| Full name: ribonuclease K | Alias Symbol: MGC71993 | ||
| Type: protein-coding gene | Cytoband: 17p13.1 | ||
| Entrez ID: 440400 | HGNC ID: HGNC:33911 | Ensembl Gene: ENSG00000219200 | OMIM ID: 617098 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of RNASEK:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE53622 | RNASEK | 440400 | 33106 | -0.4111 | 0.0000 | |
| GSE53624 | RNASEK | 440400 | 33106 | -0.2056 | 0.0008 | |
| GSE97050 | RNASEK | 440400 | A_33_P3382351 | 0.0312 | 0.9157 | |
| SRP007169 | RNASEK | 440400 | RNAseq | -0.7644 | 0.0575 | |
| SRP008496 | RNASEK | 440400 | RNAseq | -0.7022 | 0.0056 | |
| SRP064894 | RNASEK | 440400 | RNAseq | 0.2318 | 0.4846 | |
| SRP133303 | RNASEK | 440400 | RNAseq | -0.1645 | 0.2280 | |
| SRP159526 | RNASEK | 440400 | RNAseq | -0.2944 | 0.1372 | |
| SRP193095 | RNASEK | 440400 | RNAseq | -0.2912 | 0.0445 | |
| SRP219564 | RNASEK | 440400 | RNAseq | 0.1160 | 0.6373 | |
| TCGA | RNASEK | 440400 | RNAseq | -0.0061 | 0.9044 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by RNASEK expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of RNASEK:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | RNASEK | 440400 | 4 | 2 | 24 | |
| GSE20123 | RNASEK | 440400 | 4 | 3 | 23 | |
| GSE43470 | RNASEK | 440400 | 1 | 4 | 38 | |
| GSE46452 | RNASEK | 440400 | 34 | 1 | 24 | |
| GSE47630 | RNASEK | 440400 | 7 | 1 | 32 | |
| GSE54993 | RNASEK | 440400 | 4 | 3 | 63 | |
| GSE54994 | RNASEK | 440400 | 5 | 8 | 40 | |
| GSE60625 | RNASEK | 440400 | 4 | 0 | 7 | |
| GSE74703 | RNASEK | 440400 | 1 | 2 | 33 | |
| GSE74704 | RNASEK | 440400 | 2 | 1 | 17 | |
| TCGA | RNASEK | 440400 | 18 | 20 | 58 |
Total number of gains: 84; Total number of losses: 45; Total Number of normals: 359.
Somatic mutations of RNASEK:
Generating mutation plots.
Highly correlated genes for RNASEK:
Showing top 20/56 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| RNASEK | CRADD | 0.73643 | 3 | 0 | 3 |
| RNASEK | TNIP1 | 0.711027 | 3 | 0 | 3 |
| RNASEK | TMEM120A | 0.704955 | 3 | 0 | 3 |
| RNASEK | PHF23 | 0.701664 | 3 | 0 | 3 |
| RNASEK | NME6 | 0.68636 | 3 | 0 | 3 |
| RNASEK | APEH | 0.685984 | 3 | 0 | 3 |
| RNASEK | KLHL18 | 0.685849 | 3 | 0 | 3 |
| RNASEK | EDEM1 | 0.685633 | 3 | 0 | 3 |
| RNASEK | TMEM19 | 0.684868 | 3 | 0 | 3 |
| RNASEK | IK | 0.683423 | 3 | 0 | 3 |
| RNASEK | FLII | 0.673796 | 4 | 0 | 4 |
| RNASEK | ATP6V0D1 | 0.673036 | 4 | 0 | 3 |
| RNASEK | MTF1 | 0.668202 | 3 | 0 | 3 |
| RNASEK | GPR108 | 0.666403 | 4 | 0 | 3 |
| RNASEK | SIAE | 0.661188 | 3 | 0 | 3 |
| RNASEK | UNK | 0.658312 | 3 | 0 | 3 |
| RNASEK | ARHGAP17 | 0.657415 | 3 | 0 | 3 |
| RNASEK | PRMT2 | 0.657027 | 3 | 0 | 3 |
| RNASEK | INPP1 | 0.65265 | 3 | 0 | 3 |
| RNASEK | ITCH | 0.65224 | 3 | 0 | 3 |
For details and further investigation, click here
