| Full name: dual specificity tyrosine phosphorylation regulated kinase 1A | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 21q22.13 | ||
| Entrez ID: 1859 | HGNC ID: HGNC:3091 | Ensembl Gene: ENSG00000157540 | OMIM ID: 600855 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of DYRK1A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DYRK1A | 1859 | 209033_s_at | -0.1920 | 0.7133 | |
| GSE20347 | DYRK1A | 1859 | 209033_s_at | -0.2888 | 0.0655 | |
| GSE23400 | DYRK1A | 1859 | 209033_s_at | 0.0113 | 0.9010 | |
| GSE26886 | DYRK1A | 1859 | 209033_s_at | -0.4206 | 0.0673 | |
| GSE29001 | DYRK1A | 1859 | 209033_s_at | 0.0375 | 0.9127 | |
| GSE38129 | DYRK1A | 1859 | 209033_s_at | -0.2607 | 0.0116 | |
| GSE45670 | DYRK1A | 1859 | 209033_s_at | -0.3115 | 0.0069 | |
| GSE53622 | DYRK1A | 1859 | 97034 | -0.1985 | 0.0005 | |
| GSE53624 | DYRK1A | 1859 | 97034 | -0.2943 | 0.0000 | |
| GSE63941 | DYRK1A | 1859 | 209033_s_at | -0.5191 | 0.1230 | |
| GSE77861 | DYRK1A | 1859 | 209033_s_at | -0.3283 | 0.2669 | |
| GSE97050 | DYRK1A | 1859 | A_33_P3322050 | -0.1162 | 0.5858 | |
| SRP007169 | DYRK1A | 1859 | RNAseq | -0.1218 | 0.7426 | |
| SRP008496 | DYRK1A | 1859 | RNAseq | 0.2381 | 0.3436 | |
| SRP064894 | DYRK1A | 1859 | RNAseq | -0.1411 | 0.4424 | |
| SRP133303 | DYRK1A | 1859 | RNAseq | -0.2999 | 0.0147 | |
| SRP159526 | DYRK1A | 1859 | RNAseq | -0.3687 | 0.0278 | |
| SRP193095 | DYRK1A | 1859 | RNAseq | -0.2206 | 0.0009 | |
| SRP219564 | DYRK1A | 1859 | RNAseq | -0.3716 | 0.1945 | |
| TCGA | DYRK1A | 1859 | RNAseq | -0.0970 | 0.0304 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by DYRK1A expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DYRK1A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DYRK1A | 1859 | 2 | 8 | 20 | |
| GSE20123 | DYRK1A | 1859 | 2 | 9 | 19 | |
| GSE43470 | DYRK1A | 1859 | 1 | 10 | 32 | |
| GSE46452 | DYRK1A | 1859 | 1 | 21 | 37 | |
| GSE47630 | DYRK1A | 1859 | 6 | 17 | 17 | |
| GSE54993 | DYRK1A | 1859 | 8 | 1 | 61 | |
| GSE54994 | DYRK1A | 1859 | 2 | 9 | 42 | |
| GSE60625 | DYRK1A | 1859 | 0 | 0 | 11 | |
| GSE74703 | DYRK1A | 1859 | 1 | 7 | 28 | |
| GSE74704 | DYRK1A | 1859 | 1 | 6 | 13 | |
| TCGA | DYRK1A | 1859 | 8 | 40 | 48 |
Total number of gains: 32; Total number of losses: 128; Total Number of normals: 328.
Somatic mutations of DYRK1A:
Generating mutation plots.
Highly correlated genes for DYRK1A:
Showing top 20/165 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DYRK1A | MTFR1L | 0.663182 | 5 | 0 | 4 |
| DYRK1A | IFT57 | 0.657978 | 3 | 0 | 3 |
| DYRK1A | ZNF621 | 0.625401 | 4 | 0 | 3 |
| DYRK1A | CUL1 | 0.623024 | 4 | 0 | 3 |
| DYRK1A | SON | 0.620243 | 10 | 0 | 9 |
| DYRK1A | ZC3H6 | 0.619594 | 5 | 0 | 5 |
| DYRK1A | CDK15 | 0.619579 | 5 | 0 | 4 |
| DYRK1A | USP48 | 0.616602 | 4 | 0 | 3 |
| DYRK1A | SPATA6 | 0.611541 | 5 | 0 | 4 |
| DYRK1A | EEF1A1 | 0.609483 | 5 | 0 | 5 |
| DYRK1A | TMEM108 | 0.607756 | 4 | 0 | 3 |
| DYRK1A | SYF2 | 0.606792 | 5 | 0 | 4 |
| DYRK1A | SENP8 | 0.597263 | 3 | 0 | 3 |
| DYRK1A | ZNF10 | 0.594866 | 4 | 0 | 3 |
| DYRK1A | PNRC2 | 0.590867 | 9 | 0 | 7 |
| DYRK1A | FAM228B | 0.589524 | 5 | 0 | 3 |
| DYRK1A | ID4 | 0.587477 | 5 | 0 | 4 |
| DYRK1A | PAXBP1 | 0.587148 | 6 | 0 | 4 |
| DYRK1A | SYNJ1 | 0.587082 | 8 | 0 | 8 |
| DYRK1A | USP16 | 0.586672 | 10 | 0 | 7 |
For details and further investigation, click here
