E2F3

 

Full name: E2F transcription factor 3 Alias Symbol: 
Type: protein-coding gene Cytoband: 6p22.3
Entrez ID: 1871 HGNC ID: HGNC:3115 Ensembl Gene: ENSG00000112242 OMIM ID: 600427
Drug and gene relationship at DGIdb
Screen Evidence:

 

E2F3 involved pathways:

KEGG pathway Description View
hsa04110Cell cycle
hsa05161Hepatitis B
hsa05166HTLV-I infection
hsa05200Pathways in cancer
hsa05212Pancreatic cancer
hsa05214Glioma
hsa05215Prostate cancer
hsa05218Melanoma
hsa05219Bladder cancer
hsa05220Chronic myeloid leukemia
hsa05222Small cell lung cancer
hsa05223Non-small cell lung cancer

 

Expression of E2F3:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 E2F3 1871 203693_s_at 1.5455 0.0684
GSE20347 E2F3 1871 203693_s_at 1.2808 0.0000
GSE23400 E2F3 1871 203692_s_at 0.1925 0.0000
GSE26886 E2F3 1871 203693_s_at 0.8523 0.0059
GSE29001 E2F3 1871 203693_s_at 1.1907 0.0001
GSE38129 E2F3 1871 203693_s_at 1.4764 0.0000
GSE45670 E2F3 1871 203693_s_at 0.8336 0.0001
GSE53622 E2F3 1871 20494 0.5495 0.0000
GSE53624 E2F3 1871 20494 0.8040 0.0000
GSE63941 E2F3 1871 203693_s_at -1.0643 0.0328
GSE77861 E2F3 1871 203693_s_at 0.7417 0.0032
GSE97050 E2F3 1871 A_23_P385034 0.6158 0.1729
SRP007169 E2F3 1871 RNAseq 1.9644 0.0000
SRP008496 E2F3 1871 RNAseq 1.8003 0.0000
SRP064894 E2F3 1871 RNAseq 0.9719 0.0001
SRP133303 E2F3 1871 RNAseq 0.8522 0.0000
SRP159526 E2F3 1871 RNAseq 1.0926 0.0076
SRP193095 E2F3 1871 RNAseq 0.6632 0.0000
SRP219564 E2F3 1871 RNAseq 0.6725 0.0865
TCGA E2F3 1871 RNAseq 0.4036 0.0000

Upregulated datasets: 6; Downregulated datasets: 1.  

 

Survival by E2F3 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of E2F3:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 E2F3 1871 4 4 22
GSE20123 E2F3 1871 4 4 22
GSE43470 E2F3 1871 10 0 33
GSE46452 E2F3 1871 3 9 47
GSE47630 E2F3 1871 10 4 26
GSE54993 E2F3 1871 1 1 68
GSE54994 E2F3 1871 12 3 38
GSE60625 E2F3 1871 0 1 10
GSE74703 E2F3 1871 9 0 27
GSE74704 E2F3 1871 1 1 18
TCGA E2F3 1871 18 23 55

Total number of gains: 72; Total number of losses: 50; Total Number of normals: 366.  

 

Somatic mutations of E2F3:

 

Generating mutation plots.

 

Highly correlated genes for E2F3:

 

Showing top 20/1396 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
E2F3PRDM150.786406303
E2F3NOP580.747465707
E2F3TAP20.744012303
E2F3WDR810.74104404
E2F3PDCD2L0.7333504
E2F3PLEKHM20.729652303
E2F3DDB10.72419303
E2F3TMTC40.7238403
E2F3CHD1L0.723363909
E2F3DNMT10.72129611010
E2F3TCF30.72057111011
E2F3ZFP410.717825303
E2F3RICTOR0.716665303
E2F3RNF2170.710735504
E2F3DCAF130.710529909
E2F3ANAPC10.70863303
E2F3PHF230.707625303
E2F3ALKBH60.70604505
E2F3KBTBD60.705345505
E2F3DNAJC130.70125303

For details and further investigation, click here