| Full name: junction plakoglobin | Alias Symbol: DP3|PDGB|PKGB|DPIII | ||
| Type: protein-coding gene | Cytoband: 17q21.2 | ||
| Entrez ID: 3728 | HGNC ID: HGNC:6207 | Ensembl Gene: ENSG00000173801 | OMIM ID: 173325 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
JUP involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa05200 | Pathways in cancer | |
| hsa05221 | Acute myeloid leukemia |
Expression of JUP:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | JUP | 3728 | 201015_s_at | -0.1142 | 0.8880 | |
| GSE20347 | JUP | 3728 | 201015_s_at | -0.6525 | 0.0002 | |
| GSE23400 | JUP | 3728 | 201015_s_at | -0.1875 | 0.1432 | |
| GSE26886 | JUP | 3728 | 201015_s_at | -1.1427 | 0.0032 | |
| GSE29001 | JUP | 3728 | 201015_s_at | -0.8486 | 0.0956 | |
| GSE38129 | JUP | 3728 | 201015_s_at | 0.1701 | 0.7098 | |
| GSE45670 | JUP | 3728 | 201015_s_at | 0.1281 | 0.4125 | |
| GSE53622 | JUP | 3728 | 63411 | -0.4025 | 0.0796 | |
| GSE53624 | JUP | 3728 | 63411 | -0.6801 | 0.0000 | |
| GSE63941 | JUP | 3728 | 201015_s_at | 2.7296 | 0.0004 | |
| GSE77861 | JUP | 3728 | 201015_s_at | 0.0352 | 0.9325 | |
| GSE97050 | JUP | 3728 | A_23_P501822 | 0.9180 | 0.4339 | |
| SRP007169 | JUP | 3728 | RNAseq | -1.4786 | 0.0001 | |
| SRP008496 | JUP | 3728 | RNAseq | -1.7353 | 0.0000 | |
| SRP064894 | JUP | 3728 | RNAseq | -0.7810 | 0.0214 | |
| SRP133303 | JUP | 3728 | RNAseq | -0.7962 | 0.0096 | |
| SRP159526 | JUP | 3728 | RNAseq | -0.9402 | 0.0755 | |
| SRP193095 | JUP | 3728 | RNAseq | -0.6658 | 0.0029 | |
| SRP219564 | JUP | 3728 | RNAseq | -0.9489 | 0.2910 | |
| TCGA | JUP | 3728 | RNAseq | 0.4644 | 0.0000 |
Upregulated datasets: 1; Downregulated datasets: 3.
Survival by JUP expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of JUP:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | JUP | 3728 | 6 | 2 | 22 | |
| GSE20123 | JUP | 3728 | 6 | 2 | 22 | |
| GSE43470 | JUP | 3728 | 1 | 2 | 40 | |
| GSE46452 | JUP | 3728 | 34 | 0 | 25 | |
| GSE47630 | JUP | 3728 | 8 | 1 | 31 | |
| GSE54993 | JUP | 3728 | 3 | 4 | 63 | |
| GSE54994 | JUP | 3728 | 8 | 5 | 40 | |
| GSE60625 | JUP | 3728 | 4 | 0 | 7 | |
| GSE74703 | JUP | 3728 | 1 | 1 | 34 | |
| GSE74704 | JUP | 3728 | 4 | 1 | 15 | |
| TCGA | JUP | 3728 | 23 | 7 | 66 |
Total number of gains: 98; Total number of losses: 25; Total Number of normals: 365.
Somatic mutations of JUP:
Generating mutation plots.
Highly correlated genes for JUP:
Showing top 20/987 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| JUP | CKMT1A | 0.792115 | 3 | 0 | 3 |
| JUP | LAD1 | 0.791451 | 13 | 0 | 13 |
| JUP | MPZL2 | 0.77808 | 9 | 0 | 9 |
| JUP | NIPAL1 | 0.77698 | 3 | 0 | 3 |
| JUP | ARAP2 | 0.769658 | 3 | 0 | 3 |
| JUP | E2F2 | 0.762889 | 4 | 0 | 4 |
| JUP | SERPINB5 | 0.74763 | 11 | 0 | 10 |
| JUP | CERS3 | 0.745599 | 6 | 0 | 5 |
| JUP | MREG | 0.736759 | 10 | 0 | 9 |
| JUP | GNA15 | 0.730435 | 12 | 0 | 11 |
| JUP | PKP1 | 0.724353 | 13 | 0 | 12 |
| JUP | DSC3 | 0.721184 | 10 | 0 | 10 |
| JUP | DSP | 0.719373 | 13 | 0 | 12 |
| JUP | S100A11 | 0.717 | 13 | 0 | 11 |
| JUP | DSG3 | 0.714741 | 13 | 0 | 10 |
| JUP | SLC9A3R1 | 0.714216 | 12 | 0 | 11 |
| JUP | ELOVL1 | 0.713843 | 4 | 0 | 3 |
| JUP | MPZL3 | 0.713784 | 7 | 0 | 7 |
| JUP | CTNND1 | 0.713262 | 3 | 0 | 3 |
| JUP | SDC1 | 0.712059 | 12 | 0 | 11 |
For details and further investigation, click here
