 | |
| GSE53624 | DSG3 | 1830 | 22762 | -1.6045 | 0.0000 | |
| GSE63941 | DSG3 | 1830 | 205595_at | 4.9010 | 0.0031 | |
| GSE77861 | DSG3 | 1830 | 235075_at | -0.4073 | 0.4312 | |
| GSE97050 | DSG3 | 1830 | A_33_P3348747 | 0.6579 | 0.6357 | |
| SRP007169 | DSG3 | 1830 | RNAseq | -1.2890 | 0.0192 | |
| SRP008496 | DSG3 | 1830 | RNAseq | -1.6371 | 0.0001 | |
| SRP064894 | DSG3 | 1830 | RNAseq | -1.8036 | 0.0002 | |
| SRP133303 | DSG3 | 1830 | RNAseq | -0.9724 | 0.0164 | |
| SRP159526 | DSG3 | 1830 | RNAseq | -1.8703 | 0.0168 | |
| SRP193095 | DSG3 | 1830 | RNAseq | -1.1868 | 0.0188 | |
| SRP219564 | DSG3 | 1830 | RNAseq | -2.3518 | 0.0756 | |
| TCGA | DSG3 | 1830 | RNAseq | 1.2613 | 0.0000 |
Upregulated datasets: 2; Downregulated datasets: 11.
Survival by DSG3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DSG3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DSG3 | 1830 | 2 | 6 | 22 | |
| GSE20123 | DSG3 | 1830 | 2 | 6 | 22 | |
| GSE43470 | DSG3 | 1830 | 0 | 2 | 41 | |
| GSE46452 | DSG3 | 1830 | 1 | 25 | 33 | |
| GSE47630 | DSG3 | 1830 | 5 | 20 | 15 | |
| GSE54993 | DSG3 | 1830 | 7 | 1 | 62 | |
| GSE54994 | DSG3 | 1830 | 2 | 16 | 35 | |
| GSE60625 | DSG3 | 1830 | 0 | 4 | 7 | |
| GSE74703 | DSG3 | 1830 | 0 | 2 | 34 | |
| GSE74704 | DSG3 | 1830 | 0 | 5 | 15 | |
| TCGA | DSG3 | 1830 | 14 | 36 | 46 |
Total number of gains: 33; Total number of losses: 123; Total Number of normals: 332.
Somatic mutations of DSG3:
Generating mutation plots.
Highly correlated genes for DSG3:
Showing top 20/1115 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DSG3 | DSC2 | 0.836884 | 13 | 0 | 13 |
| DSG3 | KRT6C | 0.802979 | 4 | 0 | 4 |
| DSG3 | S100A16 | 0.802667 | 8 | 0 | 8 |
| DSG3 | ANXA1 | 0.799013 | 11 | 0 | 11 |
| DSG3 | SERPINB5 | 0.798737 | 13 | 0 | 12 |
| DSG3 | DSP | 0.787145 | 13 | 0 | 13 |
| DSG3 | MPZL2 | 0.786546 | 13 | 0 | 12 |
| DSG3 | LYPD3 | 0.782543 | 12 | 0 | 12 |
| DSG3 | CERS3 | 0.775692 | 7 | 0 | 7 |
| DSG3 | NIPAL1 | 0.774546 | 3 | 0 | 3 |
| DSG3 | ARAP2 | 0.773113 | 4 | 0 | 4 |
| DSG3 | SERPINB1 | 0.762264 | 12 | 0 | 12 |
| DSG3 | KLF5 | 0.759436 | 12 | 0 | 12 |
| DSG3 | PERP | 0.757732 | 12 | 0 | 12 |
| DSG3 | CTNND1 | 0.756219 | 3 | 0 | 3 |
| DSG3 | SERPINB13 | 0.752425 | 13 | 0 | 12 |
| DSG3 | ZNF750 | 0.751133 | 13 | 0 | 12 |
| DSG3 | MALL | 0.75109 | 12 | 0 | 11 |
| DSG3 | LIPH | 0.749975 | 5 | 0 | 5 |
| DSG3 | TPD52L1 | 0.748728 | 10 | 0 | 10 |
For details and further investigation, click here
