| Full name: dihydrouridine synthase 2 | Alias Symbol: FLJ20399|SMM1 | ||
| Type: protein-coding gene | Cytoband: 16q22.1 | ||
| Entrez ID: 54920 | HGNC ID: HGNC:26014 | Ensembl Gene: ENSG00000167264 | OMIM ID: 609707 |
| Drug and gene relationship at DGIdb | |||
Expression of DUS2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DUS2 | 54920 | 219486_at | 0.3126 | 0.3946 | |
| GSE20347 | DUS2 | 54920 | 219486_at | 0.1603 | 0.0910 | |
| GSE23400 | DUS2 | 54920 | 219486_at | 0.0204 | 0.6108 | |
| GSE26886 | DUS2 | 54920 | 219486_at | 0.0442 | 0.8101 | |
| GSE29001 | DUS2 | 54920 | 219486_at | 0.1608 | 0.4482 | |
| GSE38129 | DUS2 | 54920 | 219486_at | 0.1463 | 0.1148 | |
| GSE45670 | DUS2 | 54920 | 219486_at | 0.3050 | 0.0029 | |
| GSE53622 | DUS2 | 54920 | 3542 | 0.4733 | 0.0000 | |
| GSE53624 | DUS2 | 54920 | 3542 | 0.2946 | 0.0003 | |
| GSE63941 | DUS2 | 54920 | 219486_at | 0.9638 | 0.0006 | |
| GSE77861 | DUS2 | 54920 | 219486_at | 0.1261 | 0.3176 | |
| SRP007169 | DUS2 | 54920 | RNAseq | 0.0665 | 0.8703 | |
| SRP008496 | DUS2 | 54920 | RNAseq | -0.0670 | 0.8241 | |
| SRP064894 | DUS2 | 54920 | RNAseq | 0.4876 | 0.0077 | |
| SRP133303 | DUS2 | 54920 | RNAseq | 0.2557 | 0.2370 | |
| SRP159526 | DUS2 | 54920 | RNAseq | -0.0393 | 0.8999 | |
| SRP193095 | DUS2 | 54920 | RNAseq | 0.2266 | 0.0856 | |
| SRP219564 | DUS2 | 54920 | RNAseq | 0.0321 | 0.9208 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by DUS2 expression:
 |  |
| GSE53622 | GSE53624 |
Note: Click image to view full size file.
Copy number change of DUS2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DUS2 | 54920 | 9 | 2 | 19 | |
| GSE20123 | DUS2 | 54920 | 9 | 2 | 19 | |
| GSE43470 | DUS2 | 54920 | 1 | 9 | 33 | |
| GSE46452 | DUS2 | 54920 | 38 | 1 | 20 | |
| GSE47630 | DUS2 | 54920 | 11 | 8 | 21 | |
| GSE54993 | DUS2 | 54920 | 2 | 4 | 64 | |
| GSE54994 | DUS2 | 54920 | 8 | 10 | 35 | |
| GSE60625 | DUS2 | 54920 | 4 | 0 | 7 | |
| GSE74703 | DUS2 | 54920 | 1 | 6 | 29 | |
| GSE74704 | DUS2 | 54920 | 5 | 1 | 14 |
Total number of gains: 88; Total number of losses: 43; Total Number of normals: 261.
Somatic mutations of DUS2:
Generating mutation plots.
Highly correlated genes for DUS2:
Showing top 20/355 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DUS2 | SLAMF9 | 0.742032 | 3 | 0 | 3 |
| DUS2 | TCEANC2 | 0.728472 | 3 | 0 | 3 |
| DUS2 | DRAP1 | 0.70587 | 3 | 0 | 3 |
| DUS2 | SNAPC2 | 0.657459 | 3 | 0 | 3 |
| DUS2 | NOB1 | 0.653762 | 4 | 0 | 3 |
| DUS2 | MAF1 | 0.646557 | 3 | 0 | 3 |
| DUS2 | MTFP1 | 0.646253 | 4 | 0 | 3 |
| DUS2 | ICAM1 | 0.643907 | 3 | 0 | 3 |
| DUS2 | NAA10 | 0.641482 | 4 | 0 | 3 |
| DUS2 | TANGO6 | 0.635439 | 5 | 0 | 3 |
| DUS2 | TERF2 | 0.632334 | 4 | 0 | 3 |
| DUS2 | EME1 | 0.631639 | 4 | 0 | 3 |
| DUS2 | DHX38 | 0.626657 | 8 | 0 | 5 |
| DUS2 | COX4I1 | 0.625488 | 3 | 0 | 3 |
| DUS2 | DDX28 | 0.623367 | 9 | 0 | 8 |
| DUS2 | ERI3 | 0.621278 | 4 | 0 | 3 |
| DUS2 | NTMT1 | 0.620152 | 5 | 0 | 5 |
| DUS2 | MMP15 | 0.61863 | 6 | 0 | 4 |
| DUS2 | EXTL3 | 0.61804 | 7 | 0 | 5 |
| DUS2 | DDX19A | 0.61689 | 6 | 0 | 4 |
For details and further investigation, click here
