| Full name: keratin 5 | Alias Symbol: KRT5A | ||
| Type: protein-coding gene | Cytoband: 12q13.13 | ||
| Entrez ID: 3852 | HGNC ID: HGNC:6442 | Ensembl Gene: ENSG00000186081 | OMIM ID: 148040 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of KRT5:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | KRT5 | 3852 | 201820_at | 0.0403 | 0.8932 | |
| GSE20347 | KRT5 | 3852 | 201820_at | -0.1899 | 0.2284 | |
| GSE23400 | KRT5 | 3852 | 201820_at | 0.1622 | 0.2226 | |
| GSE26886 | KRT5 | 3852 | 201820_at | -0.5863 | 0.0238 | |
| GSE29001 | KRT5 | 3852 | 201820_at | -0.3137 | 0.4828 | |
| GSE38129 | KRT5 | 3852 | 201820_at | 0.9067 | 0.1825 | |
| GSE45670 | KRT5 | 3852 | 201820_at | 0.6606 | 0.0002 | |
| GSE53622 | KRT5 | 3852 | 44972 | -0.2049 | 0.5141 | |
| GSE53624 | KRT5 | 3852 | 44972 | -0.7282 | 0.0000 | |
| GSE63941 | KRT5 | 3852 | 201820_at | 4.7941 | 0.0344 | |
| GSE77861 | KRT5 | 3852 | 201820_at | -0.1171 | 0.6155 | |
| GSE97050 | KRT5 | 3852 | A_23_P218047 | 1.8441 | 0.3023 | |
| SRP007169 | KRT5 | 3852 | RNAseq | -1.0303 | 0.0085 | |
| SRP008496 | KRT5 | 3852 | RNAseq | -0.7764 | 0.0191 | |
| SRP064894 | KRT5 | 3852 | RNAseq | -0.4505 | 0.3343 | |
| SRP133303 | KRT5 | 3852 | RNAseq | -0.4506 | 0.1729 | |
| SRP159526 | KRT5 | 3852 | RNAseq | -0.4454 | 0.3389 | |
| SRP219564 | KRT5 | 3852 | RNAseq | -0.5125 | 0.6834 | |
| TCGA | KRT5 | 3852 | RNAseq | 1.2968 | 0.0000 |
Upregulated datasets: 2; Downregulated datasets: 1.
Survival by KRT5 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of KRT5:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | KRT5 | 3852 | 8 | 1 | 21 | |
| GSE20123 | KRT5 | 3852 | 8 | 1 | 21 | |
| GSE43470 | KRT5 | 3852 | 3 | 0 | 40 | |
| GSE46452 | KRT5 | 3852 | 7 | 1 | 51 | |
| GSE47630 | KRT5 | 3852 | 10 | 2 | 28 | |
| GSE54993 | KRT5 | 3852 | 0 | 5 | 65 | |
| GSE54994 | KRT5 | 3852 | 5 | 1 | 47 | |
| GSE60625 | KRT5 | 3852 | 0 | 0 | 11 | |
| GSE74703 | KRT5 | 3852 | 3 | 0 | 33 | |
| GSE74704 | KRT5 | 3852 | 5 | 1 | 14 | |
| TCGA | KRT5 | 3852 | 13 | 11 | 72 |
Total number of gains: 62; Total number of losses: 23; Total Number of normals: 403.
Somatic mutations of KRT5:
Generating mutation plots.
Highly correlated genes for KRT5:
Showing top 20/380 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| KRT5 | KRT6C | 0.844284 | 4 | 0 | 4 |
| KRT5 | ULBP2 | 0.790593 | 4 | 0 | 4 |
| KRT5 | KRT83 | 0.757451 | 3 | 0 | 3 |
| KRT5 | KRT6B | 0.745566 | 9 | 0 | 9 |
| KRT5 | KRT6A | 0.72533 | 12 | 0 | 10 |
| KRT5 | KRT14 | 0.704521 | 10 | 0 | 9 |
| KRT5 | IFI27L1 | 0.703752 | 3 | 0 | 3 |
| KRT5 | RNASE7 | 0.695507 | 3 | 0 | 3 |
| KRT5 | DSC3 | 0.690987 | 11 | 0 | 9 |
| KRT5 | S100A2 | 0.675625 | 10 | 0 | 8 |
| KRT5 | ARAP2 | 0.673057 | 3 | 0 | 3 |
| KRT5 | DSG3 | 0.672178 | 11 | 0 | 9 |
| KRT5 | DSP | 0.668776 | 12 | 0 | 10 |
| KRT5 | PERP | 0.667977 | 10 | 0 | 8 |
| KRT5 | PKP1 | 0.665676 | 13 | 0 | 10 |
| KRT5 | SERPINB5 | 0.663941 | 10 | 0 | 8 |
| KRT5 | TRIM29 | 0.654689 | 12 | 0 | 9 |
| KRT5 | TMPRSS4 | 0.647802 | 5 | 0 | 4 |
| KRT5 | TSEN54 | 0.64746 | 3 | 0 | 3 |
| KRT5 | FGFBP1 | 0.645901 | 7 | 0 | 5 |
For details and further investigation, click here
