| Full name: enhancer of mRNA decapping 3 | Alias Symbol: FLJ21128|hYjeF_N2-15q23|YJEFN2|LSM16 | ||
| Type: protein-coding gene | Cytoband: 15q24.1 | ||
| Entrez ID: 80153 | HGNC ID: HGNC:26114 | Ensembl Gene: ENSG00000179151 | OMIM ID: 609842 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of EDC3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | EDC3 | 80153 | 226042_at | 0.3688 | 0.2333 | |
| GSE20347 | EDC3 | 80153 | 219207_at | 0.0948 | 0.5979 | |
| GSE23400 | EDC3 | 80153 | 219207_at | -0.0071 | 0.8999 | |
| GSE26886 | EDC3 | 80153 | 226042_at | -0.0824 | 0.4917 | |
| GSE29001 | EDC3 | 80153 | 219207_at | 0.0550 | 0.8759 | |
| GSE38129 | EDC3 | 80153 | 219207_at | 0.2787 | 0.0306 | |
| GSE45670 | EDC3 | 80153 | 226042_at | 0.3121 | 0.0021 | |
| GSE53622 | EDC3 | 80153 | 66495 | 0.2293 | 0.0080 | |
| GSE53624 | EDC3 | 80153 | 66495 | 0.3975 | 0.0000 | |
| GSE63941 | EDC3 | 80153 | 219207_at | 1.6844 | 0.0041 | |
| GSE77861 | EDC3 | 80153 | 226042_at | 0.1166 | 0.3088 | |
| GSE97050 | EDC3 | 80153 | A_24_P338992 | 0.0115 | 0.9694 | |
| SRP007169 | EDC3 | 80153 | RNAseq | -0.4278 | 0.3034 | |
| SRP008496 | EDC3 | 80153 | RNAseq | -0.2709 | 0.3556 | |
| SRP064894 | EDC3 | 80153 | RNAseq | 0.2121 | 0.0810 | |
| SRP133303 | EDC3 | 80153 | RNAseq | 0.1244 | 0.4018 | |
| SRP159526 | EDC3 | 80153 | RNAseq | 0.1143 | 0.5089 | |
| SRP193095 | EDC3 | 80153 | RNAseq | 0.1928 | 0.0504 | |
| SRP219564 | EDC3 | 80153 | RNAseq | 0.2121 | 0.3568 | |
| TCGA | EDC3 | 80153 | RNAseq | 0.0647 | 0.1989 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by EDC3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of EDC3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | EDC3 | 80153 | 8 | 1 | 21 | |
| GSE20123 | EDC3 | 80153 | 8 | 1 | 21 | |
| GSE43470 | EDC3 | 80153 | 4 | 6 | 33 | |
| GSE46452 | EDC3 | 80153 | 3 | 7 | 49 | |
| GSE47630 | EDC3 | 80153 | 8 | 10 | 22 | |
| GSE54993 | EDC3 | 80153 | 5 | 6 | 59 | |
| GSE54994 | EDC3 | 80153 | 5 | 7 | 41 | |
| GSE60625 | EDC3 | 80153 | 4 | 0 | 7 | |
| GSE74703 | EDC3 | 80153 | 4 | 3 | 29 | |
| GSE74704 | EDC3 | 80153 | 4 | 1 | 15 | |
| TCGA | EDC3 | 80153 | 14 | 15 | 67 |
Total number of gains: 67; Total number of losses: 57; Total Number of normals: 364.
Somatic mutations of EDC3:
Generating mutation plots.
Highly correlated genes for EDC3:
Showing top 20/153 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| EDC3 | ZNF620 | 0.756843 | 3 | 0 | 3 |
| EDC3 | LRFN4 | 0.721097 | 3 | 0 | 3 |
| EDC3 | PPIP5K1 | 0.685237 | 3 | 0 | 3 |
| EDC3 | POLE4 | 0.682879 | 5 | 0 | 3 |
| EDC3 | MIIP | 0.675576 | 3 | 0 | 3 |
| EDC3 | TBC1D7 | 0.670743 | 4 | 0 | 3 |
| EDC3 | APTX | 0.648864 | 4 | 0 | 3 |
| EDC3 | BCL2L12 | 0.643801 | 5 | 0 | 4 |
| EDC3 | NOB1 | 0.640633 | 3 | 0 | 3 |
| EDC3 | POC1A | 0.636996 | 6 | 0 | 4 |
| EDC3 | BAZ2A | 0.626749 | 4 | 0 | 3 |
| EDC3 | ACTR3B | 0.618231 | 5 | 0 | 4 |
| EDC3 | KNSTRN | 0.608663 | 5 | 0 | 4 |
| EDC3 | NUP98 | 0.59896 | 5 | 0 | 3 |
| EDC3 | SF3A3 | 0.598826 | 4 | 0 | 3 |
| EDC3 | PRPF19 | 0.598074 | 7 | 0 | 4 |
| EDC3 | GNB1L | 0.597687 | 6 | 0 | 4 |
| EDC3 | AP1M1 | 0.597619 | 4 | 0 | 3 |
| EDC3 | CDK2 | 0.596943 | 5 | 0 | 3 |
| EDC3 | ZBTB6 | 0.594643 | 6 | 0 | 5 |
For details and further investigation, click here
