BID

 

Full name: BH3 interacting domain death agonist Alias Symbol: 
Type: protein-coding gene Cytoband: 22q11.21
Entrez ID: 637 HGNC ID: HGNC:1050 Ensembl Gene: ENSG00000015475 OMIM ID: 601997
Drug and gene relationship at DGIdb

 

BID involved pathways:

KEGG pathway Description View
hsa04071Sphingolipid signaling pathway
hsa04115p53 signaling pathway
hsa04210Apoptosis
hsa04650Natural killer cell mediated cytotoxicity
hsa04932Non-alcoholic fatty liver disease (NAFLD)
hsa05010Alzheimer's disease
hsa05152Tuberculosis
hsa05200Pathways in cancer

 

Expression of BID:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 BID 637 227143_s_at 1.3512 0.0086
GSE20347 BID 637 211725_s_at 2.0896 0.0000
GSE23400 BID 637 211725_s_at 1.0677 0.0000
GSE26886 BID 637 227143_s_at 1.8821 0.0000
GSE29001 BID 637 204493_at 1.3157 0.0056
GSE38129 BID 637 211725_s_at 2.1782 0.0000
GSE45670 BID 637 227143_s_at 0.9622 0.0012
GSE53622 BID 637 5771 1.5590 0.0000
GSE53624 BID 637 5771 1.8913 0.0000
GSE63941 BID 637 211725_s_at 0.5946 0.2898
GSE77861 BID 637 227143_s_at 1.1698 0.0041
GSE97050 BID 637 A_24_P187948 0.9823 0.2237
SRP007169 BID 637 RNAseq 2.8349 0.0001
SRP008496 BID 637 RNAseq 2.7886 0.0000
SRP064894 BID 637 RNAseq 1.6357 0.0000
SRP133303 BID 637 RNAseq 1.4822 0.0000
SRP159526 BID 637 RNAseq 1.4304 0.0002
SRP193095 BID 637 RNAseq 1.0969 0.0000
SRP219564 BID 637 RNAseq 0.9668 0.0045
TCGA BID 637 RNAseq 0.4836 0.0000

Upregulated datasets: 15; Downregulated datasets: 0.  

 

Survival by BID expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of BID:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 BID 637 4 7 19
GSE20123 BID 637 4 7 19
GSE43470 BID 637 5 7 31
GSE46452 BID 637 32 2 25
GSE47630 BID 637 8 5 27
GSE54993 BID 637 3 6 61
GSE54994 BID 637 12 7 34
GSE60625 BID 637 5 0 6
GSE74703 BID 637 5 5 26
GSE74704 BID 637 2 4 14
TCGA BID 637 24 17 55

Total number of gains: 104; Total number of losses: 67; Total Number of normals: 317.  

 

Somatic mutations of BID:

 

Generating mutation plots.

 

Highly correlated genes for BID:

 

Showing top 20/1966 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
BIDCKS1B0.80908611011
BIDECT20.80048411011
BIDRFC40.797811011
BIDTMEM184B0.785991909
BIDSNX100.77928111011
BIDNUDT10.77540311011
BIDE2F60.77370110010
BIDC1orf1310.773329606
BIDLRRC8D0.7690611011
BIDWDR660.768017707
BIDMCM20.76126811011
BIDFOXM10.76114411011
BIDTMEM1380.760192605
BIDLAPTM4B0.75980710010
BIDRANBP10.75940112012
BIDSDCCAG80.759354303
BIDU2SURP0.759309808
BIDCBX30.75790212011
BIDPOLR2H0.75685510010
BIDMMP10.75528311011

For details and further investigation, click here